&lt;p&gt;Virulence Factors Of Carbapenem-Resistant &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; In Hospital-Acquired Infections In Mansoura, Egypt&lt;/p&gt;

El-Mahdy, Rasha H.; El-Kannishy, Ghada

doi:10.2147/idr.s222329

Cited by 31 publications

(53 citation statements)

References 36 publications

(51 reference statements)

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“…24 It is suggested that the rise in resistance to anti-pseudomonal antibiotics, especially carbapenems, aminoglycosides, and fluoroquinolones has contributed to the emergence of P. aeruginosa MDR/ XDR strains, posing a serious and critical therapeutic situation. 20 Urine was the main type of specimen from which isolates were collected, representing almost 67%, as in previous studies from Egypt and Iraq (both 100%), and from Saudi Arabia (88.9%), thus showing the difficulty in managing urinary tract infections secondary to MDR P. aeruginosa. Different results were found in other areas, such as in Lebanon, with a lower rate of MDR P. aeruginosa (30%).…”

Section: Discussionmentioning

confidence: 63%

High Rates of Aminoglycoside Methyltransferases Associated with Metallo-Beta-Lactamases in Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Clinical Isolates from a Tertiary Care Hospital in Egypt

El-Far¹,

Samir²,

El-Gebaly³

et al. 2021

IDR

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Section: Discussionmentioning

confidence: 63%

High Rates of Aminoglycoside Methyltransferases Associated with Metallo-Beta-Lactamases in Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Clinical Isolates from a Tertiary Care Hospital in Egypt

El-Far¹,

Samir²,

El-Gebaly³

et al. 2021

IDR

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“…The pathogenesis of P . aeruginosa is attributed to a variety of virulence factors, such as the cytotoxic pigment pyocyanin, the major siderophore pyoverdine, alkaline protease, elastase, exotoxins, flagella, and biofilm formation [ 4 ]. In addition, core genome analyses have revealed a distinct set of P .…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Analysis of Pseudomonas aeruginosa Response to Pine Honey via RNA Sequencing Indicates Multiple Mechanisms of Antibacterial Activity

Kafantaris

Tsadila

Nikolaidis

et al. 2021

Foods

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Pine honey is a unique type of honeydew honey produced exclusively in Eastern Mediterranean countries like Greece and Turkey. Although the antioxidant and anti-inflammatory properties of pine honey are well documented, few studies have investigated so far its antibacterial activity. This study investigates the antibacterial effects of pine honey against P. aeruginosa PA14 at the molecular level using a global transcriptome approach via RNA-sequencing. Pine honey treatment was applied at sub-inhibitory concentration and short exposure time (0.5× of minimum inhibitory concentration –MIC- for 45 min). Pine honey induced the differential expression (>two-fold change and p ≤ 0.05) of 463 genes, with 274 of them being down-regulated and 189 being up-regulated. Gene ontology (GO) analysis revealed that pine honey affected a wide range of biological processes (BP). The most affected down-regulated BP GO terms were oxidation-reduction process, transmembrane transport, proteolysis, signal transduction, biosynthetic process, phenazine biosynthetic process, bacterial chemotaxis, and antibiotic biosynthetic process. The up-regulated BP terms, affected by pine honey treatment, were those related to the regulation of DNA-templated transcription, siderophore transport, and phosphorylation. Pathway analysis revealed that pine honey treatment significantly affected two-component regulatory systems, ABC transporter systems, quorum sensing, bacterial chemotaxis, biofilm formation and SOS response. These data collectively indicate that multiple mechanisms of action are implicated in antibacterial activity exerted by pine honey against P. aeruginosa.

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“…Figure5Summary of the prevalence (%) of carbapenemase genes in P. aeruginosa. Notes: Data from references37,40,[44][45][46][47]49,51,80,[85][86][87][88][89][90][91][92] . a % of MBL-producing P. aeruginosa; b % of P. aeruginosa isolates resistant to one or more β-lactams; c % of XDR-CRPA; d % of imipenem-resistant P. aeruginosa; e % of carbapenemase genes…”

mentioning

confidence: 99%

Landscape of Multidrug-Resistant Gram-Negative Infections in Egypt: Survey and Literature Review

El-Kholy¹,

El-Mahallawy²,

Elsharnouby³

et al. 2021

IDR

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This article is the first to review published reports on the prevalence of multidrugresistant (MDR) gram-negative infections in Egypt and gain insights into antimicrobial resistance (AMR) surveillance and susceptibility testing capabilities of Egyptian medical centers. Materials and Methods: A literature review and online survey were conducted. Results: The online survey and literature review reported high prevalence of extendedspectrum β-lactamase (ESBL)-producing Enterobacteriaceae (19-85.24% of E. coli, and 10-87% of K. pneumoniae), carbapenem-resistant Enterobacteriaceae (35-100% of K. pneumoniae and 13.8-100% of E. coli), carbapenem-resistant Acinetobacter baumannii (10-100%), and carbapenem-resistant Pseudomonas aeruginosa (15-70%) in Egypt. Risk factors for MDR Gram-negative infections were ventilated patients (67.4%), prolonged hospitalization (53.5%) and chronic disease (34.9%). Although antimicrobial surveillance capabilities were deemed at least moderate in most centers, lack of access to rapid AMR diagnostics, lack of use of local epidemiological data in treatment decision-making, lack of antimicrobial stewardship (AMS) programs, and lack of risk prediction tools were commonly reported by respondents. Conclusion:This survey has highlighted the presence of knowledge gaps as well as limitations in the surveillance and monitoring capabilities of AMR in Egypt, with most laboratories lacking rapid diagnostics and molecular testing. Future efforts in Egypt should focus on tackling these issues via nationwide initiatives, including understanding the AMR trends in the country, capacity building of laboratories and their staff to correctly and timely identify AMR, and introducing newer antimicrobials for targeting emerging resistance mechanisms in Gram-negative species.

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<p>Virulence Factors Of Carbapenem-Resistant <em>Pseudomonas aeruginosa</em> In Hospital-Acquired Infections In Mansoura, Egypt</p>

Cited by 31 publications

References 36 publications

High Rates of Aminoglycoside Methyltransferases Associated with Metallo-Beta-Lactamases in Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Clinical Isolates from a Tertiary Care Hospital in Egypt

High Rates of Aminoglycoside Methyltransferases Associated with Metallo-Beta-Lactamases in Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Clinical Isolates from a Tertiary Care Hospital in Egypt

Transcriptomic Analysis of Pseudomonas aeruginosa Response to Pine Honey via RNA Sequencing Indicates Multiple Mechanisms of Antibacterial Activity

Landscape of Multidrug-Resistant Gram-Negative Infections in Egypt: Survey and Literature Review

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