&lt;p&gt;Targeting cell cycle protein in gastric cancer with CDC20siRNA and anticancer drugs (doxorubicin and quercetin) co-loaded cationic PEGylated nanoniosomes&lt;/p&gt;

Hemati, Mahdie; Haghiralsadat, Fateme; Jafary, Fariba; Moosavizadeh, Seyedmohammad

doi:10.2147/ijn.s211844

Cited by 37 publications

(29 citation statements)

References 26 publications

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“…[168] Thermosensitive cationic liposomes that co-deliver anticancer drugs (doxorubicin or quercetin) and CDC20 siRNA have notable inhibitory effect on gastric cancer cells. [169] Temperature-responsive vectors are often used in conjunction with other stimulus, which are described in subsequent sections on multiple stimuli-responsive nanocarriers. Thermosensitive materials do have limitations.…”

Section: Temperature-responsive Nanocarriersmentioning

confidence: 99%

Recent Advances in Stimulus‐Responsive Nanocarriers for Gene Therapy

Cheng

et al. 2021

Advanced Science

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Gene therapy provides a promising strategy for curing monogenetic disorders and complex diseases. However, there are challenges associated with the use of viral delivery vectors. The advent of nanomedicine represents a quantum leap in the application of gene therapy. Recent advances in stimulus-responsive nonviral nanocarriers indicate that they are efficient delivery systems for loading and unloading of therapeutic nucleic acids. Some nanocarriers are responsive to cues derived from the internal environment, such as changes in pH, redox potential, enzyme activity, reactive oxygen species, adenosine triphosphate, and hypoxia. Others are responsive to external stimulations, including temperature gradients, light irradiation, ultrasonic energy, and magnetic field. Multiple stimuli-responsive strategies have also been investigated recently for experimental gene therapy.

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Section: Temperature-responsive Nanocarriersmentioning

confidence: 99%

Recent Advances in Stimulus‐Responsive Nanocarriers for Gene Therapy

Cheng

et al. 2021

Advanced Science

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“…For this aim, nanoliposomes were diluted with deionized water at a ratio of 1:1000 and then sonicated for 20 minutes in an ultrasonic agitator (E-Chrom Tech Co, Taiwan). Then, the obtained solution was deposited onto a mica sheet and observed by AFM (16).…”

Section: Atomic Force Microscopy (Afm)mentioning

confidence: 99%

“…About 500 µL of the nanoliposomes loaded LAEO were transferred into a 12 kDa cut-off dialysis tube and incubated in tube containing phosphate-buffered saline (PBS), as a medium, for 72 h at 37 °C and 42 °C (for cancer cells), and the pH values of 7.4 and 5.4 (tumor microenvironment) under gentle vibration. Then, the drug release rate was calculated by recording the optical absorbance of samples at a wavelength of 270 nm using a UV/VIS spectrophotometer (Beckman, DU 530, Switzerland) (16).…”

Section: In-vitro Release Pro Lementioning

confidence: 99%

Lavandula Angustifolia Essential Oil Loaded in Liposomal Nano-Carriers Regulate the HER2 and CASP3 Genes in MCF-7 and SK-BR-3 Cell-Lines

Mohammadpanah

Mojodi

Haghiralsadat

et al. 2020

Preprint

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Abstract Cancer drug delivery has recently focused on using novel carrier systems due to their high drug-loading capacity, release rate properties, and minimum side effects. Finding novel chemotherapeutic agents would be essential for the improvement of integrated treatment planning. In this study, the effect of constructed nano-liposomal particles of Lavandula angustifolia essential oil (LAEO) was evaluated on cell toxicity and the expression of HER-2 and Caspase-3 genes in two MCF-7 and SK-BR-3 cell lines. Our results showed a high entrapment efficiency (50 ± 3.34), and a low average size (68.3 ± 7.28 nm) of nano-liposomes under suitable conditions. The surface charge of particles was at a range of -2 to -4.5 mV. The release rate of nanoparticles was estimated to be 63.98% (37 °C; pH = 7) and 87.63% (42 °C; pH = 5) in MCF-7 and SK-BR-3 cell lines after 48 hours, respectively. The stability of nanoparticles without a great increase in particle sizes and spherical shape was observed using force atomic microscopy. The degree of cell growth in response to nanoliposomal LAEO was significantly decreased in comparison with free essential oil (p-value < 0.01) when assayed on both cell lines. The analysis of gene expression showed that the treatment of cancer cell lines with nanoliposomal LAEO significantly elevated the relative expression of the caspase-3 gene while reducing the expression of HER-2 (P < 0.05). Based on the obtained results, it seems that LAEO in the form of nanoparticles could have more efficiency on the growth inhibition of cancer cell lines in comparison with the free form of the essential oil. Further studies are required to assess the in vivo effects of LAEO nanoliposomes with refined formulations against various types of cancer (Fig. 1).

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“…A major limitation for the use of anthracyclines is cardiotoxicity [ 50 , 52 , 53 ]. To reduce the side effects, various biomolecular nanocarriers have been considered [ 30 , 43 , 44 , 45 , 46 , 54 , 55 ].…”

Section: Introductionmentioning

confidence: 99%

Cancer-Targeted Controlled Delivery of Chemotherapeutic Anthracycline Derivatives Using Apoferritin Nanocage Carriers

Kurzątkowska

Pazos

Herschkowitz

et al. 2021

IJMS

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The interactions of chemotherapeutic drugs with nanocage protein apoferritin (APO) are the key features in the effective encapsulation and release of highly toxic drugs in APO-based controlled drug delivery systems. The encapsulation enables mitigating the drugs’ side effects, collateral damage to healthy cells, and adverse immune reactions. Herein, the interactions of anthracycline drugs with APO were studied to assess the effect of drug lipophilicity on their encapsulation excess n and in vitro activity. Anthracycline drugs, including doxorubicin (DOX), epirubicin (EPI), daunorubicin (DAU), and idarubicin (IDA), with lipophilicity P from 0.8 to 15, were investigated. We have found that in addition to hydrogen-bonded supramolecular ensemble formation with n = 24, there are two other competing contributions that enable increasing n under strong polar interactions (APO(DOX)) or under strong hydrophobic interactions (APO(IDA) of the highest efficacy). The encapsulation/release processes were investigated using UV-Vis, fluorescence, circular dichroism, and FTIR spectroscopies. The in vitro cytotoxicity/growth inhibition tests and flow cytometry corroborate high apoptotic activity of APO(drugs) against targeted MDA-MB-231 adenocarcinoma and HeLa cells, and low activity against healthy MCF10A cells, demonstrating targeting ability of nanodrugs. A model for molecular interactions between anthracyclines and APO nanocarriers was developed, and the relationships derived compared with experimental results.

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<p>Targeting cell cycle protein in gastric cancer with CDC20siRNA and anticancer drugs (doxorubicin and quercetin) co-loaded cationic PEGylated nanoniosomes</p>

Cited by 37 publications

References 26 publications

Recent Advances in Stimulus‐Responsive Nanocarriers for Gene Therapy

Recent Advances in Stimulus‐Responsive Nanocarriers for Gene Therapy

Lavandula Angustifolia Essential Oil Loaded in Liposomal Nano-Carriers Regulate the HER2 and CASP3 Genes in MCF-7 and SK-BR-3 Cell-Lines

Cancer-Targeted Controlled Delivery of Chemotherapeutic Anthracycline Derivatives Using Apoferritin Nanocage Carriers

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