&lt;p&gt;The accuracy assessment of presepsin (sCD14-ST) for mortality prediction in adult patients with sepsis and a head-to-head comparison to PCT: a meta-analysis&lt;/p&gt;

Zhu, Ying; Li, Xuehui; Guo, Peiyan; Chen, Yuhan; Li, Jiandong; Tao, Tianzhu

doi:10.2147/tcrm.s198735

Cited by 25 publications

(28 citation statements)

References 61 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A meta-analysis ( 30 ) including 23 studies with 3994 patients found that elevated PCT levels were associated with a higher risk for death. Nevertheless, a recently published study ( 31 ) also found that PCT was a promising biomarker for the prognosis of mortality in sepsis, with an AUROC of 0.81, which was higher than our results. This may be attributed to patient selection and PCT testing time.…”

Section: Discussioncontrasting

confidence: 96%

Predictive performance of critical illness scores and procalcitonin in sepsis caused by different gram-stain bacteria

Shi¹,

Zhang²

2021

Clinics

View full text Add to dashboard Cite

OBJECTIVES: To compare the early and late predictive values of several critical illness scores (CISs) and biomarkers in sepsis-3 patients with bloodstream infections (BSIs) and to identify the prognostic value of procalcitonin (PCT) for different gram-stain bacteria infections. METHODS: Patients with at least one positive blood culture within 24h of emergency department admission and with a final diagnosis of sepsis/septic shock were enrolled. CISs were calculated based on the first parameters on the day of admission. The receiver operating characteristics curve was used to analyze the predictive value of CISs and biomarkers for early and late mortality. RESULTS: Of 834 enrolled patients with sepsis-3, death occurred in 214 patients within 28 days and in 273 patients within 60 days. Compared with biomarkers, CISs showed a significantly higher area under the curve (AUC) in the prediction of early and late mortality ( p <0.01), especially for patients with GNB infection. The Sequential Organ Failure Assessment score showed a higher AUC for predicting early mortality than the Mortality in Emergency Department Sepsis score ( p =0.036). Compared with GNB infections, the AUC values of the PCT for gram-positive bacteria (GPB) infections were higher for predicting early or late mortality; PCT showed higher AUC than high-sensitivity C-reactive protein and white blood cells for predicting early mortality ( p <0.05). CONCLUSIONS: CISs were more advantageous in the assessment of early and late prognosis, especially for patients with GNB infections; however, for sepsis with GPB infection, PCT can be used for the prediction of early mortality.

show abstract

Section: Discussioncontrasting

confidence: 96%

Predictive performance of critical illness scores and procalcitonin in sepsis caused by different gram-stain bacteria

Shi¹,

Zhang²

2021

Clinics

View full text Add to dashboard Cite

show abstract

“…On the other hand, although CRP is widely used in the critical care setting and its value as a prognostic and predictor marker is proven in many diseases including sepsis, the levels of CRP in the current study could not predict the mortality in the studied septic patients. Such findings agreed with others who reported that the initial CRP values did not predict mortality in septic ICU patients [35,41].…”

Section: Discussionsupporting

confidence: 93%

“…On the other hand, no significant difference in CRP levels existed between the two subgroups. Such results agreed with the another study which demonstrated that the PCT and presepsin levels were good parameters for reflecting the severity of sepsis [21] On the contrary, Ulla et al reported no differences in the presepsin levels between the sepsis and septic shock groups, and Zhu et al showed no significant association between the level of PCT and the grade of sepsis [34,35].…”

Section: Discussionsupporting

confidence: 89%

Presepsin, Procalcitonin and C Reactive Protein as Diagnostic Biomarkers of Sepsis in Intensive Care Unit Patients

Shabrawy

Gawish

Elgabry

et al. 2021

Microbes and Infectious Diseases

View full text Add to dashboard Cite

Background: Sepsis is a global, life-threatening health priority. Blood culture is the gold standard of diagnosis of sepsis, however, it requires several days, which delays the diagnosis of the sepsis. Biomarkers could play a pivotal role in diagnosis, grading and predicting the outcome of sepsis. Objectives: To assess the potential role of C-reactive protein (CRP), procalcitonin (PCT) and presepsin for diagnosis, grading and predicting the prognosis of sepsis. Methods: The study included 28 patients diagnosed with sepsis, and 28 intensive care unit (ICU) patients presented by different presentations but with no sepsis. For patients with sepsis, APACHE II score was calculated, blood culture was done using BacT/Alert system, and Vitek 2 to identify bacterial isolates. For all subjects included in the study, quantitative measurement of CRP, PCT and presepsin were done using PA54 Specific Protein Analyzer, VIDAS ® immune-analyzer, and PATHFAST fully automated immunoassay analyzer, respectively. Results: APACHE II score positively correlated with PCT (p=0.026) and presepsin (p=0.034), but not CRP (p=0.291). Differences between cases and control group for the three biomarkers' levels were statistically significant (P value <0.001). For sepsis severity, there were significant increase in PCT and presepsin on admission (P value <0.001) among septic shock compared to sepsis cases. Procalcitonin was slightly superior than presepsin. Procalcitonin and presepsin showed statistically significant increase (P <0.001 & p=0.02 respectively) among died compared to survived subgroups. Conclusion: PCT and presepsin are reliable biomarkers for early diagnosis, grading and predicting of the prognosis of sepsis.

show abstract

“…Also in this regard, research and innovation would benefit from greater knowledge, skills and use of bioinformatics, epigenetics 9 and new biomarkers, such as presepsin. 10…”

Section: Challengesmentioning

confidence: 99%

<p>SEPSIS. Educational and Best Practice Frontiers. Beyond the Boundaries of Fatality, Enhancing Clinical Skills and Precision Medicine</p>

Trovato¹

2020

TCRM

View full text Add to dashboard Cite

Dissemination and exploitation of knowledge regarding affordable clinical skills and innovative precision medicine, two current topics in active development in medicine, may contribute to improve also sepsis management. Sepsis is a life-threatening organ dysfunction due to a dysregulated host response to infection. Sepsis is strongly related to all body organs or to systemic diseases and to the quality of the best-practice in use, which is particularly critical in surgical or intervention techniques. Trauma, surgical and mini-invasive procedures, vascular or endoscopic interventions, otolaryngology, obstetrics-gynecological and urological procedures, malnutrition, dental, skin, chronic liver, kidney and respiratory disease are frequently involved. Accordingly, apart from the clinical risk analysis and management of the process of care, the actual factors that may be easily neglected are the techniques used, the personal skills of the health professionals and the quality of the equipment. The quest for biomarkers consistent with the unmet needs of medical doctors and of their patient and the efforts for overcoming bacterial antibiotic resistances are currently the main foci of medical research. In addition, in this regard, research and innovation would benefit from greater knowledge, skills and use of bioinformatics and omics. The caveats related to in-silico approaches must be flagged: algorithms may equally warrant scientific innovations or hide the lack of them; a patient is more than a set of covariates. Epidemiology and prevention includes all the actions suitable for achieving an adequate hygiene and immunization of populations and for safer hospital policies and procedures during Patients' stays. In any subset, the most unresolved critical point in sepsis is a timely diagnosis. This is impaired by low degrees of suspicion for the possibility of emerging sepsis, by the shortage of use of the simplest microbiological testing but, equally or more, by the insufficient diffusion of non-invasive imaging skills suitable to detect and monitor the emerging sites and sources of infection. In primary care, in emergency facilities, in hospital wards and in intensive care units, inclusion of appropriate knowledge, skills, expertise and imaging equipment must be extended as much as possible. The low cost of UltraSound machines and of increasing bioinformatics literacy by e-learning, makes such investments affordable even in limited-resources contexts. Frontier educational and best practice intervention enhancing affordable clinical skills and innovative precision medicine may lead beyond the boundaries of fatal outcomes in sepsis.

show abstract

<p>The accuracy assessment of presepsin (sCD14-ST) for mortality prediction in adult patients with sepsis and a head-to-head comparison to PCT: a meta-analysis</p>

Cited by 25 publications

References 61 publications

Predictive performance of critical illness scores and procalcitonin in sepsis caused by different gram-stain bacteria

Predictive performance of critical illness scores and procalcitonin in sepsis caused by different gram-stain bacteria

Presepsin, Procalcitonin and C Reactive Protein as Diagnostic Biomarkers of Sepsis in Intensive Care Unit Patients

<p>SEPSIS. Educational and Best Practice Frontiers. Beyond the Boundaries of Fatality, Enhancing Clinical Skills and Precision Medicine</p>

Contact Info

Product

Resources

About