&lt;p&gt;Starch-mediated synthesis of mono- and bimetallic silver/gold nanoparticles as antimicrobial and anticancer agents&lt;/p&gt;

Lomelí-Marroquín, Diana; Medina-Cruz, David; Nieto-Argüello, Alfonso; Vernet-Crua, Ada; Chen, Junjiang; Torres–Castro, Alejandro; Webster, Thomas J.; Cholula-Díaz, Jorge L.

doi:10.2147/ijn.s192757

Cited by 104 publications

(61 citation statements)

References 59 publications

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“…15,18 Especially, low drug-resistant problems have generated using AuNPsrelated nanomedicines. 19 However, most of these AuNPs (5-100 nm) related medicines are still difficult to be cleaned from the body because of their large sizes. 20 The remaining gold is still a concern for safe medication.…”

Section: Introductionmentioning

confidence: 99%

<p>Ultra-Small Lysozyme-Protected Gold Nanoclusters as Nanomedicines Inducing Osteogenic Differentiation</p>

Li¹,

Zhuang²,

Tao³

et al. 2020

IJN

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Ultra-small gold nanoclusters (AuNCs), as emerging fluorescent nanomaterials with excellent biocompatibility, have been widely investigated for in vivo biomedical applications. However, their effects in guiding osteogenic differentiation have not been investigated, which are important for osteoporosis therapy and bone regeneration. Herein, for the first time, lysozymeprotected AuNCs (Lys-AuNCs) are used to stimulate osteogenic differentiation, which have the potential for the treatment of bone disease. Methods: Proliferation of MC3T3E-1 is important for osteogenic differentiation. First, the proliferation rate of MC3T3E-1 was studied by Cell Counting Kit-8 (CCK8) assays. Signaling pathways of PI3K/Akt play central roles in controlling proliferation throughout the body. The expression of PI3K/Akt was investigated in the presence of lysozyme, and lysozyme-protected AuNCs (Lys-AuNCs) by Western blot (WB) and intracellular cell imaging to evacuate the osteogenic differentiation mechanisms. Moreover, the formation of osteoclasts (OC) plays a negative role in the differentiation of osteoblasts. Nuclear factor κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) signaling pathways are used to understand the negative influence of the osteogenic differentiation by the investigation of Raw 264.7 cell line. Raw 264.7 (murine macrophage-like) cells and NIH/3T3 (mouse fibroblast) cells were treated with tyloxapol, and the cell viability was assessed. Raw 264.7 cells have also been used for in vitro studies, on understanding the osteoclast formation and function. The induced osteoclasts were identified by TRAP confocal fluorescence imaging. These key factors in osteoclast formation, such as (NFATc-1, c-Fos, V-ATPase-2 and CTSK), were investigated by Western blot. Results: Based on the above investigation, Lys-AuNCs were found to promote osteogenic differentiation and decrease osteoclast activity. It is noteworthy that the lysozyme (protected template), AuNPs, or the mixture of Lysozyme and AuNPs have negligible effects on osteoblastic differentiation compared to Lys-AuNCs. Conclusion: This study opens up a novel avenue to develop a new gold nanomaterial for promoting osteogenic differentiation. The possibility of using AuNCs as nanomedicines for the treatment of osteoporosis can be expected.

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Section: Introductionmentioning

confidence: 99%

<p>Ultra-Small Lysozyme-Protected Gold Nanoclusters as Nanomedicines Inducing Osteogenic Differentiation</p>

Li¹,

Zhuang²,

Tao³

et al. 2020

IJN

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“…164 As a consequence, great efforts have been made to establish green nanotechnology approaches in the field: from the use of bacteria or fungi as raw materials, to the employment of plant extracts or waste materials. 165,166 Therefore, these green NMs have been used in different applications in the biomedical field. 98,167 In terms of electroconductive NMs, not many examples have been recently released to literature, however, efforts toward this end have shown that the use of green practices can allow for a sustainable production of such NMs and their successful application within tissue engineering and regenerative medicine.…”

Section: Concluding Remarks and Future Perspectivementioning

confidence: 99%

Electroconductive Nanobiomaterials for Tissue Engineering and Regenerative Medicine

et al. 2020

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Regenerative medicine aims to engineer tissue constructs that can recapitulate the functional and structural properties of native organs. Most novel regenerative therapies are based on the recreation of a three-dimensional environment that can provide essential guidance for cell organization, survival, and function, which leads to adequate tissue growth. The primary motivation in the use of conductive nanomaterials in tissue engineering has been to develop biomimetic scaffolds to recapitulate the electrical properties of the natural extracellular matrix, something often overlooked in numerous tissue engineering materials to date. In this review article, we focus on the use of electroconductive nanobiomaterials for different biomedical applications, particularly, very recent advancements for cardiovascular, neural, bone, and muscle tissue regeneration. Moreover, this review highlights how electroconductive nanobiomaterials can facilitate cell to cell crosstalk (i.e., for cell growth, migration, proliferation, and differentiation) in different tissues. Thoughts on what the field needs for future growth are also provided.

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“…Lomelí-Marroquín D. et al (2019) achieved the synthesis of bimetallic silver/gold nanoparticles, with the advantages of an increased biocompatibility, usually associated with AuNPs, and of a decreased toxicity of silver nanoparticles (AgNPs) [14]. The product exhibited a dose-dependent anticancer effect on melanoma cells in vitro [14].…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Nanosystems for Improved Targeted Therapies in Melanoma

Beiu

Giurcăneanu

Grumezescu

et al. 2020

JCM

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Melanoma is one of the most aggressive forms of skin cancer, with limited therapeutic options. Since its incidence has been rapidly rising in recent years, the study of new targeted therapeutic strategies has increased. The implication of nanoscience in the development of alternative targeted therapies for melanoma has multiple benefits and could significantly improve the outcome of melanoma patients. In this paper, we review the most recent progress in the field of targeted therapies, emphasizing the impact of nanoscale materials on the targeting and controlled release of anti-tumor drugs. The applications of nanomedicine in the management of melanoma are extensive and refer to sentinel lymph node mapping, chemotherapy, and RNA interference; each of these applications harboring the potential to develop efficient and personalized diagnostic techniques and therapies. Further research, especially in clinical trials, is needed to establish whether fighting melanoma on the nanoscale level represents the key to reaching a critical inflection point in mankind’s battle with metastatic melanoma.

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<p>Starch-mediated synthesis of mono- and bimetallic silver/gold nanoparticles as antimicrobial and anticancer agents</p>

Cited by 104 publications

References 59 publications

<p>Ultra-Small Lysozyme-Protected Gold Nanoclusters as Nanomedicines Inducing Osteogenic Differentiation</p>

<p>Ultra-Small Lysozyme-Protected Gold Nanoclusters as Nanomedicines Inducing Osteogenic Differentiation</p>

Electroconductive Nanobiomaterials for Tissue Engineering and Regenerative Medicine

Nanosystems for Improved Targeted Therapies in Melanoma

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