&lt;p&gt;Self-Renewal Signalling Pathway Inhibitors: Perspectives on Therapeutic Approaches for Cancer Stem Cells&lt;/p&gt;

Zhu, Qi; Shen, Yingying; Chen, Xiguang; He, Jun; Liu, Jianghua; Zu, Xuyu

doi:10.2147/ott.s224465

Cited by 24 publications

(22 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…miRNAs also through several signaling pathways can regulate the stemness features and tumorigenesis of BCSCs. Inhibition of key signaling pathways with small molecule inhibitors, nanoparticles, herbal medicine, and genetic modifications might be effective therapeutic approaches for targeting BCSCs [ 31 , 85 , 170 , 171 ].…”

Section: Discussionmentioning

confidence: 99%

Signaling pathways governing breast cancer stem cells behavior

Song¹,

Farzaneh

2021

Stem Cell Res Ther

View full text Add to dashboard Cite

Breast cancer is the second common cancer and the leading cause of malignancy among females overall. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that play a critical role in the metastasis of breast cancer to other organs in the body. BCSCs have both self-renewal and differentiation capacities, which are thought to contribute to the aggressiveness of metastatic lesions. Therefore, targeting BCSCs can be a suitable approach for the treatment and metastasis of breast cancer. Growing evidence has indicated that the Wnt, NFκB, Notch, BMP2, STAT3, and hedgehog (Hh) signaling pathways govern epithelial-to-mesenchymal transition (EMT) activation, growth, and tumorigenesis of BCSCs in the primary regions. miRNAs as the central regulatory molecules also play critical roles in BCSC self-renewal, metastasis, and drug resistance. Hence, targeting these pathways might be a novel therapeutic approach for breast cancer diagnosis and therapy. This review discusses known signaling mechanisms involved in the stimulation or prevention of BCSC self-renewal, metastasis, and tumorigenesis.

show abstract

Section: Discussionmentioning

confidence: 99%

Signaling pathways governing breast cancer stem cells behavior

Song¹,

Farzaneh

2021

Stem Cell Res Ther

View full text Add to dashboard Cite

show abstract

“…The poor survival and prognosis of individuals with cancer are often due to the presence of cancer stem cells (CSCs) [ 29 ]. CSCs are inherently resistant to radio- and chemotherapy [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs

Wójtowicz

Sterzyńska

Świerczewska

et al. 2021

IJMS

View full text Add to dashboard Cite

Our goal was to examine the anticancer effects of piperine against the resistant human ovarian cancer cells and to explore the molecular mechanisms responsible for its anticancer effects. Our study used drug-sensitive ovarian cancer cell line W1 and its sublines resistant to paclitaxel (PAC) and topotecan (TOP). We analyzed the cytotoxic effect of piperine and cytostatic drugs using an MTT assay. The impact of piperine on protein expression was determined by immunofluorescence and Western blot. We also examined its effect on cell proliferation and migration. We noticed a different level of piperine resistance between cell lines. Piperine increases the cytotoxic effect of PAC and TOP in drug-resistant cells. We observed an increase in PTPRK expression correlated with decreased pTYR level after piperine treatment and downregulation of P-gp and BCRP expression. We also noted a decrease in COL3A1 and TGFBI expression in investigated cell lines and increased COL3A1 expression in media from W1PR2 cells. The expression of Ki67 protein and cell proliferation rate decreased after piperine treatment. Piperine markedly inhibited W1TR cell migration. Piperine can be considered a potential anticancer agent that can increase chemotherapy effectiveness in cancer patients.

show abstract

“…Cancer cells inappropriately maintain self-renewal pathways similar to those found in stem cells (SCs), allowing indefinite proliferation, and understanding how these self-renewal pathways are maintained in cancer has therapeutic implications. Cancer stem cells (CSCs) are found in many malignant diseases and are associated with poor survival (Zhu et al, 2020 ). CSCs tend to remain quiescent, thereby conferring protection from therapies which target mitotic cells, as well as escaping anti-cancer immune responses.…”

Section: Evidence For a Cervical Cancer Stem Cell Nichementioning

confidence: 99%

Dysregulation of Stemness Pathways in HPV Mediated Cervical Malignant Transformation Identifies Potential Oncotherapy Targets

Budhwani

Lukowski

Porceddu

et al. 2020

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Human papillomavirus (HPV) infection is associated with a range of malignancies that affect anogenital and oropharyngeal sites. α-HPVs dominantly infect basal epithelial cells of mucosal tissues, where they dysregulate cell division and local immunity. The cervix is one of the mucosal sites most susceptible to HPV infections. It consists of anatomically diverse regions, and the majority of cervical intraepithelial neoplasia and cancers arise within the cervical squamo-columnar junction where undifferentiated basal progenitor cells with stem cell properties are found. The cancer stem cell theory particularly associates tumorigenesis, invasion, dissemination, and metastasis with cancer cells exhibiting stem cell properties. In this perspective, we discuss evidence of a cervical cancer stem cell niche and explore the association of stemness related genes with 5-year survival using a publicly available transcriptomic dataset of a cervical cancer cohort. We report that poor prognosis in this cohort correlates with overexpression of a subset of stemness pathway genes, a majority of which regulate the central Focal Adhesion pathway, and are also found to be enriched in the HPV infection pathway. These observations support therapeutic targeting of stemness genes overexpressed by mucosal cells infected with high-risk HPVs.

show abstract

<p>Self-Renewal Signalling Pathway Inhibitors: Perspectives on Therapeutic Approaches for Cancer Stem Cells</p>

Cited by 24 publications

References 132 publications

Signaling pathways governing breast cancer stem cells behavior

Signaling pathways governing breast cancer stem cells behavior

Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs

Dysregulation of Stemness Pathways in HPV Mediated Cervical Malignant Transformation Identifies Potential Oncotherapy Targets

Contact Info

Product

Resources

About