&lt;p&gt;Secretory Pathway Kinase &lt;em&gt;FAM20C&lt;/em&gt;, a Marker for Glioma Invasion and Malignancy, Predicts Poor Prognosis of Glioma&lt;/p&gt;

Du, Shaonan; Guan, Sheng; Zhu, Chen; Guo, Qing; Cao, Ji; Guan, Gefei; Cheng, Wen; Peng, Cheng; Wu, Anhua

doi:10.2147/ott.s275452

Cited by 14 publications

(15 citation statements)

References 46 publications

(62 reference statements)

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“…A latest study by Du et al reported the secretary pathway kinase or kinase-like proteins signature for glioblastoma (GBM) prognosis [23]. In this report, they also found an evident correlation between the elevated Fam20C expression and the progressed glioma malignancy, as well as the coherence between the elevated Fam20C expression and the disrupted immune response in the GBM microenvironment.…”

Section: The Roles Of Fam20c In Tumorogenesissupporting

confidence: 59%

From biomineralization to tumorogenesis—the expanding insight of the physiological and pathological roles of Fam20C

Wang

Liu

2021

Bioscience Reports

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Fam20C is a Golgi kinase phosphorylating the majority of the secreted proteins. In this decade, the roles of Fam20C has been largely disclosed in the loss-of function models. How the influence of the over-expressed Fam20C on cells or organs, and whether Fam20C was associated to tumorogensis still remain unknown. In the latest publication in Bioscience Reports, a group from the second affiliated hospital of Harbin Medical University established a correlation between the elevated Fam20C expression and the poor prognosis of multiple cancers. In addition, they also proposed the potential mechanisms how the increased Fam20C expression played a detrimental role in tumor progression by suggesting that the up-regulated Fam20C level impacted the infiltration of immune cells and the capability of cancer metastasism. To give an overview of the expanding knowledge of Fam20C involved in the physiological and pathological events, we first reviewed the history of Fam20C studies in this commentary, then, evaluated the correlation of the elevated Fam20C expression to the prognosis of multiple cancers, and finally, interpreted the perspectives that the Fam20C gain-of-function model was also critical for cancer therapy.

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Section: The Roles Of Fam20c In Tumorogenesissupporting

confidence: 59%

From biomineralization to tumorogenesis—the expanding insight of the physiological and pathological roles of Fam20C

Wang

Liu

2021

Bioscience Reports

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“…A Fam20C inhibitor induced cell apoptosis through the mitochondrial pathway and had the potential to inhibit cell migration ( Qin et al, 2016 ; Zhao R. et al, 2021 ). Shaonan Du et al found that Fam20C may serve as a predictive protein and a therapeutic target for GBM ( Du et al, 2020 ). However, there have been few studies on the Fam20C gene in LGG.…”

Section: Discussionmentioning

confidence: 99%

“…Non-biotin universal two-step immunohistochemistry kit (mouse/rabbit enhanced polymer detection system) was purchased from Beijing Zhongshan Jinqiao Biotechnology Co., Ltd. The positive control tissue in this experiment was glioblastoma tumor tissues ( Du et al, 2020 ). Results interpretation criteria: Fam20C positive expression means brown-yellow particles in the nucleus and cytoplasm.…”

Section: Methodsmentioning

confidence: 99%

Fam20C Overexpression Predicts Poor Outcomes and is a Diagnostic Biomarker in Lower-Grade Glioma

Feng

Zhou²,

Zhao³

et al. 2021

Front. Genet.

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Glioma is a relatively low aggressive brain tumor. Although the median survival time of patients for lower-grade glioma (LGG) was longer than that of patients for glioblastoma, the overall survival was still short. Therefore, it is urgent to find out more effective molecular prognostic markers. The role of the Fam20 kinase family in different tumors was an emerging research field. However, the biological function of Fam20C and its prognostic value in brain tumors have rarely been reported. This study aimed to evaluate the value of Fam20C as a potential prognostic marker for LGG. A total of 761 LGG samples (our cohort, TCGA and CGGA) were included to investigate the expression and role of Fam20C in LGG. We found that Fam20C was drastically overexpressed in LGG and was positively associated with its clinical progression. Kaplan-Meier analysis and a Cox regression model were employed to evaluate its prognostic value, and Fam20C was found as an independent risk factor in LGG patients. Gene set enrichment analysis also revealed the potential signaling pathways associated with Fam20C gene expression in LGG; these pathways were mainly enriched in extracellular matrix receptor interactions, cell adhesion, cell apoptosis, NOTCH signaling, cell cycle, etc. In summary, our findings provide insights for understanding the potential role of Fam20C and its application as a new prognostic biomarker for LGG.

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“…FAM20C is widely expressed across many types of cancers compared with the adjacent normal tissues. Moreover, the FAM20C expression is positively associated with a poor prognosis in breast, lung, and colorectal cancers, as well as glioblastoma [ 32 , 33 ]. Our results have shown that A549 and H460 cells abundantly produced phosphorylated OPN.…”

Section: Discussionmentioning

confidence: 99%

Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility

et al. 2021

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Osteopontin (OPN) plays a pivotal role in cancer cell invasion and metastasis. Although OPN has a large number of phosphorylation sites, the functional significance of OPN phosphorylation in cancer cell motility remains unclear. In this study, we attempted to investigate whether phosphorylated OPN secreted from cancer cells affect cancer cell migration. Quantitative PCR and Western blot analyses revealed that MDA-MB435S, A549, and H460 cells highly expressed OPN, whereas the OPN expression levels in H358, MIAPaca-2, and Panc-1 cells were quite low or were not detected. Compared with the cancer cell lines with a low OPN expression, the high OPN-expressing cancer cell lines displayed a higher cell migration, and the cell migration was suppressed by the anti-OPN antibody. This was confirmed by the OPN overexpression in H358 cancer cells with a low endogenous OPN. Phos-tag ELISA showed that phosphorylated OPN was abundant in the cell culture media of A549 and H460 cells, but not in those of MDA-MB435S cells. Moreover, the A549 and H460 cell culture media, as well as the MDA-MB435S cell culture media with a kinase treatment increased cancer cell motility, both of which were abrogated by phosphatase treatment or anti-OPN antibodies. These results suggest that phosphorylated OPN secreted from cancer cells regulates cancer cell motility.

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<p>Secretory Pathway Kinase <em>FAM20C</em>, a Marker for Glioma Invasion and Malignancy, Predicts Poor Prognosis of Glioma</p>

Cited by 14 publications

References 46 publications

From biomineralization to tumorogenesis—the expanding insight of the physiological and pathological roles of Fam20C

From biomineralization to tumorogenesis—the expanding insight of the physiological and pathological roles of Fam20C

Fam20C Overexpression Predicts Poor Outcomes and is a Diagnostic Biomarker in Lower-Grade Glioma

Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility

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