<p>Risk factors for developing depression in women with cervical cancer: a nationwide population-based study in Taiwan</p>

Abstract

IntroductionDepression might affect women with cervical cancer and can deteriorate their quality of life or even their compliance with cancer treatments. The aim of this study was to investigate the incidence of depression and risk factors for developing depression among women with cervical cancer in Taiwan.Patients and methodsThis study enrolled patients with newly diagnosed cervical cancer from the National Health Insurance Research Database in Taiwan. From a population of 21,400,826 residents, each cervical cancer patient was matched with one subject without cervical cancer according to sex, age, and comorbidities with the same diagnostic index. The International Classification of Diseases, Ninth Revision, code 180.9 was used to identify patients with cervical cancer, and 296.0X–296.1X, 296.4X–296.8X, 296.2X–296.3X, 300.4, and 311.X codes were used to identify those with depressive disorders.ResultsIn total, 19,316 newly diagnosed cervical cancer patients were enrolled from January 2000 to December 2005, and the median follow-up period was 5.23 years (1.75–8.48 years). The prevalence of depressive disorder was 4.21% (813 of 19,316) in the cervical cancer cohort, and it was 3.85% (744 of 19,316) in the control cohort. The incidence risk ratio of depressive disorders was 1.35 (95% CI =1.22–1.49, P<0.001) among these cervical cancer patients. Cervical cancer, as an independent risk factor, was associated with developing subsequent depressive disorder. In addition, being older (≥65 years old) and the comorbidities of diabetes mellitus, ischemic heart disease, and cerebrovascular disease were also risk factors for predicting depressive disorder in cervical cancer patients.DiscussionCervical cancer is a prominent risk factor for the development of depression in women with cervical cancer in Taiwan. The patients with comorbidities, including diabetes mellitus, ischemic heart disease, and cerebrovascular disease, have higher risks of developing depression. However, there were no significant differences among the cervical cancer treatment modalities. In conclusion, these patients require early psychological support and intervention.

Risk of major depressive disorder in Japanese cancer patients: A matched cohort study using employer‐based health insurance claims data

“…Indeed, subgroup analysis of cancer patients suggested that those who received inpatient chemotherapy within 2 months of diagnosis, reflecting more serious cancer at diagnosis, had a higher risk of MDD. Previous matched cohort studies have reported increased risk of depression in patients with uterine, 22 head and neck, 27 lung, 24 colorectal, 28,29 thyroid, 30 gastric, 31 cervical, 32 and breast cancer, 33 as well as Hodgkin lymphoma 34 . The size of our study allowed us to determine the risk of MDD for many more types of cancer than previously studied.…”

“…In addition, most patients with cancer at multiple sites had metastatic cancer, which is usually more advanced and associated with worse outcomes. Cancers with better prognoses (eg, thyroid cancer) generally had lower risks of MDD, although patients with breast cancer, which has a 5-year relative survival rate 25 and conditional 5-year relative survival rate 26 22 head and neck, 27 lung, 24 colorectal, 28,29 thyroid, 30 gastric, 31 cervical, 32 and breast cancer, 33 as well as Hodgkin lymphoma. 34 The size of our study allowed us to determine the risk of MDD for many more types of cancer than previously studied.…”

Factors Affecting Occurrence of Depression in Patients with Cervical Cancer at Dr. Moewardi Hospital Surakarta, Central Java: A Path Analysis Model

“…The release of proinflammatory cytokines during cell damage induced by chemotherapy can affect the pathophysiology of mood disorders. Side effects from chemotherapy such as alopecia, nausea and vomiting further increase the risk of depression and anxiety (Shyu et al, 2019).…”

“…In addition, patients who receive cancer chemotherapy treatment, may experience delayed symptoms, including sleep disorders, depressed moods, and fatigue. This is more likely to develop depression (Shyu et al, 2019). There is a need to prevent depression and anxiety in long-term cancer patients, individual treatment of physical and psychological symptoms which is as important as social support and professional counseling (Götze et al, 2019).…”

Association of supportive care needs and quality of patient‐centered cancer care with depression in women with breast and cervical cancer in Mexico

“…Depression in women with breast cancer is more closely associated with patients' sociodemographic characteristics than to the disease or its treatment 9 . Meanwhile, several studies have attributed depression to clinical and social factors, such as advanced cancer stage, comorbidity, severity of symptoms, and lack of social support 10‐13 …”