<p>Targeted Therapy for Hepatocellular Carcinoma: Co-Delivery of Sorafenib and Curcumin Using Lactosylated pH-Responsive Nanoparticles</p>

Abstract

Purpose: Hepatocellular carcinoma (HCC) is a leading cancer worldwide. In the present investigation, sorafenib (SFN) and curcumin (CCM) were co-delivered using pH-sensitive lactosylated nanoparticles (LAC-NPs) for targeted HCC treatment. Methods: pH-responsive lactosylated materials were synthesized. SFN and CCM codelivered, pH-responsive lactosylated nanoparticles (LAC-SFN/CCM-NPs) were selfassembled by using the nanoprecipitation technique. The nanoparticles were characterized in terms of particle size, charge and drug release profile. The anti-cancer effects of the nanoparticles were evaluated in human hepatic carcinoma cells (HepG2) cells and HCC tumor xenograft models. Results: LAC-SFN/CCM-NPs are spherical particles with light coats on the surface. The size and zeta potential of LAC-SFN/CCM-NPs were 115.5 ± 3.6 nm and −34.6 ± 2.4, respectively. The drug release of LAC-SFN/CCM-NPs in pH 5.5 was more efficient than in pH 7.4. LAC-SFN/CCM-NPs group exhibited the smallest tumor volume (239 ± 14 mm 3 ), and the inhibition rate of LAC-SFN/CCM-NPs was 77.4%. Conclusion: In summary, LAC-SFN/CCM-NPs was proved to be a promising system for targeted HCC therapy.

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

“…In light of this, a number of research have been devoted on the solubility enhancements or encapsulation of curcumin targeted drug delivery platforms for biomedical applications ( Deljoo et al, 2019 ; Zare et al, 2019a ; Zare et al, 2019b ). For instance, a number of nanoscale carriers (e.g., micelles, liposomes, polymeric nanocarriers, lipid nanoparticles, and carbon nanotubes) have been developed to encapsulate hydrophobic active compounds such as curcumin ( Bian and Guo, 2020 ; Li et al, 2020b ; Hu et al, 2020 ; Varshosaz et al, 2020 ; Zhao et al, 2020 ). Such platforms enhanced the therapeutic efficacy of curcumin along with prolonged delivery.…”

Albumin-Albumin/Lactosylated Core-Shell Nanoparticles: Therapy to Treat Hepatocellular Carcinoma for Controlled Delivery of Doxorubicin

“…This can contribute to a higher level of tumor cell cytotoxicity in an in vivo system. All NPs presented PDI values <0.2, considered to have a homogeneous narrow distribution [ 28 ]. Control NPs presented zeta potentials of −32.0 ± 0.5 mV and −31.0 ± 0.5 mV, while lactosylated NPs showed −28.0 ± 0.1 mV and −26.0 ± 0.2 for LC and HC, respectively.…”

“…Therefore, lactosylation of BSA it would not have a high influence on the Z potential of NPs. On the other hand, it is important to highlight that negative values indicate that clearance by the reticuloendothelial system (RES) could be reduced due to the low absorption of plasma proteins on the surface of the nanoparticles [ 28 ].…”

“…In Figure 6 B,C the results showed that dox loaded in nanoparticles with BSALac shell (LC tBSA/BSALac NPs and HC tBSA/BSALac NPs) inhibited the viability and proliferation of HepG2 cells at low concentrations. The slightly more cytotoxicity of nanoparticles with BSALac shell compared with nanoparticles without BSALac shell, are the evidence of the targeted ability of lactose to HepG2 cells improved cell uptake, therefore, the cytotoxic effect [ 28 ]. This effect was previously reported by Quan et al, 2015 [ 48 ] where the cellular uptake study showed the internalization process for lactosylated NPs was energy-consuming and predominated by clathrin-mediated pathway and suggested that this nanoparticle transported the drug into hepatoma cells more effectively than non-lactosylated NPs.…”

Chemo-immune synergetic therapy of esophageal carcinoma: trastuzumab modified, cisplatin and fluorouracil co-delivered lipid–polymer hybrid nanoparticles

“…Cell uptake extent of LPHNs was measured by encapsulating C-6 as an indicator (Bian & Guo, 2020 ). C-6 encapsulated TAB-CIS/5-FU LPHNs and CIS/5-FU LPHNs were added to BE-3 cells and incubated for 1 h. Cells were then washed with PBS (1 mL) and photographed by fluorescence microscopy.…”