Abstract:<p>The loss of pancreatic β-cell identity emerges as an important feature of type 2 diabetes development, but the molecular mechanisms are still elusive. Here, we explore the cell-autonomous role of the cell cycle regulator and transcription factor E2F1 in the maintenance of β-cell identity, insulin secretion and glucose homeostasis. We show that the β-cell-specific loss of <em>E2f1 </em>function in mice triggers glucose intolerance associated with defective insulin secretion, an altered endo… Show more
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