&lt;p&gt;Review of Research on the Role of Irisin in Tumors&lt;/p&gt;

Zhang, Deguo; Tan, Xueying; Tang, Nan; Huang, Fei; Chen, Zeng‐yin; Shi, Guangjun

doi:10.2147/ott.s245178

Cited by 36 publications

(21 citation statements)

References 49 publications

(73 reference statements)

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“…However, irisin also appears to have a positive effect on cognitive function and to play a role in bone metabolism regulation [2,123]. Finally, recent studies have shown that malignant cells have a higher concentration of irisin than normal ones [124]. Irisin function is apparently contradictory because it is able to induce both cytoprotection and cell death in a plasma concentration-dependent manner.…”

Section: Irisinmentioning

confidence: 99%

Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging

Mancinelli

Checcaglini

Coscia

et al. 2021

IJMS

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In the last decade, clear evidence has emerged that the cellular components of skeletal muscle are important sites for the release of proteins and peptides called “myokines”, suggesting that skeletal muscle plays the role of a secretory organ. After their secretion by muscles, these factors serve many biological functions, including the exertion of complex autocrine, paracrine and/or endocrine effects. In sum, myokines affect complex multi-organ processes, such as skeletal muscle trophism, metabolism, angiogenesis and immunological response to different physiological (physical activity, aging, etc.) or pathological states (cachexia, dysmetabolic conditions, chronic inflammation, etc.). The aim of this review is to describe in detail a number of myokines that are, to varying degrees, involved in skeletal muscle aging processes and belong to the group of proteins present in the functional environment surrounding the muscle cell known as the “Niche”. The particular myokines described are those that, acting both from within the cell and in an autocrine manner, have a defined relationship with the modulation of oxidative stress in muscle cells (mature or stem) involved in the regulatory (metabolic or regenerative) processes of muscle aging. Myostatin, IGF-1, NGF, S100 and irisin are examples of specific myokines that have peculiar features in their mechanisms of action. In particular, the potential role of one of the most recently characterized myokines—irisin, directly linked to an active lifestyle—in reducing if not reversing senescence-induced oxidative damage is discussed in terms of its possible application as an agent able to counteract the deleterious effects of muscle aging.

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Section: Irisinmentioning

confidence: 99%

Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging

Mancinelli

Checcaglini

Coscia

et al. 2021

IJMS

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“…The biological effects of the botanical oils on insect pests may attribute to their effect on the insect neuro endocrine system and juvenile hormone leading to hormone unbalance occurring malformation and decreasing moths fecundity and egg fertility resembling the effect of the growth regulators as concluded by Sharaby, A. and A. El-Nojiban [29]. Huang et al [30] attributed decreasing of fecundity and fertility to decreasing in periods and time of adults mating which lead to decreasing of ovulation, essential oils have neuro toxic, citotoxic and mutagenic actions among other different insects as investigated by Isman, M.B. ; S. Miresmailli and C.…”

Section: Effects Of Peppermint Oil Nano-formulations On Different Biomentioning

confidence: 99%

Efficiency of Nano-formulations of Neem and Peppermint Oils on the Bionomics and Enzymatic Activities of <i>Agrotis ipsilon</i> Larvae (Lepidoptera: Noctuidae)

Amin¹,

Bayoumi²,

Dimetry³

et al. 2019

IJNREM

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Nanotechnology is considered to be a development way to gain efficient and potential approaches towards pest control. The effect of both neem and peppermint oils as bulk, nano and loaded nano-emulsions have been studied against the different biological aspects of the 2 nd larval instar of Agrotis ipsilon (Hufn.) under laboratory conditions. Their effects on enzymatic activities were investigated for the 2 nd and 4 th larval instars. The effects of adding the different formulations of either neem or peppermint oils to artificial diet of 2 nd instar larvae show significant elongation of the larval duration; percentage mortalities were increased as well as larval malformations. It was recorded that nano-formulations (emulsion or loaded) significantly decreased the pupal weight and significantly increased the pupal duration, percentage pupal mortalities and pupal malformation. Adult longevity show insignificant effect, while female fecundity and percentage egg fertility show significant decrease in comparison with the control. Results of enzymatic activities show marked effects of the three formulations of either neem or peppermint oil. Significant inhibitions were recorded for amylase, invertase, trehalase, protease and alkaline phosphatase. However, significant increase in the activities of cuticle phenoloxidase and chitinase were recorded. Marked variations were recorded between nano-formulations and the bulk form.

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“…The studies are presented chronologically, and summary data tables are included. It should be noted that a number of related past reviews exist [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]; however, the present review provides updated information and adds to the existing literature.…”

Section: Introductionmentioning

confidence: 99%

Current Evidence of the Role of the Myokine Irisin in Cancer

Tsiani

Tsakiridis

Kouvelioti

et al. 2021

Cancers

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Cancer is a disease associated with extreme human suffering, a huge economic cost to health systems, and is the second leading cause of death worldwide. Regular physical activity is associated with many health benefits, including reduced cancer risk. In the past two decades, exercising/contracting skeletal muscles have been found to secrete a wide range of biologically active proteins, named myokines. Myokines are delivered, via the circulation, to different cells/tissues, bind to their specific receptors and initiate signaling cascades mediating the health benefits of exercise. The present review summarizes the existing evidence of the role of the myokine irisin in cancer. In vitro studies have shown that the treatment of various cancer cells with irisin resulted in the inhibition of cell proliferation, survival, migration/ invasion and induced apoptosis by affecting key proliferative and antiapoptotic signaling pathways. However, the effects of irisin in humans remains unclear. Although the majority of the existing studies have found reduced serum irisin levels in cancer patients, a few studies have shown the opposite. Similarly, the majority of studies have found increased levels of irisin in cancer tissues, with a few studies showing the opposite trend. Clearly, further investigations are required to determine the exact role of irisin in cancer.

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<p>Review of Research on the Role of Irisin in Tumors</p>

Cited by 36 publications

References 49 publications

Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging

Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging

Efficiency of Nano-formulations of Neem and Peppermint Oils on the Bionomics and Enzymatic Activities of <i>Agrotis ipsilon</i> Larvae (Lepidoptera: Noctuidae)

Current Evidence of the Role of the Myokine Irisin in Cancer

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<p>Review of Research on the Role of Irisin in Tumors</p>

Cited by 36 publications

References 49 publications

Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging

Biological Aspects of Selected Myokines in Skeletal Muscle: Focus on Aging

Efficiency of Nano-formulations of Neem and Peppermint Oils on the Bionomics and Enzymatic Activities of &lt;i&gt;Agrotis ipsilon&lt;/i&gt; Larvae (Lepidoptera: Noctuidae)

Current Evidence of the Role of the Myokine Irisin in Cancer

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Efficiency of Nano-formulations of Neem and Peppermint Oils on the Bionomics and Enzymatic Activities of <i>Agrotis ipsilon</i> Larvae (Lepidoptera: Noctuidae)