<strong>Two QSAR Paradigms- Congenericity Principle versus Diversity Begets Diversity Principle- analyzed using computed mathematical chemodescriptors of homogeneous and diverse sets of chemical mutagens</strong>
Abstract:Abstract:The age old paradigm of quantitative structure-activity relationship (QSAR) is the congenericity principle which states that similar structures usually have similar properties. But these days a lot of large and structurally diverse data sets of chemicals with the same experimental data (dependent variable) are available. Starting with the same classes of descriptors we extracted the two subsets of the most significant predictors for the formulation of QSARs for two sets of chemicals: A homogeneous set… Show more
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