&lt;p&gt;Sleep and Methylation of Estrogen Receptor Genes, &lt;em&gt;ESR1&lt;/em&gt; and &lt;em&gt;GPER&lt;/em&gt;, in Healthy Middle-Aged and Older Women: Findings from the Women 40+ Healthy Aging Study&lt;/p&gt;

Gardini, Elena; Fiacco, Serena; Mernone, Laura; Ehlert, Ulrike

doi:10.2147/nss.s256102

Cited by 6 publications

(4 citation statements)

References 83 publications

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“…Interestingly, in our selected cases, the same supplement was involved (Cimifemin—6.5 mg of dry extract—Ze 450), in case CR1 , 2. This product was used in retrospective observational studies 44 , 45 without particular adverse effects. As both reports took place in Switzerland at close dates in 2016/17, it can be reasonably assumed that a particular batch had possibly been incriminated.…”

Section: Resultsmentioning

confidence: 99%

Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database

Pochet

Lechon

Lescrainier³

et al. 2022

Sci Rep

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Cancer patients could combine herbal treatments with their chemotherapy. We consulted VigiBase, a WHO database of individual case safety reports (ICSRs) which archives reports of suspected Adverse Drug Reactions (ADRs) when herbal products are used in conjunction with anti-cancer treatment. We focused on the possible interactions between antineoplastic (L01 ATC class) or hormone antagonists (L02B ATC class) with 10 commonly used herbs (pineapple, green tea, cannabis, black cohosh, turmeric, echinacea, St John’s wort, milk thistle and ginger) to compare ADRs described in ICSRs with the literature. A total of 1057 ICSRs were extracted from the database but only 134 were complete enough (or did not concern too many therapeutic lines) to keep them for analysis. Finally, 51 rationalizable ICSRs could be explained, which led us to propose a pharmacokinetic or pharmacodynamic interaction mechanism. Reports concerned more frequently women and half of the rationalizable ICSRs involved Viscum album and Silybum marianum. 5% of the ADRs described could have been avoided if clinicians had had access to the published information. It is also important to note that in 8% of the cases, the ADRs observed were life threatening. Phytovigilance should thus be considered more by health care professionals to best treat cancer patients and for better integrative care.

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Section: Resultsmentioning

confidence: 99%

Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database

Pochet

Lechon

Lescrainier³

et al. 2022

Sci Rep

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“…Moreover, the association between sleep deprivation and changes in the epigenome has been investigated [ 46 ]. An association has been identified between increased estrogen receptor methylation and sleep problems, suggesting that ESR1 methylation may be linked to vasomotor symptoms and consequently contribute to increased sleep problems in healthy middle-aged and older women [ 47 ]. This association could be further analyzed in further studies, in addition to its potential connection to CVD.…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of DNA Methylation Levels and Sleep in Relation to Hot Flashes: A Cross-Sectional Study

Ozcivit Erkan,

Seyisoglu,

Benbir Senel

et al. 2024

JCM

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Objectives: We aimed to evaluate the DNA methylation levels in perimenopausal and postmenopausal women, measured through Long Interspersed Element-1 (LINE-1) and Alu, and the sleep parameters in relation to the presence of hot flashes (HFs). Methods: This cross-sectional study included 30 peri- or postmenopausal women aged between 45 and 55. The menopausal status was determined according to STRAW + 10 criteria and all participants had a low cardiovascular disease (CVD) risk profile determined by Framingham risk score. The sample was divided into two groups based on the presence or absence of HFs documented in their medical history during their initial visit: Group 1 (n = 15) with HFs present and Group 2 (n = 15) with HFs absent. The patients had polysomnography test and HFs were recorded both by sternal skin conductance and self-report overnight. Genomic DNA was extracted from the women’s blood and methylation status was analyzed by fluorescence-based real-time quantitative PCR. The quantified value of DNA methylation of a target gene was normalized by β-actin. The primary outcome was the variation in methylation levels of LINE-1 and Alu and sleep parameters according to the presence of HFs. Results: LINE-1 and Alu methylation levels were higher in Group 1 (HFs present), although statistically non-significant. LINE-1 methylation levels were negatively correlated with age. Sleep efficiency was statistically significantly lower for women in Group 1 (HFs present) (74.66% ± 11.16% vs. 82.63% ± 7.31%; p = 0.03). The ratio of duration of awakening to total sleep time was statistically significantly higher in Group 1 (HFs present) (22.38% ± 9.99% vs. 15.07% ± 6.93, p = 0.03). Objectively recorded hot flashes were significantly higher in Group 1 (4.00 ± 3.21 vs. 1.47 ± 1.46, p = 0.03). None of the cases in Group 2 self-reported HF despite objectively recorded HFs during the polysomnography. The rate of hot flash associated with awakening was 41.4% in the whole sample. Conclusions: Women with a history of hot flashes exhibited lower sleep efficiency and higher awakening rates. Although a history of experiencing hot flashes was associated with higher LINE-1 and Alu methylation levels, no statistical significance was found. Further studies are needed to clarify this association. This study was funded by the Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa. Project number: TTU-2021-35629.

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“…The presence of sex hormone receptors in most tissues is relatively constant across the lifespan, although levels and functioning for some receptors can vary across the menstrual cycle ( Zelenko et al, 2012 ; Kruger et al, 2023 ) and during aging ( Gardini et al, 2020 ; Oveisgharan et al, 2023 ). Some of such changes can be cell and tissue-specific and are potentially due to methylation of the receptor genes ( Penolazzi et al, 2004 ; Tsuboi et al, 2017 ).…”

Section: Analysis Of Sex Differences In Risk For Msk Conditions and D...mentioning

confidence: 99%

Sex differences in musculoskeletal injury and disease risks across the lifespan: Are there unique subsets of females at higher risk than males for these conditions at distinct stages of the life cycle?

Hart

2023

Front. Physiol.

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Sex differences have been reported for diseases of the musculoskeletal system (MSK) as well as the risk for injuries to tissues of the MSK system. For females, some of these occur prior to the onset of puberty, following the onset of puberty, and following the onset of menopause. Therefore, they can occur across the lifespan. While some conditions are related to immune dysfunction, others are associated with specific tissues of the MSK more directly. Based on this life spectrum of sex differences in both risk for injury and onset of diseases, a role for sex hormones in the initiation and progression of this risk is somewhat variable. Sex hormone receptor expression and functioning can also vary with life events such as the menstrual cycle in females, with different tissues being affected. Furthermore, some sex hormone receptors can affect gene expression independent of sex hormones and some transitional events such as puberty are accompanied by epigenetic alterations that can further lead to sex differences in MSK gene regulation. Some of the sex differences in injury risk and the post-menopausal disease risk may be “imprinted” in the genomes of females and males during development and sex hormones and their consequences only modulators of such risks later in life as the sex hormone milieu changes. The purpose of this review is to discuss some of the relevant conditions associated with sex differences in risks for loss of MSK tissue integrity across the lifespan, and further discuss several of the implications of their variable relationship with sex hormones, their receptors and life events.

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<p>Sleep and Methylation of Estrogen Receptor Genes, <em>ESR1</em> and <em>GPER</em>, in Healthy Middle-Aged and Older Women: Findings from the Women 40+ Healthy Aging Study</p>

Cited by 6 publications

References 83 publications

Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database

Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database

An Evaluation of DNA Methylation Levels and Sleep in Relation to Hot Flashes: A Cross-Sectional Study

Sex differences in musculoskeletal injury and disease risks across the lifespan: Are there unique subsets of females at higher risk than males for these conditions at distinct stages of the life cycle?

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