Abstract:Intratumour heterogeneity is often associated with poor response to treatment and bad prognosis. In addition to genetic and epigenetic sources, phenotypic heterogeneity can also reflect plastic responses to signals from other cells. The latter can be mediated by various cell-cell interactions, from antagonistic (i.e., competition) to commensalistic or cooperative (mutually beneficial or altruistic). Positive exchanges can increase the fitness of clones and contribute to tumour growth, resistance to drugs and m… Show more
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