&lt;p&gt;The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study&lt;/p&gt;

Lichtenberg, Theresa; Stengel, Simon von; Sieber, Cornel; Kemmler, Wolfgang

doi:10.2147/cia.s225618

Cited by 69 publications

(93 citation statements)

References 100 publications

(125 reference statements)

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“…As expected, resistance exercise intervention clearly met the primary endpoint by yielding signi cant improvements in both trunk strength extension and exion. This is in line with current literature (43) and reassuring in terms of the overall study setting and more importantly, it also con rms that appropriate exercise intervention can consistently improve muscular force and performance in a cohort of elderly men.…”

Section: Discussionsupporting

confidence: 88%

Efficacy and safety of simple exercise interventions for men with osteoporosis – a prospective randomized controlled trial

Genest¹,

Lindström²,

Scherer³

et al. 2020

Preprint

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Background: Aging is associated with progressive loss of musculoskeletal performance. Exercise interventions can improve physical function in the elderly but there is a paucity of comparative assessments in order to understand what specific goals can be achieved particularly with less demanding exercise interventions readily accessible for untrained men. Methods: Prospective randomized, controlled, single center trial to compare efficacy and feasibility of four distinct exercise interventions for 6 months in men at risk for osteoporosis aged 65-90 years. Primary endpoint was change in isometric one repetition maximum force trunk strength for extension (TSE) and flexion (TSF) compared to baseline, secondary endpoints covered key parameters of geriatric functional assessment, including Handgrip Strength (HS), Chair-Rise-Test (CRT) Usual Gait Speed (UGS) and Timed-Up-and-Go (TUG).Results: Altogether 47 men (mean age 77 +/-6.1years) were randomized to Resistance Training (RT, n=11), Whole Body Vibration Exercise (WBV, n=13), Qi Gong (QG, n=10) and wearing a Spinal Orthosis (SO, n=13). RT lead to significant improvements for TSE (p=0.009) and TSF (p=0.013). Vibration exercise caused sign. Progress in TSE (p=0.014) and CRT (p=0.005), the Spinal Orthosis improved CRT (p=0.003) and Gait Speed (p=0.027), while the QG Group did not attain any sig. developments. Subgroup analyses revealed most pronounced musculoskeletal progress in vulnerable patients (age ≥80years, pre-sarcopenia, multimorbidity ≥3chronic diseases). Irrespective of the type of exercise, participants ≥80years experienced significant gain in TSE (p=0.029) and CRT (p=0.017). Presarcopenic subjects (Skeletal muscle Index (SMI) ≤10.75 kg/m²) improved in TSE (p=0.003), CRT (p=0.001) and UGS (p=0.016). Multimorbid participants achieved sig. gains in TSE (p<0.001), TSF (p=0.002), UGS (p=0.036) and HS (p=0.046).Conclusions: Simple exercise interventions are feasible in elderly men with specific efficacy, i.e. improvements are attained in those tasks addressed with the training. Consequently, exercise strategies in elderly men should comprise multiple modalities to comprehensively cover various deficits. For vulnerable patients, any simple training appears beneficial.

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Section: Discussionsupporting

confidence: 88%

Efficacy and safety of simple exercise interventions for men with osteoporosis – a prospective randomized controlled trial

Genest¹,

Lindström²,

Scherer³

et al. 2020

Preprint

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“…. based on BIA assessments, 85% of SMI increase in the HIT-RT occurred within the first 28 weeks [14]. This finding indicates that our higher effect on SMI was not based predominately on the longer study duration, however), it nevertheless improved up to the final, i.e., 18-month, FU.…”

Section: Discussionmentioning

confidence: 56%

“…The study was conducted between February 2018 (start of recruitment) and February 2020 (final data analysis). Two recent interim analyses after 6 and 8 months focus on parameters of sarcopenia [14], muscle mass and strength [15], while the 12-month FrOST analysis [16] addressed skeletal muscle mass index and BMD at the lumbar spine (LS) as determined by quantitative computed tomography (QCT).…”

Section: Methodsmentioning

confidence: 99%

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Effects of High Intensity Dynamic Resistance Exercise and Whey Protein Supplements on Osteosarcopenia in Older Men with Low Bone and Muscle Mass. Final Results of the Randomized Controlled FrOST Study

et al. 2020

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The present study aimed to evaluate the effect of high intensity dynamic resistance exercise (HIT-DRT) and whey protein supplementation (WPS) on bone mineral density (BMD) and sarcopenia parameters in osteosarcopenic men. Men ≥ 72 years with osteosarcopenia (n = 43) were randomly assigned to a HIT-RT (HIT-RT: n = 21) or a non-training control group (n = 22). Supervised HIT-RT twice/week was applied for 18 months, while the control group maintained their habitual lifestyle. Supplying WPS, total protein intake amounted to 1.5–1.6 (HIT-RT) and 1.2 g/kg/body mass/d (control). Both groups were supplied with calcium and vitamin D. Primary study outcomes were BMD and the sarcopenia Z-score. After adjusting for multiplicity, we observed significant positive effects for sarcopenia Z-score (standardized mean difference (SMD): 1.40), BMD at lumbar spine (SMD: 0.72) and total hip (SMD: 0.72). In detail, effect sizes for skeletal muscle mass changes were very pronounced (1.97, p < 0.001), while effects for functional sarcopenia parameters were moderate (0.87, p = 0.008; handgrip strength) or low (0.39, p = 0.209; gait velocity). Apart from one man who reported short periods of temporary worsening of existing joint pain, no HIT-RT/WPS-related adverse effects or injuries were reported. We consider HIT-RT supported by whey protein supplementation as a feasible, attractive, safe and highly effective option to fight osteosarcopenia in older men.

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“…The recruitment procedure has been described in detail elsewhere . In brief, individuals of the lowest SMI quartile ( n = 242) from the Franconian Sarcopenic Obesity (FranSO) study ( n = 965) who participated in the 24‐month follow‐up (FU) were contacted.…”

Section: Methodsmentioning

confidence: 99%

Effects of High-Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia—One-Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)

Kemmler

Kohl

Fröhlich

et al. 2020

Journal of Bone and Mineral Research

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Dynamic resistance exercise (DRT) might be the most promising agent for fighting sarcopenia in older people. However, the positive effect of DRT on osteopenia/osteoporosis in men has still to be confirmed. To evaluate the effect of low‐volume/high‐intensity (HIT)‐DRT on bone mineral density (BMD) and skeletal muscle mass index (SMI) in men with osteosarcopenia, we initiated the Franconian Osteopenia and Sarcopenia Trial (FrOST). Forty‐three sedentary community‐dwelling older men (aged 73 to 91 years) with osteopenia/osteoporosis and SMI‐based sarcopenia were randomly assigned to a HIT‐RT exercise group (EG; n = 21) or a control group (CG; n = 22). HIT‐RT provided a progressive, periodized single‐set DRT on machines with high intensity, effort, and velocity twice a week, while CG maintained their lifestyle. Both groups were adequately supplemented with whey protein, vitamin D, and calcium. Primary study endpoint was integral lumbar spine (LS) BMD as determined by quantitative computed tomography. Core secondary study endpoint was SMI as determined by dual‐energy X‐ray absorptiometry. Additional study endpoints were BMD at the total hip and maximum isokinetic hip−/leg‐extensor strength (leg press). After 12 months of exercise, LS‐BMD was maintained in the EG and decreased significantly in the CG, resulting in significant between‐group differences (p < 0.001; standardized mean difference [SMD] = 0.90). In parallel, SMI increased significantly in the EG and decreased significantly in the CG (p < 0.001; SMD = 1.95). Total hip BMD changes did not differ significantly between the groups (p = 0.064; SMD = 0.65), whereas changes in maximum hip−/leg‐extensor strength were much more prominent (p < 0.001; SMD = 1.92) in the EG. Considering dropout (n = 2), attendance rate (95%), and unintended side effects/injuries (n = 0), we believe our HIT‐RT protocol to be feasible, attractive, and safe. In summary, we conclude that our combined low‐threshold HIT‐RT/protein/vitamin D/calcium intervention was feasible, safe, and effective for tackling sarcopenia and osteopenia/osteoporosis in older men with osteosarcopenia. © 2020 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research.

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<p>The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study</p>

Cited by 69 publications

References 100 publications

Efficacy and safety of simple exercise interventions for men with osteoporosis – a prospective randomized controlled trial

Efficacy and safety of simple exercise interventions for men with osteoporosis – a prospective randomized controlled trial

Effects of High Intensity Dynamic Resistance Exercise and Whey Protein Supplements on Osteosarcopenia in Older Men with Low Bone and Muscle Mass. Final Results of the Randomized Controlled FrOST Study

Effects of High-Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia—One-Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST)

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