.&lt;/strong&gt; &lt;em&gt;&lt;strong&gt;ARTEMISIA&lt;/strong&gt;&lt;/em&gt; &lt;strong&gt;SPECIES IN TRADITIONAL CHINESE MEDICINE AND THE DISCOVERY OF ARTEMISININ&lt;/strong&gt;

Yu, Hongwen; Zhong, Shouming

doi:10.4324/9780203303061_chapter_9

Cited by 7 publications

(6 citation statements)

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“…These will be briefly discussed below as they illustrate some of the difficulties and limitations typical of many of the trials carried out with herbal antimalarials. In 1992 in China, 144 malaria patients were treated with tablets containing an ethanolic extract of A. annua or with capsules in which the extract was formulated in oil (Yao-De et al, 1992, reviewed in Yu andZhong, 2002). The treatments were found to be effective in reducing parasitaemia and fever at doses equivalent to 80.8 g raw herb for the tablets and 73.6 g for the capsules, given over 3 days.…”

Section: Clinical Trials With Traditional Antimalarialsmentioning

confidence: 96%

Plant Derived Antimalarial Agents: New Leads and Challenges

Wright

2005

Phytochem Rev

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New treatments for malaria are urgently needed due to the increasing problem of drug-resistance in malaria parasites. The long-established use of quinine and the more recent introduction of artemisinin and its derivatives as highly effective antimalarials demonstrates that plant species are an important resource for the discovery of new antimalarial agents. Furthermore, many plant species continue to be used in traditional medicines for the treatment of malaria and many people depend on such remedies as they cannot afford and/or do not have access to effective antimalarial drugs. In this paper the potential of plant species to yield new leads to antimalarial drugs will be illustrated with reference to cryptolepine, the main alkaloid present in the species, Cryptolepis sanguinolenta. In addition to this approach, there is currently increasing interest in the use and development of traditional herbal remedies for the treatment of malaria as these may have the potential to provide affordable antimalarial treatment for many who cannot afford the drugs needed to treat chloroquine-resistant Plasmodium falciparum infections. However, little is known with respect to the efficacy and safety of traditional antimalarials and clinical studies are urgently needed to establish their value. Some of the issues pertinent to this area will be briefly reviewed and it is hoped that this will stimulate further discussion and research on this important topic.

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Section: Clinical Trials With Traditional Antimalarialsmentioning

confidence: 96%

Plant Derived Antimalarial Agents: New Leads and Challenges

Wright

2005

Phytochem Rev

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“…Recently, we have seen a number of plant-derived drugs inspired by local or traditional uses bringing about significant improvements in the treatment of various conditions, such as Alzheimer's disease, malaria and AIDS. These include galanthamine (Heinrich & Lee Teoh 2004), artemisinin (Yu & Zhong 2002) and prostratin (Cox 2001).…”

Section: Introductionmentioning

confidence: 99%

Historical and modern medicinal plant uses — the example of the Ch'orti‘ Maya and Ladinos in Eastern Guatemala

Kufer

Förther

Pöll

et al. 2005

Journal of Pharmacy and Pharmacology

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Local empirical knowledge about medicinal properties of plants is the basis for their use as home remedies. Particularly in developing countries such remedies still are an indispensable resource for everyday health care. They form the basis for numerous studies on drugs from natural sources. Like other indigenous groups across the world, the Ch'orti' Maya in Eastern Guatemala are currently experiencing a phase of dramatic cultural change, with their traditional knowledge about plants being in great danger of disappearing. During 17 months of fieldwork, medicinal plant uses were documented using a semi-quantitative approach and analysed using ethnopharmacological methods. The most important groups of illnesses treated with plants were gastrointestinal complaints and illnesses associated with pain and fever. Field data were compared with mostly unpublished historical data collected in the 1930s by the anthropologist Charles Wisdom. This comparison showed that medicinal plant uses that are more consistent over time are also shared by a larger number of people. A literature search on the most frequently mentioned medicinal plants showed that, even for widely used medicinal species, phytochemical and pharmacological data are insufficient for fully understanding their therapeutic profile. Whereas a few examples of potentially dangerous practices were encountered, the limited amount of information available mostly supports local medicinal plant usage.

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“…In the 16 th century, Li Shizhen, writer of the "Classified Materia Medica", stated that A. annua was a remedy for malaria associated with fevers and chills. The Traditional Chinese Medicine recognised Artemisia as having cold and cooling properties useful in relieving heat syndromes (fevers) with a detoxicant effect (Yu and Zhong, 2002;Hsu, 2006: 667ff ). 4 Because artemisinin itself has physical properties such as poor bioavailability that limit its effectiveness, semi-synthetic derivates of artemisinin have been developed.…”

Section: Notes Endnotesmentioning

confidence: 99%