<p>Survival, Prevalence, Progression and Repair of Abdominal Aortic Aneurysms: Results from Three Randomised Controlled Screening Trials Over Three Decades</p>

Abstract

The prevalence and mortality of abdominal aortic aneurysms (AAA) has been reported to decline. The aim of this study is to compare survival, prevalence, and repair rate of AAA in Denmark in the 1990s, the 2000s and the 2010sand to examine any change in factors known to influence the prevalence. Methods: Baseline status and up to 5-year outcomes of 34,079 general population men aged 65-74 were obtained from three RCTs;

Ultra-low-dose non-contrast CT and CT angiography can be used interchangeably for assessing maximal abdominal aortic diameter

“…Revising the article; 6. Final approval; Jens Borgbjerg [1,3,4,5,6], Heidi S. Christensen [1,3,4,5,6], Rozh Al-Mashhadi [1,2,3,4,5,6], Martin Bøgsted [1,4,5,6], Jens B Froekjaer [2,3,4,5,6], Lise Medrud [2,4,5,6], Nis Elbrønd Larsen [2,3,4,5,6], Jes S. Lindholt [1,3,4,5,6]…”

“…Population-based systematic screening programs following this algorithm are cost-effective in reducing mortality and are recommended in guidelines. 1,2,3 However, the evidence for systematic screening has existed for decades, so the likelihood of population-based screening programs being implemented in countries without current programs established is low. Here opportunistic screening could be the optimal alternative.…”

Diseases of the Aorta and Kidney Disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

“…Traditional risk factors for AAA include age, smoking, hypertension, and family history, with a higher prevalence in men across all ages. 6 The disease is characterized by infiltration of inflammatory cells including macrophages and lymphocytes into the aortic wall, and associated atherosclerotic processes may also be present. In addition, there is progressive loss of vascular smooth muscle cells (VSMCs) from the aortic wall and degradation of the extracellular matrix due to the production of matrix-degrading enzymes linked to inflammatory cell infiltration and VSMC phenotype change ( Figure 3 ).…”

The Global and Regional Prevalence of Abdominal Aortic Aneurysms: A Systematic Review and Modeling Analysis

“… 7 However, in many low-income and middle-income countries (LMICs), rising prevalence of smoking, hypertension, harmful use of alcohol, and many cardiovascular risk factors are continually reported, suggesting a likely increasing burden of AAA, particularly with a relatively poor overall public health response. 6 , 7 …”

“…[2][3][4][5] Decreasing prevalence of tobacco smoking, as observed in some high-income countries (HICs), may have driven this decline. 6 In addition to reduced exposure to risks, the use of antihypertensives and cardioprotective medications in many HICs may have also contributed to this decline. 7 However, in many low-income and middle-income countries (LMICs), rising prevalence of smoking, hypertension, harmful use of alcohol, and many cardiovascular risk factors are continually reported, suggesting a likely increasing burden of AAA, particularly with a relatively poor overall public health response.…”