&lt;strong&gt;HIGH-RESOLUTION DEAN FLOW FRACTIONATION (HiDFF): A NOVEL DEAN MIGRATION PHENOMENON FOR SMALL MICROPARTICLE SEPARATION&lt;/strong&gt;

Tay, Hui Min; Kharel, Sharad; Loo, Say Chye Joachim; Hou, Han Wei

doi:10.3390/optofluidics2017-04498

Cited by 1 publication

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“…From Table 1, sedimentation and bifurcation effect techniques could deal with undiluted whole blood samples and achieved good separation efficiencies, but the separated plasma amounts are limited [106][107][108][109][110][111][112][113][114]. Dean vortex effect methods could only process the diluted blood samples due to the limitation of viscosity and velocity of the fluid in the spiral microchannel, although they have good efficiencies and short separation times [115][116][117][118][119][120][121][122]. In wettability control technologies, pure plasma could be extracted from whole blood successfully, but separation time is comparably long, and surface modification is a complex process in microchannel fabrication [123][124][125][126][127].…”

Section: Discussion and Future Directionmentioning

confidence: 99%

Blood Plasma Self-Separation Technologies during the Self-Driven Flow in Microfluidic Platforms

et al. 2021

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Blood plasma is the most commonly used biofluid in disease diagnostic and biomedical analysis due to it contains various biomarkers. The majority of the blood plasma separation is still handled with centrifugation, which is off-chip and time-consuming. Therefore, in the Lab-on-a-chip (LOC) field, an effective microfluidic blood plasma separation platform attracts researchers’ attention globally. Blood plasma self-separation technologies are usually divided into two categories: active self-separation and passive self-separation. Passive self-separation technologies, in contrast with active self-separation, only rely on microchannel geometry, microfluidic phenomena and hydrodynamic forces. Passive self-separation devices are driven by the capillary flow, which is generated due to the characteristics of the surface of the channel and its interaction with the fluid. Comparing to the active plasma separation techniques, passive plasma separation methods are more considered in the microfluidic platform, owing to their ease of fabrication, portable, user-friendly features. We propose an extensive review of mechanisms of passive self-separation technologies and enumerate some experimental details and devices to exploit these effects. The performances, limitations and challenges of these technologies and devices are also compared and discussed.

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