&lt;p&gt;The Neutrophil to Lymphocyte and Lymphocyte to Monocyte Ratios as New Prognostic Factors in Hematological Malignancies – A Narrative Review&lt;/p&gt;

Stefaniuk, Paulina; Szymczyk, Agnieszka; Podhorecka, Monika

doi:10.2147/cmar.s245928

Cited by 57 publications

(47 citation statements)

References 129 publications

(181 reference statements)

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“…This ratio has been reported as an independent prognostic factor and a value <=1.2 at the diagnosis is associated with shorter time to progression and survival in dogs with DLBCL treated with chemoimmunotherapy ( 32 ). Similar cutoff (1.43) and results were obtained using a lymphocyte-to-monocyte ratio calculated from hematology reports in another study ( 18 ), as also described in human medicine ( 33 , 34 ).…”

Section: Refining the Prognosis Of B-cell Lymphomasupporting

confidence: 80%

Flow Cytometry in the Diagnosis of Canine B-Cell Lymphoma

Riondato

Comazzi

2021

Front. Vet. Sci.

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B cell lymphoma (BCL) is a heterogeneous group of lymphoid malignancies which comprise the majority of canine lymphomas. Diffuse large B cell lymphoma is the most common lymphoma subtype in dogs but other subtypes (e.g., marginal zone lymphoma, follicular lymphoma, mantle cell lymphoma, and others) have been described. This review aims to explore the use of flow cytometry to refine the diagnosis of canine BCL. Particular emphasis will be given to the possible identification of peculiar immunotypes, putative prognostic markers, staging and minimal residual disease.

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Section: Refining the Prognosis Of B-cell Lymphomasupporting

confidence: 80%

Flow Cytometry in the Diagnosis of Canine B-Cell Lymphoma

Riondato

Comazzi

2021

Front. Vet. Sci.

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“…Moreover, neutrophils are involved in the immune response, as an important part of the tumor microenvironment, which plays a central role in cHL pathogenesis [11][12][13]. Neutrophil counts and neutrophil/lymphocyte ratio (NLR) have been proposed as prognostic factors in several solid and hematological tumors, including adults with cHL [14][15][16][17][18][19][20]. A recent study demonstrated that NLR could predict clinical outcomes in PET-negative adult patients with cHL [21].…”

Section: Discussionmentioning

confidence: 99%

A Score for Predicting Freedom from Progression of Children and Adolescents with Hodgkin Lymphoma

Caggiari

Mascarin

et al. 2021

Hemato

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Several studies have examined the prognostic performance of therapeutic groups (TG) and early responses to therapy on positron emission tomography/computed tomography (PET/CT) in children and adolescents with classical Hodgkin lymphoma (cHL); less research has been performed on molecular parameters at diagnosis. The aim of the present study was to devise a scoring system based on the TG criteria for predicting freedom from progression (FFP) in 133 patients: 63.2% males; 14 years median age (interquartile range (IQR) 11.9–15.1); with cHL (108 nodular sclerosis (NS) subtype) treated according to the AIEOP LH-2004 protocol; and median 5.55 (IQR 4.09–7.93) years of follow-up. CHL progressed or relapsed in 37 patients (27.8%), the median FFP was 0.89 years (IQR = 0.59–1.54), and 14 patients (10.5%) died. The FPR (final prognostic rank) model associates the biological HLA-G SNP 3027C/A (numerical point assigned (pt) = 1) and absolute neutrophil count (>8 × 109/L, pt = 2) as variables with the TG (TG3, pt = 3). Results of FPR score analyses for FFP suggested that FPR model (Kaplan–Meier curves, log-rank test for trends) was better than the TG model. At diagnosis, high-risk patients classified at FPR rank 4 and 5 identified 18/22 patients who relapse during the follow-up.

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“…The poor diagnostic utility of the total WCC in ICU patients is a consistent finding [ 19 ]. This is unsurprising given the wide variety of non-infectious mimics, drugs, and comorbidities that influence the total WCC [ 20 – 24 ]. Further, the total WCC may decrease acutely due to sequestration of granulocytes at the site of infection, with a delay in the release of neutrophils from the bone marrow [ 25 ].…”

Section: Current Methods Of Diagnosing Sepsismentioning

confidence: 99%

Host Diagnostic Biomarkers of Infection in the ICU: Where Are We and Where Are We Going?

Heffernan

Denny

2021

Curr Infect Dis Rep

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Purpose of Review Early identification of infection in the critically ill patient and initiation of appropriate treatment is key to reducing morbidity and mortality. On the other hand, the indiscriminate use of antimicrobials leads to harms, many of which may be exaggerated in the critically ill population. The current method of diagnosing infection in the intensive care unit relies heavily on clinical gestalt; however, this approach is plagued by biases. Therefore, a reliable, independent biomarker holds promise in the accurate determination of infection. We discuss currently used host biomarkers used in the intensive care unit and review new and emerging approaches to biomarker discovery. Recent Findings White cell count (including total white cell count, left shift, and the neutrophil-leucocyte ratio), C-reactive protein, and procalcitonin are the most common host diagnostic biomarkers for sepsis used in current clinical practice. However, their utility in the initial diagnosis of infection, and their role in the subsequent decision to commence treatment, remains limited. Novel approaches to biomarker discovery that are currently being investigated include combination biomarkers, host ‘sepsis signatures’ based on differential gene expression, site-specific biomarkers, biomechanical assays, and incorporation of new and pre-existing host biomarkers into machine learning algorithms. Summary To date, no single reliable independent biomarker of infection exists. Whilst new approaches to biomarker discovery hold promise, their clinical utility may be limited if previous mistakes that have afflicted sepsis biomarker research continue to be repeated.

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<p>The Neutrophil to Lymphocyte and Lymphocyte to Monocyte Ratios as New Prognostic Factors in Hematological Malignancies – A Narrative Review</p>

Cited by 57 publications

References 129 publications

Flow Cytometry in the Diagnosis of Canine B-Cell Lymphoma

Flow Cytometry in the Diagnosis of Canine B-Cell Lymphoma

A Score for Predicting Freedom from Progression of Children and Adolescents with Hodgkin Lymphoma

Host Diagnostic Biomarkers of Infection in the ICU: Where Are We and Where Are We Going?

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