<p>Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy</p>

Abstract

PurposeTo evaluate macular vasculature in diabetic retinopathy (DR) with optical coherence tomography angiography (OCTA) and to correlate vessel density (VD) with retinal sensitivity (RS) as a way to assess structural and functional findings in DR.DesignProspective observational cross-sectional study.MethodsDiabetic patients with DR but no clinically significant diabetic macular edema (DME) and healthy subjects were included in this study. All of them underwent comprehensive ophthalmic examination, best corrected visual acuity (BCVA), OCTA with RS-3000 Advance AngioScan (Nidek, Gamagori, Japan) and microperimetry with MP-3 (Nidek, Gamagori, Japan). Retinal vascular density measured by OCT angiography in 9 areas was correlated with RS in the same 9 areas by Spearman correlation.ResultsIn this study, 50 subjects were enrolled: 25 eyes of diabetic patients with DR and 25 eyes of non-diabetic subjects. Diabetic patients mean age was 51.88±13.62 years; non-diabetic subjects were 43.48±13.42 years. The BCVA was 20/25 in the diabetic group and 20/20 in the non-diabetic group. Mean RS was decreased in the DR group (27.68±2.71 dB) compared to the non-diabetic group (31.68±1.46 dB) (p<0.05) and in the 9 studied areas (p<0.05). Mean VD was decreased in the DR group compared to non-diabetics (p<0.05) and in 7 of the 9 areas (except temporal superior and inferior squares) (p<0.05). Correlations by areas between VD and RS were assessed, we found moderate correlation in the area temporal to the fovea (r=0.501, p=0.01) in the DR group but not in the non-diabetic subjects. There were no other statistical significant correlations with this pattern.ConclusionDR without DME results in a retinal VD decreased that might be the cause of a reduction of RS in one of the studied areas. Microangiopathic changes are correlated with microperimetry sensitivity drop in the temporal to the fovea grid but not in the other studied grids.

Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes

“…Therefore, we categorized all RS locations into four groups, based on FD and leakage. At points where leakage was low, RS decreased when FD decreased (group A vs. group B; P < 0.0001, P < 0.007 and P < 0.004 in TCP, SCP and DCP, respectively), as previously reported 9 , 16 . However, contrary to expectations, at points with high leakage, FD only significantly affected RS in the DCP (group C vs. group D; P < 0.0004).…”

“…Fluorescein angiography (FA) studies have demonstrated significant reduction in RS in non-perfused areas 5 , 6 , suggesting that perfusion status affects RS. Unlike FA, optical coherence tomography angiography (OCTA) allows quantification of flow density (FD) 7 : several studies have shown that FD is associated with RS in DR 8 , 9 .…”

Multiscale Correlation of Microvascular Changes on Optical Coherence Tomography Angiography With Retinal Sensitivity in Diabetic Retinopathy

“…scale and in perifoveal regions. [38][39][40][41] This finding was true for all three retinal vasculature slabs tested. We believe, however, that this is the first article to demonstrate a quantitative, pointwise structure-function relationship between retinal sensitivity and vessel density in DR.…”

Measuring of retina function using microperimetry in diabetic retinopathy

“…The University Hospital of La Candelaria Department of Ophthalmology in Tenerife (Spain) performed a study related to structure-function correlation using optical coherence tomography (OCT) angiography and microperimetry in diabetic retinopathy using the MP-3 system (Nidek, Aichi, Japan) in the year 2019 [2].…”