<strong>Late-Stage Sequential </strong><strong>C-H Functionalization of </strong><strong>Thiazolo[5,4-<em>f</em>]quina-zolin</strong><strong>-9(8<em>H</em>)-</strong><strong>one: Synthesis of a Library of Potential Kinase Inhibitors</strong>
Abstract:Mono-and bis-(hetero)-arylation of thiazolo[5,4-f]quinazolin-9(8H)-one backbone involving sequential activation of C-H bonds has been developed to furnish the corresponding mono-or diarylated valuable scaffolds. This strategy allows the regioselective C2-H and C7-H arylation by a judicious choice of coupling partners and bases. Differently substituted N 8-benzylated-2,7-diaryl-thiazoloquinazolin-9(8H)ones were thereby obtained in a facile manner. A one-pot procedure was also developed. These protocols provide … Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.