&lt;p&gt;The Regulatory Mechanism and Biological Significance of Mitochondrial Calcium Uniporter in the Migration, Invasion, Angiogenesis and Growth of Gastric Cancer&lt;/p&gt;

Wang, Xiaofei; Song, Xudong; Cheng, Guang; Zhang, Jingwen; Dong, Liru; Bai, Jie; Luo, Dan; Xiong, Yanjie; Li, Shuang; Liu, Fang; Sun, Yuanyuan; Li, Yuyang; Huang, Yunning

doi:10.2147/ott.s262049

Cited by 17 publications

(12 citation statements)

References 30 publications

(39 reference statements)

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“…By contrast, Tosatto et al suggested that the distinctive role of MCU enhances breast migration progression via a mechanism involving hypoxia-inducible factor-1α (HIF-1α) signalling, and they attributed the indirect effects of MCU on Ca 2+ signalling via SOCE that was observed by Tan et al to the cell line-dependent effect [ 113 ]. Similarly, recent evidence by Wang et al is consistent with Tosatto et al’s finding that MCU-mediated mitochondrial Ca 2+ signals enhance metastatic phenotypes (involving the epithelial-mesenchymal transition process) through a distinctive mechanism via HIF-1α and VEGF (Vascular endothelial growth factor) signalling pathways in gastric cancer [ 115 ]. What remains unanswered is how MCU acts at the molecular level and what the possible complex interplay is between mitochondrial Ca 2+ signalling, SOCE and metastatic cancer.…”

Section: Extracellular Components Of Ca 2+ Signsupporting

confidence: 75%

Deciphering the Role of Ca2+ Signalling in Cancer Metastasis: From the Bench to the Bedside

Alharbi

Zhang

Parrington

2021

Cancers

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Metastatic cancer is one of the major causes of cancer-related mortalities. Metastasis is a complex, multi-process phenomenon, and a hallmark of cancer. Calcium (Ca2+) is a ubiquitous secondary messenger, and it has become evident that Ca2+ signalling plays a vital role in cancer. Ca2+ homeostasis is dysregulated in physiological processes related to tumour metastasis and progression—including cellular adhesion, epithelial–mesenchymal transition, cell migration, motility, and invasion. In this review, we looked at the role of intracellular and extracellular Ca2+ signalling pathways in processes that contribute to metastasis at the local level and also their effects on cancer metastasis globally, as well as at underlying molecular mechanisms and clinical applications. Spatiotemporal Ca2+ homeostasis, in terms of oscillations or waves, is crucial for hindering tumour progression and metastasis. They are a limited number of clinical trials investigating treating patients with advanced stages of various cancer types. Ca2+ signalling may serve as a novel hallmark of cancer due to the versatility of Ca2+ signals in cells, which suggests that the modulation of specific upstream/downstream targets may be a therapeutic approach to treat cancer, particularly in patients with metastatic cancers.

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Section: Extracellular Components Of Ca 2+ Signsupporting

confidence: 75%

Deciphering the Role of Ca2+ Signalling in Cancer Metastasis: From the Bench to the Bedside

Alharbi

Zhang

Parrington

2021

Cancers

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“… 43 , 44 EMT affects the expression of epithelial-calponin and enhances the ability of tumors to adhere to the cell surface, thereby enabling tumor cells invasion and metastases. 45 Fibroblast growth factor receptor-2 (FGFR2) amplification occurs in <10% of GC patients and is associated with lymphatic and venous invasion of the primary lesion, lymph node metastasis, distant metastasis, advanced TNM, and poor prognosis. Patients with FGFR2-amplified GC are particularly prone to complications such as peritoneal (malignant ascites) and/or ovarian metastases or disease recurrence.…”

Section: Importance Of Tumoral Angiogenesis In Gastric Cancermentioning

confidence: 99%

Tumor vessel normalization and immunotherapy in gastric cancer

Shen

et al. 2022

Ther Adv Med Oncol

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Gastric cancer (GC) is a common malignant tumor, and patients with GC have a low survival rate due to limited effective treatment methods. Angiogenesis and immune evasion are two key processes in GC progression, and they act synergistically to promote tumor progression. Tumor vascular normalization has been shown to improve the efficacy of cancer immunotherapy, which in turn may be improved through enhanced immune stimulation. Therefore, it may be interesting to identify synergies between immunomodulatory agents and anti-angiogenic therapies in GC. This strategy aims to normalize the tumor microenvironment through the action of the anti-vascular endothelial growth factor while stimulating the immune response through immunotherapy and prolonging the survival of GC patients.

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“…Mejora el brote de angiogénesis y afecta el fenotipo de la punta de la célula [63] UCM El UCM se relacionó con la activación de los mecanismos TEM y con la expresión de FIH-1α y FCEV. El alto nivel de expresión de UCM en el tumor, estuvo asociado con el estadio avanzado de la TEM y la disminución en la supervivencia de pacientes con CG [64] Helicobacter pylori…”

Section: Her2unclassified

Origen, morfología y significancia clínica de microvesículas de tumor en cáncer gástrico

Сеньчукова

2022

Magna Sci. UCEVA

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El cáncer gástrico (CG) continúa siendo un grave problema oncológico, ocupando el tercer lugar en la estructura de mortalidad por neoplasias malignas. Mejorar los resultados del tratamiento para esta patología, depende en gran medida, de la comprensión de la patogenia y de las características biológicas del CG; incluida la identificación y caracterización de los biomarcadores de diagnóstico, pronóstico, predicción y biomarcadores terapéuticos. Se conoce que la principal causa de muerte por neoplasias malignas y CG, en particular, es la metástasis tumoral. Dado que la angiogénesis es un proceso crítico para el crecimiento tumoral y la metástasis, ahora se considera un marcador importante del pronóstico de la enfermedad y la sensibilidad a la terapia contra el cáncer. En la revisión presentada, se consideran los conceptos modernos de los mecanismos de formación de vasos tumorales y las peculiaridades de su morfología; se resumen datos sobre numerosos factores que influyen en la formación de microvasos tumorales y su papel en la progresión de GC; y se destacan varios enfoques para la clasificación de los vasos tumorales, así como los métodos para evaluar la actividad de la angiogénesis en un tumor. Aquí, también se discuten los resultados de los estudios sobre el significado pronóstico y predictivo de los microvasos tumorales en GC, y se propone para su consideración, una nueva clasificación de microvasos tumorales en GC, basada en su morfología y significado clínico.

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<p>The Regulatory Mechanism and Biological Significance of Mitochondrial Calcium Uniporter in the Migration, Invasion, Angiogenesis and Growth of Gastric Cancer</p>

Cited by 17 publications

References 30 publications

Deciphering the Role of Ca2+ Signalling in Cancer Metastasis: From the Bench to the Bedside

Deciphering the Role of Ca2+ Signalling in Cancer Metastasis: From the Bench to the Bedside

Tumor vessel normalization and immunotherapy in gastric cancer

Origen, morfología y significancia clínica de microvesículas de tumor en cáncer gástrico

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