&lt;p&gt;Significant prognostic values of aquaporin mRNA expression in breast cancer&lt;/p&gt;

Zhu, Lizhe; Ma, Nan; Wang, Bin; Wang, Lei; Zhou, Can; Yu, Yan; He, Jing; Ren, Yu

doi:10.2147/cmar.s193396

Cited by 42 publications

(31 citation statements)

References 44 publications

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“…Based on the present study, five of the eight genes in the signature had been previously recognized to participate in TNBC pathogenesis, immune microenvironment, progression and malignant transformation, which were interleukin-1 receptor-like 2, carbonic anhydrase 3, phosphodiesterase 1B, secreted Ly-6/uPAR-related protein and aquaporin 7 (60)(61)(62)(63). These five genes showed marked correlation with the prognosis and survival of patients.…”

Section: Discussionmentioning

confidence: 64%

Identification of a prognosis‑associated signature associated with energy metabolism in triple‑negative breast cancer

et al. 2020

Oncol Rep

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At present, a large number of exciting results have been found regarding energy metabolism within the triple-negative breast cancer (TNBC) field. Apart from aerobic glycolysis, a number of other catabolic pathways have also been demonstrated to participate in energy generation. However, the prognostic value of energy metabolism for TNBC currently remains unclear. In the present study, the association between gene expression profiles of energy metabolism and outcomes in patients with TNBC was examined using datasets obtained from the Gene Expression Omnibus and The Cancer Genome Atlas. In total, four robust TNBC subtypes were identified on the basis of negative matrix factorization clustering and gene expression patterns, which exhibited distinct immunological, molecular and prognostic (disease-free survival) features. The differentially expressed genes were subsequently identified from the subgroup that demonstrated the poorest prognosis compared with the remaining 3 subgroups, where their biological functions were assessed further by means of gene ontology enrichment analysis. Any signatures found to be associated with energy metabolism were then established using the Cox proportional hazards model to assess patient prognosis. According to results of Kaplan-Meier analysis, the constructed signature consisting of eight genes that were associated with energy metabolism distinguished patient outcomes into low-and high-risk groups. In addition, this signature, which was found to be markedly associated with the clinical characteristics of the patients, served as an independent factor in predicting TNBC patient prognosis. According to gene set enrichment analysis, the gene sets related to the high-risk group participated in the MAPK signal transduction pathway, focal adhesion and extracellular matrix receptor interaction, whilst those related to the low-risk group were revealed to be mainly associated with mismatch repair and propanoate metabolism. Findings from the present study shed new light on the role of energy metabolism within TNBC, where the eight-gene signature associated with energy metabolism constructed can be utilized as a new prognostic marker for predicting survival in patients with TNBC.

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Section: Discussionmentioning

confidence: 64%

Identification of a prognosis‑associated signature associated with energy metabolism in triple‑negative breast cancer

et al. 2020

Oncol Rep

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“…Mandinka reports AQP2 is independent of ovarian cancer 27 . In contrast, Zhu et al report AQP2 predicts a favorable prognosis in breast cancer 28 . In this paper, we find AQP2 is decreased in tumor tissue; however, AQP2 cannot affect the staging and prognosis in RCC.…”

Section: Discussionmentioning

confidence: 86%

Differential expression of epithelial sodium channels in human RCC associated with the prognosis and tumor stage: Evidence from integrate analysis

et al. 2020

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Background: Epithelial sodium channels are disputed in renal cell carcinoma, but its functions and effects on clinical outcomes are not well understood. Materials and Methods: IHC and PT-PCR were used to detect ENaCα, β, γ, AVPR2, AQP2, and MR expression in the primary tumor and peritumoral tissues. GEPIA online tool was used to analyze the relationship between epithelial sodium channels and clinical-pathological characteristics. Tumor IMmune Estimation Resource online tool was used to investigate the immune profile relevant to epithelial sodium channels expression. Results: Quantitative RT-PCR analysis revealed that ENaCα, β, γ, AQP2, and AVPR2 mRNA were decreased in the RCC, but there was no difference in MR mRNA expression between kidney and RCC ( p =0.238). The IHC analyses showed that the intensely positive staining of ENaCα, β, γ, AVPR2, and AQP in the renal tubular and the attenuated in the RCCs. MR displayed moderate staining in both RCC and normal tissue. With the promotion of staging, the expression of AQP2, AVPR2, and MR reduced gradually and predicted a better prognosis. Although ENaCα, β, and γ were unable to associate with staging, we still observed a high expression of ENaCβ and γ displayed a poorer prognosis of RCC. Conclusions: ENaCs shows an oncogene profile in RCC, drugs targeting epithelial sodium channel should be a possible therapeutic way to treat RCC. AVPR2 and MR exhibit an encouraging immunomodulatory function; patients with low expression of AVPR2 and MR may obtain more benefit from immunotherapy.

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“…AQP7 has been identified as possible major route of arsenite uptake into cells in humans [22]. Subsequently in several real-world cohorts, increased AQP7 mRNA expression demonstrated a significant association with advanced tumor grade, stage, and lymphatic metastasis events, as well as poor prognosis in breast [23] and liver [24] cancers.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value and immune infiltration of novel signatures in clear cell renal cell carcinoma microenvironment

Wang

et al. 2019

Aging

172

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Growing evidence has highlighted the immune response as an important feature of carcinogenesis and therapeutic efficacy in clear cell renal cell carcinoma (ccRCC). This study categorized ccRCC cases into high and low score groups based on their immune/stromal scores generated by the ESTIMATE algorithm, and identified an association between these scores and prognosis. Differentially expressed tumor environment (TME)-related genes extracted from common upregulated components in immune and stromal scores were described using functional annotations and protein–protein interaction (PPI) networks. Most PPIs were selected for further prognostic investigation. Many additional previously neglected signatures, including AGPAT9, AQP7, HMGCS2, KLF15, MLXIPL, PPARGC1A, exhibited significant prognostic potential. In addition, multivariate Cox analysis indicated that MIXIPL and PPARGC1A were the most significant prognostic signatures, and were closely related to immune infiltration in TCGA cohort. External prognostic validation of MIXIPL and PPARGC1A was undertaken in 380 ccRCC cases from a real-world cohort. These findings indicate the relevance of monitoring and manipulation of the microenvironment for ccRCC prognosis and precision immunotherapy.

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<p>Significant prognostic values of aquaporin mRNA expression in breast cancer</p>

Cited by 42 publications

References 44 publications

Identification of a prognosis‑associated signature associated with energy metabolism in triple‑negative breast cancer

Identification of a prognosis‑associated signature associated with energy metabolism in triple‑negative breast cancer

Differential expression of epithelial sodium channels in human RCC associated with the prognosis and tumor stage: Evidence from integrate analysis

Prognostic value and immune infiltration of novel signatures in clear cell renal cell carcinoma microenvironment

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