<p>The relation between zero-time pretransplant deceased donor renal biopsy and kidney transplant survival</p>

Abstract

Introduction There are several investigations about preimplantation biopsy results in alive donors. However, assessment of the biopsies in deceased donors’ kidney and its correlation with patient survival is limited. In this study, we evaluated the correlation between zero-time pretransplant kidney biopsy and survival of kidney in deceased donors. Patients and methods This was a cohort study conducted at Montaserieh Hospital, Mash-had, between January 2016 and December 2017. We included all brain dead patients who were referred to Montaserieh transplantation center. After vascular anastomosis of kidneys in recipient patients, in the operation room, and de-clumping of vessels, biopsies were taken from upper pole of donated kidney. Blocks of biopsies were evaluated by expert pathologists and then reported. We followed patients for 1 year and compared the pathologic findings and renal survival in them. Results The mean age of deceased donors was 32.32±1.49 years and that of the recipient patients was 36.33±1.27 years. Thirty-eight recipient patients (45.2%) were female and 46 were male (54.8%). The most pathologic pattern in our study was grade I separation, followed by blebs, dilatation, and loss of attenuation. We showed that most of the transplantations were safe after 1-year follow-up (85.7%) without any complications. We observed thrombosis in two cases (2.4%) and rejection of transplantation in ten patients (11.9%). Cox regression analysis showed that end-stage renal disease grade (HR =3.84, 95% CI =2.315–6.348; P <0.0001) and gender of the deceased donors (HR =0.34, 95% CI =0.145–0.797; P =0.013) were related to graft survival rate. Conclusion Only cast feature in pathologic exam was related to graft survival, which is a marker of tissue ischemia. There was no significant correlation between other histological findings and graft survival.

Can Gene Expression Analysis in Zero-Time Biopsies Predict Kidney Transplant Rejection?

“…There are also contradictory results and discrepant conclusions in studies that investigated deceased donor (DD) kidneys. While Tavakkoli et al showed no relationship between histological findings and graft survival in DDs ( 3 ), others reported that histological findings predict early graft function ( 4 ). Even the use of various standard immunohistological examinations in zero-time biopsies did not reveal useful markers that could indicate graft outcome.…”