<p>The Role of Methyltransferase NSD2 as a Potential Oncogene in Human Solid Tumors</p>

Abstract

Malignant solid tumors are the leading cause of death in humans, and epigenetic regulation plays a significant role in studying the mechanism of human solid tumors. Recently, histone lysine methylation has been demonstrated to be involved in the development of human solid tumors due to its epigenetic stability and some other advantages. The 90-kb protein methyltransferase nuclear receptor SET domain-containing 2 (NSD2) is a member of nuclear receptor SET domain-containing (NSD) protein lysine methyltransferase (KMT) family, which can cause epigenomic aberrations via altering the methylation states. Studies have shown that NSD2 is frequently over-expressed in multiple types of aggressive solid tumors, including breast cancer, renal cancer, prostate cancer, cervical cancer, and osteosarcoma, and such up-regulation has been linked to poor prognosis and recurrence. Further studies have identified that over-expression of NSD2 promotes cell proliferation, migration, invasion, and epithelial-mesenchymal transformation (EMT), suggesting its potential oncogenic role in solid tumors. Moreover, Gene Expression Profiling Interactive Analysis (GEPIA) was searched for validation of prognostic value of NSD2 in human solid tumors. However, the underlying specific mechanism remains unclear. In our present work, we summarized the latest advances in NSD2 expression and clinical applications in solid tumors, and our findings provided valuable insights into the targeted therapeutic regimens of solid tumors.

METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy

“…Owing to its potent role in epigenetic regulation, NSD2 has been reported to play important roles in human solid tumors by regulating DNA damage repair and epithelial–mesenchymal transition process [ 27 ]. During tumor growth, reprogrammed glucose metabolism is involved to meet the demand of glycolytic intermediates for macromolecule biosynthesis, during which the NSD2 has been reported to play a role by regulating key glucose metabolism regulators, such as TIGAR, HK2, and G6PD [ 28 ].…”

Histone Methyltransferases Useful in Gastric Cancer Research

“…This overexpression is associated with poor prognosis and recurrence. 43 These findings reveal the qualitative relationship between genetic variation of HMT and its downstream effect, especially for oncogenes and tumor suppressor genes, which have been critical for prevention, diagnosis, and treatment of cancer. All of the HMTs presented here could be a potential panel of prognostic biomarker, especially the HMTs encoded for PRDM9, SETDB1, PRDM14, EHMT2, and NSD3 genes.…”

miR-154 Influences HNSCC Development and Progression through Regulation of the Epithelial-to-Mesenchymal Transition Process and Could Be Used as a Potential Biomarker

“…Moreover, lower levels of NSD2 caused a higher expression of the E-cadherin protein and decreased N-cadherin as well as vimentin. NSD2 interacts with TWIST1 and causes upregulation of H3K36me2, which, in turn, is manifested with EMT promotion [ 103 ].…”