<p>The Product of Red Blood Cells and Hematocrit Can Be Used as a Novel Indicator of Impaired Fasting Blood Glucose Status</p>

Abstract

Objective To explore whether the red blood cell count multiplied by hematocrit index (RBCHct) in blood routine parameters can indicate the risk of impaired fasting blood glucose (IFG), and whether it is related to insulin resistance and inflammation. Methods In this cross-sectional study, previous history of diabetes was excluded, and people with normal and impaired IFG were included. We use Spearman analysis to evaluate the correlation between RBCHct index and fasting plasma glucose, insulin resistance homeostasis model assessment (HOMA-IR), and hypersensitive C-reactive protein (hs-CRP). Binary logistic regression analysis was used to evaluate the RBCHct index for assessing the potential risk of IFG, and the receiver operating characteristic (ROC) curve was used to evaluate the RBCHct index for diagnosing insulin resistance and chronic low-grade inflammatory efficacy among those with IFG. Results Correlation analysis showed that the RBCHct index and fasting plasma glucose (r=0.088, P=0.003); HOMA-IR (r=0.199, P<0.001); and hs-CRP (r=0.097, P=0.001) were positively correlated. After adjusting for confounding factors, the risk of IFG in the third and fourth quartiles of the RBCHct index increased to 1.889 and 3.048 times. The area under the ROC curve of the RBCHct index for diagnosis of insulin resistance state (HOMA-IR) was 0.695 (p<0.001), and the area under the ROC curve of the RBCHct index for the diagnosis of chronic low-inflammatory state (hs-CRP) was 0.641 (P=0.010). Conclusion The RBCHct index may be a potential indicator for assessing the risk of prediabetes and is closely related to whether the body is in a state of insulin resistance and inflammation under IFG.

Efectos a corto plazo del tratamiento con insulina, sobre losíndices hematimétricos en diabéticos

“…(9) La empaglifozina provoca un incremento de la hemoglobina y el hematocrito (10) y la metformina es capaz de disminuir el estrés oxidativo dentro del glóbulo rojo, lo cual incide directamente en los IH. (11) Con respecto al tratamiento con insulina, existen pocos reportes que den cuenta de los efectos que esta hormona pueda tener sobre el glóbulo rojo de los diabéticos, sin embargo, hay autores que proponen que a partir de los IH se puede predecir, usando un algoritmo matemático, la intolerancia a la glucosa y resistencia a la insulina, (12) lo cual hace pensar que debe existir algún mecanismo que explique este hecho.…”

Packed cell volume and its relation to obesity, gender and smoking status

“…Obesity, metabolic illnesses, cardiovascular diseases, and overall mortality are linked to BFP [11]. Obesity and PCV are risk factors for diseases including diabetes mellitus and cardiovascular disorders [12][13][14][15]. HCT has been implicated in a number of epidemiologic studies as one of the main contributors of blood rheology [12], blood rheological abnormalities associated with obesity are being looked at as one of the potential factors for several co-morbidity because they significantly affect blood flow in the microcirculation [16].…”