&lt;p&gt;The Risk of Cerebrovascular Accidents in Inflammatory Bowel Disease in the United States: A Population-Based National Study&lt;/p&gt;

Ghoneim, Sara; Shah, Aun R.; Dhorepatil, Aneesh; Butt, Muhammad; Waghray, Nisheet

doi:10.2147/ceg.s250182

Cited by 8 publications

(8 citation statements)

References 34 publications

(49 reference statements)

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“…In contrast, according to a meta-analysis by Sighn et al, the incidence of ATE (including all IHD, CVD, and peripheral ATE) in Western IBD patients was 5.92% (9,050 of 152,756 IBD patients) 11 , which was higher than in our study. Several recent reports have suggested that IBD patients in Western countries had a 1.18-to 8.07-fold higher risk of ATE, including IHD and CVD, than non-IBD patients [9][10][11]. These findings suggest that the incidence of IBD-associated ATE markedly differs between Asian and Western countries.…”

Section: Discussionmentioning

confidence: 89%

“…The mortality of IBD patients with TE was 0.019% among all IBD patients (annual mortality due to TE: 1.88 per 100,000 personyears) and 1.0% among IBD patients with TE, which was not higher than that in general population. Regarding ATE, a meta-analysis in Western countries showed that the mortality of cardiovascular disease in IBD patients was not higher than that in the general population [8], although the risk of ATE in IBD patients has been reported to be higher than that in non-IBD controls [9][10][11]. These findings suggest that the incidences of severe ATE and ATE-associated death in IBD patients were not higher than those in the general population in Asian or Western countries.…”

Section: Discussionmentioning

confidence: 92%

“…In recent years, several reports have suggested that IBD patients have an increased risk of arterial thromboembolism (ATE), including ischemic heart disease (IHD) and cerebrovascular disease (CVD), compared with non-IBD patients [9][10][11]. Notably, ATE and VTE are regarded as life-threatening complications of IBD in clinical practice due to the potential need for invasive therapy (admission to the intensive care unit, catheter intervention, and surgery) and consequences of severe organ failure and death [1].…”

Section: Introductionmentioning

confidence: 99%

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A nationwide survey concerning the mortality and risk of progressing severity due to arterial and venous thromboembolism in inflammatory bowel disease in Japan

et al. 2021

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Background The mortality and risk factors of severe disease and death due to arterial and venous thromboembolism (ATE and VTE, respectively) in patients with inflammatory bowel disease (IBD) remain unclear, especially in Asia. Aims This study aimed to reveal the mortality and risk factors of TE in IBD patients in Japan. Methods In the primary surveillance, responses to questionnaires regarding the number of cases of severe TE and TE-associated death in IBD patients in a span of over the past 10 years were obtained from 32 institutions in Japan. In the secondary surveillance, detailed data about IBD patients with TE were collected. The characteristics, laboratory data, therapy status, and situation at the time of TE development were retrospectively collected, and the data were compared between the patients with and without severe TE and TE-associated death. Results The incidence of TE was 1.89% among 31,940 IBD patients. The frequencies of severe TE and TE-associated mortality were 10.7% and 1.0% among the total IBD and TE with IBD patients, respectively. The only risk factor for severe ATE and ATE-associated death was ischemic heart disease. The independent risk factors for severe VTE and VTE-associated death were age (≤ 45 years old), the site of VTE, and disease severity, with anti-TNF therapy as a potential negative risk factor. Patients with severe VTE had a high risk of developing persistent VTE and sequelae. Conclusion Unlike ATE, the incidence of VTE was comparable in Asian and Western countries. Therapeutic and prophylactic strategies for managing IBD-associated TE in Asia are urgently needed.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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A nationwide survey concerning the mortality and risk of progressing severity due to arterial and venous thromboembolism in inflammatory bowel disease in Japan

et al. 2021

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“…Low-grade systemic inflammation worsens cardiovascular diseases ( Dhorepatil et al, 2019 ; Ghoneim et al, 2020a , b ). It triggers/heightens an endothelial inflammatory response in the coronary microvasculature ( Paulus and Tschope, 2013 ).…”

Section: Effects Of Obesity On the Heartmentioning

confidence: 99%

Diabetes Mellitus and Heart Failure With Preserved Ejection Fraction: Role of Obesity

et al. 2022

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Heart failure with preserved ejection fraction is a growing epidemic and accounts for half of all patients with heart failure. Increasing prevalence, morbidity, and clinical inertia have spurred a rethinking of the pathophysiology of heart failure with preserved ejection fraction. Unlike heart failure with reduced ejection fraction, heart failure with preserved ejection fraction has distinct clinical phenotypes. The obese-diabetic phenotype is the most often encountered phenotype in clinical practice and shares the greatest burden of morbidity and mortality. Left ventricular remodeling plays a major role in its pathophysiology. Understanding the interplay of obesity, diabetes mellitus, and inflammation in the pathophysiology of left ventricular remodeling may help in the discovery of new therapeutic targets to improve clinical outcomes in heart failure with preserved ejection fraction. Anti-diabetic agents like glucagon-like-peptide 1 analogs and sodium-glucose co-transporter 2 are promising therapeutic modalities for the obese-diabetic phenotype of heart failure with preserved ejection fraction and aggressive weight loss via lifestyle or bariatric surgery is still key to reverse adverse left ventricular remodeling. This review focuses on the obese-diabetic phenotype of heart failure with preserved ejection fraction highlighting the interaction between obesity, diabetes, and coronary microvascular dysfunction in the development and progression of left ventricular remodeling. Recent therapeutic advances are reviewed.

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“…[7][8][9][10] IBD has been considered a potential risk factor for acute arterial events in addition to traditional cardiovascular risk factors. 11,12 However, these studies have mainly focused on hard endpoints such as cardiovascular and cerebrovascular events, and few studies focused on the relationship between IBD and hypertension. Therefore, we analyzed the data from the UK Biobank, a large prospective, population-based and multiple-centered study focusing on genetic and nongenetic risk factors for diseases in general population.…”

Section: Introductionmentioning

confidence: 99%

Ulcerative colitis increases risk of hypertension in a UK biobank cohort study

Zhang

Qiu

et al. 2022

UEG Journal

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Objective Inflammatory bowel disease (IBD) is not only a chronic inflammatory disorder of the gastrointestinal tract but also accompanied by systemic inflammation. The onset of hypertension is closely related to systemic inflammation. However, the relationship between IBD and hypertension has not been investigated. We aimed to investigate the potential association between IBD and the incidence of hypertension. Method We retrieved IBD onset and the incidence of hypertension from a public database UK Biobank. The association between the onset of IBD and subsequent incidence of hypertension was analyzed using a multivariate Cox regression analysis, and propensity score matching was performed for sensitivity analysis. Result Of a total of 281,064 participants included in the study, 2376 (0.8%) were diagnosed with IBD at baseline, and 20,129 (7.2%) in the whole cohort developed hypertension with a median follow‐up duration of 8.1 years (interquartile range [IQR] 7.3–8.8 years). Patients with IBD had a higher cumulative risk of hypertension compared with general population (10.9% in ulcerative colitis [UC], 7.7% in Crohn's disease [CD], and 9.3% in IBD unclassified [IBD‐U] vs. 7.1% in non‐IBD, p < 0.001). Multivariate Cox regression analysis identified that UC, rather than CD or IBD‐U, was independently associated with subsequent occurrence of hypertension (HR 1.30, 95% CI: 1.11–1.52, p = 0.001). In propensity matching analysis, UC also showed its robustness as a risk factor for the prediction of hypertension (HR 1.56, 95% CI: 1.21–2.03, p = 0.001). Conclusion In IBD patients, UC rather than CD is associated with a higher risk for the incidence of hypertension compared with general population. Close monitoring of hypertension might be required in clinical practice.

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<p>The Risk of Cerebrovascular Accidents in Inflammatory Bowel Disease in the United States: A Population-Based National Study</p>

Cited by 8 publications

References 34 publications

A nationwide survey concerning the mortality and risk of progressing severity due to arterial and venous thromboembolism in inflammatory bowel disease in Japan

A nationwide survey concerning the mortality and risk of progressing severity due to arterial and venous thromboembolism in inflammatory bowel disease in Japan

Diabetes Mellitus and Heart Failure With Preserved Ejection Fraction: Role of Obesity

Ulcerative colitis increases risk of hypertension in a UK biobank cohort study

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