<p>The Impact Of Hyperuricemia On Cardiometabolic Risk Factors In Patients With Diabetes Mellitus: A Cross-Sectional Study</p>

Abstract

PurposeHyperuricemia (HUA) is linked to a variety of non-communicable diseases such as atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease (CKD) and hypertension, with evidence showing its role in the development of diabetes mellitus (DM). Our study’s main aim was to explore the associations of HUA with other traditional risk factors in Romanian patients with DM and to assess the impact of the increase of serum UA on DM complications and HbA1c.Patients and methodsIn this cross-sectional, non-interventional study, we enrolled, according to a population-based, consecutive-case principle, 133 patients previously diagnosed with DM. HbA1c, uric acid, lipid profile, urinary albumin/creatinine ratio, glomerular filtration rate, TSH and FT4 measurements were performed, while the diagnosis of retinopathy and of diabetic neuropathy was established using standardized methods.ResultsAn increased uric acid level was associated with a significant increase in the risk for development of stroke (OR=1.526; p=0.004). A weak, positive and statistically significant correlation can also be observed between the BMI and the presence of hyperuricemia (r=0.131; p=0.034), and between the triglyceride levels and hyperuricemia (r= 0.173; p=0.004). Glomerular filtration rate was correlated to hyperuricemia in a strong and negative manner, having an important statistical significance (r=−0.818; p=0.003). In our study, UA levels and HbA1c were negatively correlated, without reaching statistical significance.ConclusionSerum UA is strongly correlated with the BMI, triglyceride level and GFR in Romanian patients with DM and HUA is significantly associated with a higher risk of stroke in these individuals.

Establishment of Clinical Prediction Model Based on the Study of Risk Factors of Stroke in Patients With Type 2 Diabetes Mellitus

“…In this study, eGFR was proved to be a risk factor of stroke in T2DM patients. Based on the discussions above, in a Roman study, eGFR was found to have a strong negative correlation to UA, thus indicating the association between eGFR and risk of stroke among DM patients in terms of the act of UA on stroke incidence ( 52 ). A study implemented in Poland found in a multivariate analysis that eGFR was considered as a risk factor of both diabetic and non-diabetic patients with ischemic stroke ( 53 ).…”

<p>Study on the Risk Factors for Hyperuricaemia and Related Vascular Complications in Patients with Type 2 Diabetes Mellitus</p>

“…A cross-sectional study of cardiovascular metabolic risk factors in HUA diabetic patients showed that serum uric acid levels were closely related to BMI and were in direct proportion. 32,33 In a study by Cuiling Zhu et al, high serum levels were found to be related to severe metabolic abnormalities, including increased BMI. 34 The relationship between UA and BMI mainly showed that the higher the BMI of diabetic patients was, the higher the production of leptin and the more serious the insulin resistance (IR), which would reduce the excretion rate of uric acid, to increase the level of UA.…”

Management of Hyperuricemia in Patients with Chronic Kidney Disease: a Focus on Renal Protection

“…Hyperuricemia has been further linked to an increased risk for stroke as well as other cardiometabolic risk factors including increased BMI and triglycerides in individuals with T2D [28]. Moreover, patients with T2D and hyperuricemia and decreased urinary uric acid excretion are at even more risk for developing CKD; in this particular subgroup, the prevalence of CKD is reported to be 47.8% [29].…”