&lt;p&gt;The role of long noncoding RNA in traumatic brain injury&lt;/p&gt;

Long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) play an important role in central nervous diseases; however, the exact expression and co-expressed profiles in human traumatic brain injury (TBI) are still unknown. Therefore, we investigated whole blood in 12 patients with TBI and 4 healthy controls to observe expression characteristics with different severity. We identified 3,035 lncRNAs and 1,204 mRNAs differentially expressed in the severe TBI group, 2,362 lncRNAs and 656 mRNAs in the moderate group, and 433 lncRNAs and 100 mRNAs in the mild group. Enrichment analyses showed 30 signaling pathways such as inflammatory and immune response pathways. Subsequently, a lncRNA-gene co-expression network was generated for 717 lncRNA-mRNA pairs and most of them with a positive correlation. Based on GSEA analysis, we found that TBI caused severe immune abnormality reflected on Th1, Th2, and Th17 cell differentiation deficiency. Finally, the expression of one upregulated and one downregulated lncRNA was validated in all three TBI groups, which was consistent with the microarray results. In summary, our results show that expression profiles of lncRNAs and mRNAs are significantly different in bloods from different severity TBI especially in immune response, providing novel insight for lncRNAs in human TBI.

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“… 24 A series of lncRNAs in the injured cortex in TBI mice were altered, which may be involved in different pathologies. 14 …”

Section: Discussionmentioning

confidence: 99%

“… 13 Recently, Li et al. 14 identified a series of lncRNAs that are statistically altered in the injured cortex in TBI mice.…”

Section: Introductionmentioning

confidence: 99%

Expression Profiles of Long Non-coding RNA and Messenger RNA in Human Traumatic Brain Injury

Ren

Chen

Cao

et al. 2020

Molecular Therapy - Nucleic Acids

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“…Repression of CRNDE also promoted the expression of differentiation markers in neurons and the directional growth and regeneration of nerve fibers (Yi et al 2019). Other lncRNAs that have a reported function in TBI are NEAT1, MEG3, MALAT1, Gm4419, and lincRNA-p21 (Li et al 2019a;Zhang and Wang 2019).…”

Section: Lncrnas In Traumatic Brain Injurymentioning

confidence: 99%

“…lncRNA dysregulation after TBI was observed in the cerebral cortex and hippocampus (Zhong et al 2016;Wang et al 2017). The current progress of studies on lncRNAs in TBI was recently reviewed (Zhang and Wang 2019;Li et al 2019a), so we will mention only few examples that were recently published. Gas5 was found using microarrays to be induced in the rat hippocampus after TBI (Wang et al 2017).…”

Section: Lncrnas In Traumatic Brain Injurymentioning

confidence: 99%

Long Noncoding RNAs in Development and Regeneration of the Neural Lineage

Hezroni

Perry

Ulitsky

2019

Cold Spring Harb Symp Quant Biol

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Long noncoding RNAs (lncRNAs) are gathering increasing attention toward their roles in different biological systems. In mammals, the richest repertoires of lncRNAs are expressed in the brain and in the testis, and the diversity of lncRNAs in the nervous system is thought to be related to the diversity and the complexity of its cell types. Supporting this notion, many lncRNAs are differentially expressed between different regions of the brain or in particular cell types, and many lncRNAs are dynamically expressed during embryonic or postnatal neurogenesis. Less is known about the functions of these genes, if any, but they are increasingly implicated in diverse processes in health and disease. Here, we review the current knowledge about the roles and importance of lncRNAs in the central and peripheral nervous systems and discuss the specific niches within gene regulatory networks that might be preferentially occupied by lncRNAs.

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“…Treatment with antagomiR for miR‐21 or antagomiRs for miR‐23a and miR‐27a were shown to target the expression of neural apoptosis, leading to better neuronal survival after TBI (Ge et al, ; Sabirzhanov et al, ). LncRNAs as a large type of ncRNAs have also been indicated to be associated with multiple pathophysiological processes such as neuroinflammation, oxidative stress, neurodegeneration, apoptosis, ischemia, and hypoxia following CNS injuries (Li, Han, et al, ). Although the regulatory mechanism requires to be further discovered, lncRNAs were commonly found to activate or inhibit some signaling pathways via sponging miRNAs (Dai, Yi, Wang, Chen, & Xu, ).…”

Section: Introductionmentioning

confidence: 99%

The emerging roles of circular RNAs in CNS injuries

Liu

Chen

et al. 2020

J of Neuroscience Research

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With high morbidity and mortality worldwide, injuries to the central nervous system (CNS) usually result in devastating consequences. However, the underlying mechanisms have not been fully understood and current therapies are still limited.Circular RNA (circRNA) is a novel type of endogenous noncoding RNAs, characterized by covalently closed annular structure. It is gradually recognized that circRNAs are involved in multiple biological processes, such as acting as microRNA sponges or scaffolds during the assembly of protein complex and modulating the transcription of certain genes. Interestingly, circRNAs have been found to be highly expressed in the CNS, which indicates their neurospecificity. Several circRNAs have already been discovered to be associated with multiple pathophysiological processes following neurological diseases. Currently, the molecular roles of circRNAs in CNS injuries have gained increasing attention, leading to uninterrupted relevant researches. Herein, we presented a review of current studies on the role of circRNAs in CNS injuries. The therapeutic potency of circRNAs in CNS injuries was also analyzed. K E Y W O R D S circular RNA, spinal cord injury, stroke, traumatic brain injury S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. Transparent Peer Review Report How to cite this article: Qu X, Li Z, Chen J, Hou L. The emerging roles of circular RNAs in CNS injuries. J Neuro Res.

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<p>The role of long noncoding RNA in traumatic brain injury</p>

Cited by 22 publications

References 58 publications

Expression Profiles of Long Non-coding RNA and Messenger RNA in Human Traumatic Brain Injury

Expression Profiles of Long Non-coding RNA and Messenger RNA in Human Traumatic Brain Injury

Long Noncoding RNAs in Development and Regeneration of the Neural Lineage

The emerging roles of circular RNAs in CNS injuries

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