&lt;p&gt;Upregulation Of circMMP9 Promotes Osteosarcoma Progression Via Targeting miR-1265/CHI3L1 Axis&lt;/p&gt;

Pan, Guangjie; Hu, Ting; Chen, Xuewu; Zhang, Chao

doi:10.2147/cmar.s226264

Cited by 27 publications

(34 citation statements)

References 27 publications

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“…Emerging studies have shown that circRNAs play a crucial role in regulating cell growth, cell cycle, cell apoptosis, cell migration, and cell metabolism in a series of cancer types, including OS [12]. For example, Pan et al found that circMMP9 promotes OS progression via targeting the miR-1265/CHI3L1 axis [13]. Zheng et al found that circRNA LRP6 induced OS development via negatively regulating KLF2 expression [14].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR‐218

Lin

Liu

Xiang

et al. 2020

BioMed Research International

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Circular RNAs (circRNAs) play a key role in regulating the tumorigenesis and development of human cancers, including osteosarcoma (OS). Of note, the molecular mechanism underlying the progression of OS has remained largely unclear. The present study identified that a novel circRNA circEIF4G2 was upregulated in OS tissues and cells. Moreover, we constructed a circEIF4G2-mediated ceRNA network and revealed that circEIF4G2 was involved in regulating multiple cancer pathways, such as the EGFR signaling pathway, the PI3K-Akt signaling pathway, and the ErbB signaling pathway. Loss-of-function assays showed that circEIF4G2 knockdown significantly suppressed OS cell proliferation, migration, and invasion. Mechanically, we found that circEIF4G2 could directly bind to miR-218, and miR-218 mediated the effect of circEIF4G2 knockdown on OS progression. In conclusion, the present study showed that circEIF4G2 could be a potential biomarker for OS.

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Section: Introductionmentioning

confidence: 99%

[Retracted] CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR‐218

Lin

Liu

Xiang

et al. 2020

BioMed Research International

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“…Hsa_circ0021347 also showed the same prognostic trend (75). In contrast, research performed by Pan et al (34) suggested that overexpression of circMMP9 was correlated with advanced tumor stage and predicted a low survival rate by KM analysis. Circ_0102049 was remarkably correlated with patients' poor OS analyzed by KM curves in a study of 76 OSA patients (35).…”

Section: Circrna and Osteosarcoma Prognosismentioning

confidence: 84%

Emerging Roles and Potential Biological Value of CircRNA in Osteosarcoma

Liu

Yang

et al. 2020

Front. Oncol.

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Circular RNAs (circRNAs) are endogenous noncoding RNAs that are widely found in eukaryotic cells. They have been found to play a vital biological role in the development of human diseases. At present, circRNAs have been involved in the pathogenesis, diagnosis, and targeted treatment of multiple tumors. This article reviews the research progress of circRNAs in osteosarcoma (OSA) in recent years. The potential connection between circRNAs and OSA cell proliferation, apoptosis, metastasis, and chemotherapy sensitivity or resistance, as well as clinical values, is described in this review. Their categories and functions are generally summarized to facilitate a better understanding of OSA pathogenesis, and findings suggest novel circRNA-based methods may be used to investigate OSA and provide an outlook for viable biomarkers and therapeutic targets.

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“…The circRNA-miRNA-mRNA network has been reported to involve in the mediation of tumorigenesis. 28 Some circRNAs can regulate gene expression via functioning as miRNA sponges. 23 For example, circGRAMD1B sponges miR-130a-3p to inhibit gastric cancer tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

<p>Circular RNA circEXOC6B Inhibits the Progression of Ovarian Cancer by Sponging miR-421 and Regulating RUS1 Expression</p>

Wang¹,

Zhang²,

Fang³

et al. 2020

OTT

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Background: Evidence has been shown that circular RNAs (circRNAs) play a vital role during the development of ovarian cancer. However, the mechanism by which circEXOC6B regulates tumorigenesis of ovarian cancer remains unknown. Thus, this study aimed to investigate the role of circEXOC6B during the progression of ovarian cancer. Materials and Methods: The dual-luciferase reporter system assay was used to determine the interaction between circEXOC6B, miR-421 and RUS1 in ovarian cancer, respectively. CCK8 and colony formatting were used to evaluate cell proliferation. Meanwhile, the expressions of RSU1, PINCH1 and ILK in SKOV3 cells were detected with Western blot. Results: Downregulation of circEXOC6B markedly promoted the proliferation and invasion in A2780 cells. In contrast, upregulation of circEXOC6B significantly inhibited the proliferation and invasion in SKOV3 cells. Moreover, overexpression of circEXOC6B obviously induced the apoptosis of SKOV3 cells. Furthermore, luciferase reporter assay identified that miR-421 was the potential miRNA binding of circEXOC6B, and RUS1 was the potential binding target of miR-421. Mechanism analysis indicated that upregulation of circEXOC6B increased the level of RUS1 by acting as a competitive "sponge" of miR-421. Conclusion: In this study, we found that circEXOC6B suppressed the growth of ovarian cancer cells through upregulating RSU1 partially via sponging miR-421. Therefore, circEXOC6B might be a potential target for the treatment of ovarian cancer.

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<p>Upregulation Of circMMP9 Promotes Osteosarcoma Progression Via Targeting miR-1265/CHI3L1 Axis</p>

Cited by 27 publications

References 27 publications

[Retracted] CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR‐218

[Retracted] CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR‐218

Emerging Roles and Potential Biological Value of CircRNA in Osteosarcoma

<p>Circular RNA circEXOC6B Inhibits the Progression of Ovarian Cancer by Sponging miR-421 and Regulating RUS1 Expression</p>

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