<p>The Effect Of The Use Of Pre-Emptive Oral Pregabalin On The Postoperative Spinal Analgesia In Patients Presented For Orthopedic Surgeries: Randomized Controlled Trial</p>

Abstract

BackgroundPreoperative oral pregabalin could improve postoperative analgesia and prevent chronic pain development. The aim of this study is to evaluate the effect of oral pregabalin on the duration and quality of postoperative analgesia in spinal anesthesia.MethodsSixty adult patients presented for internal fixation of femoral fracture under spinal anesthesia were included in the study. They were randomly distributed to a placebo group and a pregabalin group receiving 150 mg pregabalin capsules 1 hr before surgery. The onset, duration, and regression of sensory and motor block were recorded. Rescue analgesia consumption, postoperative pain score, and quality of sleep were also assessed.ResultsOral pregabalin significantly prolonged the time to two-segment regression of sensory block, reaching 86.67±17.88 mins, the time required to regression of spinal block to L2, reaching 155.33± 34.71 mins, and the duration of motor block, reaching 138 ± 23.5 mins, with no effect on the onset of sensory or motor block (P = 0.60 and 0.62). It significantly decreased the VAS score 4 hrs, 6 hrs, and 12 hrs postoperatively, prolonged the duration of postoperative analgesia, reaching 392.00±47.23 mins, and decreased morphine consumption to 7.67±3.65 mg. It also improved the quality of sleep in the first night after surgery.ConclusionPreemptive oral pregabalin prolonged the time to the first request for postoperative analgesics and improved sleep in the first night after surgery.

The preemptive effects of oral pregabalin on perioperative pain management in lower limb orthopedic surgery: a systematic review and meta-analysis

“…Trials were defined as moderate quality if they did not meet the above criteria. Sixteen trials were graded as high quality [ 12 – 14 , 16 – 18 , 20 – 23 , 25 , 27 , 28 , 30 – 32 ], and five trials were graded as moderate quality [ 15 , 19 , 24 , 26 , 29 ]. The details of the quality assessment are displayed in Fig.…”

The combined analgesic effect of pregabalin and morphine in the treatment of pancreatic cancer pain, a retrospective study

“…Several studies have shown the analgesic efficacy of using pregabalin in perioperative setting. 21,22 However, the role of pregabalin in cancer-induced pain is controversial. In a study of patients with cancer-induced bone pain, pregabalin combining with palliative radiotherapy did not show additional benefit compared to patients receiving radiotherapy alone.…”

“…Several studies have shown the analgesic efficacy of using pregabalin in perioperative setting 21,22 . However, the role of pregabalin in cancer‐induced pain is controversial.…”

Preemptive Analgesia with a Second Dose of Pregabalin, Acetaminophen, Naproxen, and Dextromethorphan: A Comparative Clinical Trial in Major Surgeries

“…In a study conducted to evaluate the effect of oral pregabalin on the duration and quality of postoperative analgesia in spinal anesthesia, it was shown that oral pregabalin extended the duration of postoperative analgesia and reduced morphine intake. Moreover, it improved sleep quality during the first postoperative night (43). In another study aimed at investigating the effect of prophylactic use of oral pregabalin-acetaminophen-naproxen on pain control and morphine usage in patients who had undertaken laparotomy, patients in the PAN group (pregabalin 150 mg, acetaminophen 1 g, and naproxen 250 mg) experienced lower pain and the morphine use was also significantly lower than the control group (44).…”