<strong>Antiviral Activity of Fluorinated Heterocyclic Compounds</strong>

Abstract

Nucleoside analogues have a special place among the most effective antiviral drugs and the study of fluorinated nucleoside sugars has led to the development of novel promising chemotherapeutic agents. Our work is dedicated to the determination of cytotoxicity and antiviral activity towards HSV-1, HSV-2 and HAdV5 of such modified nucleosides. Human adenovirus (HAdV) are ubiquitous infectious DNA viruses possessing a broad spectrum of pathogenicity. More than 60 HAdV serotypes have been identified that are responsible for respiratory, gastrointestinal, and ocular diseases. HAdV are able to persist in humans for a long time in latent state and can be reactivated by various factors, especially grave problems they cause immunocompromised hosts by the development of generalized HAdV infection. The diseases caused by Herpes Simplex virus are widely distributed. Treatment of these infections is the most significant medical problem. However, the appearance of resistant virus is current problem in the treatment of patients and deficiency in the antiviral preparations caused their toxicity. Therefore, it is very important to develop new antiviral drugs against this virus.

Fluorinated triazoles as privileged potential candidates in drug development—focusing on their biological and pharmaceutical properties

“…Biliavska and coworkers synthesized fluorinated 1,2,3-triazole 164 ( Supplementary Table S1 ) ( Biliavska et al, 2017 ) and reported them as novel promising chemotherapeutic agents. Using MTT test at concentrations of 50 μg/ml, it was observed that 164 suppressed HSV-1/US reproduction by 50%.…”