&lt;p&gt;Review of Curcumin Physicochemical Targeting Delivery System&lt;/p&gt;

Li, Lanmei; Zhang, Xiaomei; Pi, Chao; Yang, Hongxia; Zheng, Xiaoli; Zhao, Ling; Wei, Yumeng

doi:10.2147/ijn.s276201

Cited by 35 publications

(20 citation statements)

References 112 publications

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“…A recent study has suggested that curcumin blocks LPA-induced MCP-1 expression via TGFBR1/ROCK signaling pathway [ 103 ].Additional studies are required to improve or add meaningful insights into our understanding of the mechanism(s) of action of curcumin against atherosclerosis, especially in the clinical setting. In addition, the development of novel drug delivery systems, such as the creation of curcumin nanomicelles [ 104 , 105 ], is critical for improving the oral bioavailability of curcumin which may contribute to its clinical efficacy [ 106 ].…”

Section: Discussionmentioning

confidence: 99%

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Singh

Sharma

et al. 2021

Molecules

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Curcumin, a natural polyphenolic compound present in Curcuma longa L. rhizomes, shows potent antioxidant, anti-inflammatory, anti-cancer, and anti-atherosclerotic properties. Atherosclerosis is a comprehensive term for a series of degenerative and hyperplasic lesions such as thickening or sclerosis in large- and medium-sized arteries, causing decreased vascular-wall elasticity and lumen diameter. Atherosclerotic cerebro-cardiovascular disease has become a major concern for human health in recent years due to its clinical sequalae of strokes and heart attacks. Curcumin concoction treatment modulates several important signaling pathways related to cellular migration, proliferation, cholesterol homeostasis, inflammation, and gene transcription, among other relevant actions. Here, we provide an overview of curcumin in atherosclerosis prevention and disclose the underlying mechanisms of action of its anti-atherosclerotic effects.

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Section: Discussionmentioning

confidence: 99%

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Singh

Sharma

et al. 2021

Molecules

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“…Additional studies are required to improve or add meaningful insights into our understandingof the mechanism of the action of curcumin against atherosclerosis in mice and human patients. In addition, the development of novel drug delivery systems, such as the creation of curcumin nanomicelles [84,85], is critical for improving curcumin oral bioavailability [86].…”

Section: Discussionmentioning

confidence: 99%

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Singh¹,

Sharma²,

Xu³

et al. 2021

Preprint

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Curcumin, a hydrophobic bioactive constituent from Curcuma longa, has several health promoting properties including anti-atherosclerotic properties. Further, curcumin has blood glucose- and lipid-lowering properties, prophylactic, and therapeutic effects in other cardiometabolic diseases. Atherosclerosis is an umbrella term for a series of degenerative and hyperplasic lesions such as thickening or sclerosis in large and medium -sized artery walls that decrease vascular-wall elasticity and lumen diameter. The atherosclerotic cerebro-cardiovascular disease has become a major concern to human health in recent years. Considering the notable cardiovascular actions of curcumin, the present review summarizes the current status and future perspective of research on curcumin and its ability to prevent or treat atherosclerosis

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“…However, its beneficial effects are limited due to the poor absorption efficacy. Employing nanocarriers such as liposomes, microspheres, emulsions, and micelles has been investigated as a promising strategy to enhance the bioavailability of curcumin [63][64][65].…”

Section: Liver Targeting Of Nanoparticlesmentioning

confidence: 99%

The Emerging Role of Nanomedicine in the Management of Nonalcoholic Fatty Liver Disease: A State-of-the-Art Review

Moosavian

Sathyapalan

Jamialahmadi

et al. 2021

Bioinorganic Chemistry and Applications

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Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can lead to end-stage liver disease needing a liver transplant. Many pharmacological approaches are used to reduce the disease progression in NAFLD. However, current strategies remain ineffective to reverse the progression of NAFLD completely. Employing nanoparticles as a drug delivery system has demonstrated significant potential for improving the bioavailability of drugs in the treatment of NAFLD. Various types of nanoparticles are exploited in this regard for the management of NAFLD. In this review, we cover the current therapeutic approaches to manage NAFLD and provide a review of recent up-to-date advances in the uses of nanoparticles for the treatment of NAFLD.

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<p>Review of Curcumin Physicochemical Targeting Delivery System</p>

Cited by 35 publications

References 112 publications

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

The Emerging Role of Nanomedicine in the Management of Nonalcoholic Fatty Liver Disease: A State-of-the-Art Review

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