“…VEGF is the primary mediator of abnormal diabetic glomerular angiogenesis. Although the beneficial effects of anti-VEGF antibodies have been confirmed in diabetic animal experiments, recent basic and clinical evidence has suggested that blocking VEGF signaling can lead to proteinuria and renal thrombotic microangiopathy ( 17 ), indicating the importance of the normal levels of VEGF in the kidney. Therefore, anti-angiogenic treatment of DN should eliminate the excessive angiogenic response of the glomeruli without accelerating endothelial damage.…”