<p>Relationship of glucose-6-phosphate dehydrogenase deficiency and neonatal sepsis: a single-center investigation on the major cause of neonatal morbidity and mortality</p>

Abstract

Introduction: Neonatal sepsis is a serious disease with distinct clinical and laboratory findings. G6PD deficiency is known as the most common human erythrocyte-enzyme deficiency. This study was designed to investigate the relationship between G6PD deficiency and neonatal sepsis, since it is a major cause of neonatal morbidity and mortality. Methods: A cross-sectional case–control study was designed and performed on 50 neonates who had been admitted to the neonatal intensive-care unit and diagnosed with sepsis and 50 normal neonate controls. Quantitative G6PD-enzyme activity was assessed in the case and control groups. Results: Quantitative G6PD-level assessment showed that five (5%) subjects in the case group vs one (1%) of the control group were severely deficient and nine (9%) cases vs one (1%) control were moderately deficient. Enzyme-level differences were statistically significant ( P =0.003). Conclusion: Our study showed higher incidence of G6PD deficiency in neonates who had been admitted due to sepsis. We suggest quantitative G6PD-level assessment instead of the routine qualitative methods in prevalent G6PD deficiency. It is also recommended that neonates with G6PD deficiency be under close supervision during the first month of life, especially those with other risks of neonatal sepsis, such as prematurity or low birth weight.

Proteomic Analysis Identifies Molecular Players and Biological Processes Specific to SARS-CoV-2 Exposure in Endothelial Cells

“…Deficiency of this protein has been associated with a higher susceptibility to coronavirus infection and the severity of COVID-19 [34]. This protein is important for the maintenance of redox homeostasis, and a lack of G6PD has been implicated in several hematological disorders [35,36].…”

Severe G6PD deficiency leads to recurrent infections and defects in ROS production: Case report and literature review

“…Only 620 of 3,334 registered G6PD-deficient patients did not have any microbiological cultures or hospitalization details. The incidence of G6PD deficiency in septic neonates was significantly higher than that in the control group ( Zekavat et al, 2019 ); therefore, G6PD deficiency has been considered to be a risk factor for neonatal sepsis ( Rostami-Far et al, 2016 ). It is necessary to focus on the clinical manifestations and immune function of patients with G6PD deficiency.…”

Functional characterization of the p.(Gln195His) or Tainan and novel p.(Ser184Cys) or Toluca glucose-6-phosphate dehydrogenase (G6PD) gene natural variants identified through Mexican newborn screening for glucose-6-phosphate dehydrogenase deficiency

“…La coincidencia de sepsis neonatal y dG6PD, favorece la expresión atípica de la ictericia neonatal, con mayor intensidad en la hiperbilirrubinemia, así como mayor duración y frecuentes complicaciones como la colestasis. 24 Algunas de las sustancias asociadas con la hemólisis neonatal incluyen; naftaleno que se utiliza para almacenar ropa, medicinas herbolarias, aplicaciones de henna o mentol utilizado para limpieza umbilical. 25 Tabla 5.…”