&lt;p&gt;Risk factors of ventilator-associated pneumonia in elderly patients receiving mechanical ventilation&lt;/p&gt;

Xu, Yue; Chunyun, Lai; Meng, Wenwen; Zhang, Jie; Hou, Hongyan; Pi, Hongying

doi:10.2147/cia.s197146

Cited by 27 publications

(25 citation statements)

References 59 publications

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“…Accumulating results verified that the use of ventilator and arteriovenous catheterization was associated with an invasive medical device or invasive procedure, which are independent risk factors for nosocomial bacteria infection. 20,25 The results of this study showed that the probability of nosocomial bacteria infection increased in patients using a ventilator. Intravenous catheterization can lead to colonization as well as a broad spectrum of infections ranging from catheter site infections to catheter-related blood stream infections.…”

Section: Discussionmentioning

confidence: 76%

<p>Analysis of the Risk Factors for Nosocomial Bacterial Infection in Patients with COVID-19 in a Tertiary Hospital</p>

Keping¹,

He²,

Qin³

et al. 2020

RMHP

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Section: Discussionmentioning

confidence: 76%

<p>Analysis of the Risk Factors for Nosocomial Bacterial Infection in Patients with COVID-19 in a Tertiary Hospital</p>

Keping¹,

He²,

Qin³

et al. 2020

RMHP

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“…DM or previous chronic pulmonary disease did not predispose to pneumonia in the present study. Although studies of OI and pneumonia remain scarce, in different OI settings both DM and COPD have been identified as significant risk factors for nosocomial pulmonary infections, and patients with DM have been shown to have different and rarer bacterial strains and a significantly higher drug resistance rate than patients without DM [28][29][30][31]. In large cohorts, the pneumonia risk in DM patients seems obvious; López-de-Andrés et al [32] reported a 21% higher incidence of postoperative pneumonia in DM patients than in non-diabetic patients in a cohort of over 100,000 patients, although contradictory results have also been reported [33,34].…”

Section: Discussionmentioning

confidence: 99%

Deep odontogenic infections—identifying risk factors for nosocomial pneumonia

et al. 2020

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Objectives To evaluate occurrence and risk factors for pneumonia in patients with deep odontogenic infection (OI). Materials and methods All patients treated for deep OIs and requiring intensive care and mechanical ventilation were included. The outcome variable was diagnosis of nosocomial pneumonia. Primary predictor variables were re-intubation and duration of mechanical ventilation. The secondary predictor variable was length of hospital stay (LOHS). The explanatory variables were gender, age, current smoking, current heavy alcohol and/or drug use, diabetes, and chronic pulmonary disease. Results Ninety-two patients were included in the analyses. Pneumonia was detected in 14 patients (15%). It was diagnosed on postoperative day 2 to 6 (median 3 days, mean 3 days) after primary infection care. Duration of mechanical ventilation (p = 0.028) and LOHS (p = 0.002) correlated significantly with occurrence of pneumonia. In addition, re-intubation (p = 0.004) was found to be significantly associated with pneumonia; however, pneumonia was detected in 75% of these patients prior to re-intubation. Two patients (2%) died during intensive care unit stay, and both had diagnosed nosocomial pneumonia. Smoking correlated significantly with pneumonia (p = 0.011). Conclusion Secondary pneumonia due to deep OI is associated with prolonged hospital care and can predict the risk of death. Duration of mechanical ventilation should be reduced with prompt and adequate OI treatment, whenever possible. Smokers with deep OI have a significantly higher risk than non-smokers of developing pneumonia. Clinical relevance Nosocomial pneumonia is a considerable problem in OI patients with lengthy mechanical ventilation. Prompt and comprehensive OI care is required to reduce these risk factors.

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“…For some patients who needed catheter insertion, such as nasal catheter, mask, tracheal intubation and so on, bacteria easily entered the body through the catheter cavity and lead to catheter-related infection finally. The untimely treatment of such infection often resulted in death [ 12 ]. Based on this background, we studied the effects of EAT on 30-day mortality and hospital length of stay.…”

Section: Introductionmentioning

confidence: 99%

Effect on 30-day mortality and duration of hospitalization of empirical antibiotic therapy in CRGNB-infected pneumonia

Tang

et al. 2021

Ann Clin Microbiol Antimicrob

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Background The objective of this study was to investigate whether unreasonable empirical antibiotic treatment (UEAT) had an impact on 30-day mortality and duration of hospitalization in bacterial pneumonia caused by carbapenem-resistant gram-negative bacteria (CRGNB). Methods This was a retrospective cohort study involving CRGNB-infected pneumonia. All CRGNB-infected pneumonia patients received empirical and targeted antibiotic treatment (TAT), and they were divided into reasonable empirical antibiotic treatment (REAT) and UEAT according to whether the empirical antibiotic treatment (EAT) was reasonable. The data of the two groups were compared to analyze their influence on the 30-day mortality and hospitalization time in CRGNB-infected pneumonia patients. Moreover, we also considered other variables that might be relevant and conducted multivariable regression analysis of 30-day mortality and duration of hospitalization in CRGNB-infected pneumonia patients. Results The study collected 310 CRGNB-infected pneumonia patients, the most common bacterium is Acinetobacter baumannii (211/310 [68%]), the rest were Klebsiella pneumoniae (46/310 [15%]), Pseudomonas aeruginosa and others (53/310 [17%]). Among them, 76/310 (24.5%) patients received REAT. In the analysis of risk factors, dementia, consciousness were risk factors of 30-day mortality, pulmonary disease, hemodynamic support at culture taken day and recent surgery were risk factors for longer hospital stay. The analysis of 30-day mortality showed that UEAT was not associated with 30-day mortality for the 30-day mortality of REAT and UEAT were 9 of 76 (11.84%) and 36 of 234 (15.38%) (P = 0.447), respectively. Meanwhile, there was difference between REAT and UEAT (P = 0.023) in the analysis of EAT on hospitalization time in CRGNB-infected pneumonia patients. Conclusions UEAT was not associated with 30-day mortality while was related to duration of hospitalization in CRGNB-infected pneumonia patients, in which Acinetobacter baumanniii accouned for the majority.

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<p>Risk factors of ventilator-associated pneumonia in elderly patients receiving mechanical ventilation</p>

Cited by 27 publications

References 59 publications

<p>Analysis of the Risk Factors for Nosocomial Bacterial Infection in Patients with COVID-19 in a Tertiary Hospital</p>

<p>Analysis of the Risk Factors for Nosocomial Bacterial Infection in Patients with COVID-19 in a Tertiary Hospital</p>

Deep odontogenic infections—identifying risk factors for nosocomial pneumonia

Effect on 30-day mortality and duration of hospitalization of empirical antibiotic therapy in CRGNB-infected pneumonia

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