&lt;p&gt;The Outcome of Unscreened Population in Colorectal Cancer: The Impact of Sex and Other Determinants on Cancer Stage&lt;/p&gt;

Alyabsi, Mesnad; Sabatin, Fouad; Jazieh, Abdul Rahman

doi:10.2147/cmar.s268823

Cited by 10 publications

(10 citation statements)

References 50 publications

(79 reference statements)

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“…In the multivariable analysis, metastatic patients had 3.86 higher odds of 30-day hospital readmission compared to those with localized disease, similar to previous findings [22,23]. Several studies from Saudi Arabia have shown that a sizable percentage of Saudi CRC patients were diagnosed at an advanced stage [2,9], a risk factor that has been shown to increase readmission in our population. Moreover, we found that patients discharged to locations other than post anesthesia care unit were more likely to be readmitted.…”

Section: Discussionsupporting

confidence: 88%

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The 30-day hospital readmission and mortality after surgery in colorectal cancer patients

et al. 2022

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Purpose Hospital readmissions in the first weeks following surgery are common, expensive, and associated with increased mortality among colorectal cancer patients. This study is designed to assess the 30-day hospital readmission after colorectal cancer surgery and evaluate the risk factors that affect hospital readmission. Methods The study uses data from the Ministry of National Guard-Health Affairs Cancer Registry. All colorectal cancer patients who underwent colorectal cancer surgery between January 1, 2016, and November 31, 2021, were investigated. Factors examined were age, gender, marital status, Body Mass Index, Charlson Comorbidity Index, chemotherapy, radiotherapy, tumor stage, grade, site, surgical approach, length of stay, and discharge location. Kaplan–Meier curves were constructed to assess survival rates between readmitted and non-readmitted patients, and logistic regressions were performed to assess predictors of readmission. Results A total of 356 patients underwent tumor resection and 49 patients were readmitted within 30-day of index discharge. The most common reasons for hospital readmissions were gastrointestinal (22.45%), urinary tract infection (16.33%), and surgical site infection (12.24%). In the multivariable analysis, females were 89% more likely to be readmitted compared to males (odds ratio 1.89, 95% confidence intervals 1.00–3.58). Patients with distant metastatic tumors have higher odds of readmission (odds ratio 4.52, 95% confidence intervals 1.39–14.71) compared to patients with localized disease. Conclusions Colorectal cancer readmission is more common in patients with metastatic disease. Strategies to reduce readmission include planned transition to outpatient care, especially among patients with a high risk of readmission.

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Section: Discussionsupporting

confidence: 88%

“…Whether the rate and predictors of CRC readmissions are the same in the Saudi population remains unknown. This is vital given the poor characteristics of CRC in the Saudi population such as late-stage at diagnosis and low survival [9].…”

Section: Introductionmentioning

confidence: 99%

The 30-day hospital readmission and mortality after surgery in colorectal cancer patients

et al. 2022

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“…A retrospective cohort study assessed data in Saudi Arabia, where there is no population-based CRC screening, to see if there is any association between sex and metastatic CRC adjusting for patient covariates. They found over just one thousand CRC patients, and found that female patients were 20% more likely than males to present with a metastatic tumor (RR = 1.20, 95%CI: 1.04-1.38)[ 57 ]. Their reasoning for this discrepancy was that women had less access to healthcare compared to men.…”

Section: Discussionmentioning

confidence: 99%

Practical considerations for colorectal cancer screening in older adults

Gornick¹,

Kadakuntla²,

Trovato³

et al. 2022

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“…For instance, women with BMI ≥ 23 at age 18 had a 63% higher risk of early-onset CRC compared to women with a BMI of 18.5-20.9 (10). Third, there is currently no population-based screening for CRC in Saudi Arabia, leading to delayed CRC detection, increased late-stage diagnosis, and poor survival across all age groups (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Trends in Colorectal Cancer Incidence Rates in Saudi Arabia (2001–2016) Using Saudi National Registry: Early- Versus Late-Onset Disease

2021

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Early-onset (<50 years old) colorectal cancer (CRC) has been increasing worldwide and is associated with poor outcomes. Over 85% of the Saudi population are <50 years old, which put them at heightened risk of early-onset CRC. No study assessed the trends in CRC incidence rates among the Saudis. The Joinpoint Regression software by the Surveillance, Epidemiology, and End Results (SEER) program was used to estimate the magnitude and direction of CRC incidence trends by age and gender. The annual percentage change (APC) and the average annual percentage change (AAPC) between 2001 and 2016 were computed. In a sensitivity analysis, we also assessed trends using various age groups. Between 2001 and 2016, the early-onset CRC incidence (per 105) increased from 1.32 (95% CI: 1.11, 1.54) to 2.02 (95% CI: 1.83, 2.22) with AAPC (2.6, 95% CI: -0.4, 5.7). At same period, the late-onset incidence increased from 3.54 (95% CI: 3.10, 3.97) to 9.14 (95% CI: 8.62, 9.66) with AAPC (6.1, 95% CI: 3.5, 8.8). Among early-onset CRC patients, age 40–49 has the highest rates and women in this age group has higher rate than men. Our national data showed a gradual increase in CRC incidence rates, which reflect the global concern of early-onset CRC. Further research is needed to understand the etiology of early-onset CRC. Primary health care providers must be alerted about the increasing rate of early-onset CRC. To reduce the future burden of the disease, initiating CRC screening before age 50 is warranted.

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<p>The Outcome of Unscreened Population in Colorectal Cancer: The Impact of Sex and Other Determinants on Cancer Stage</p>

Cited by 10 publications

References 50 publications

The 30-day hospital readmission and mortality after surgery in colorectal cancer patients

The 30-day hospital readmission and mortality after surgery in colorectal cancer patients

Practical considerations for colorectal cancer screening in older adults

Trends in Colorectal Cancer Incidence Rates in Saudi Arabia (2001–2016) Using Saudi National Registry: Early- Versus Late-Onset Disease

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