&lt;p&gt;RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes&lt;/p&gt;

Mavilio, Alberto; Sisto, Dario; Ferreri, Paolo; Dammacco, Rosanna; Alessio, Giovanni

doi:10.2147/opth.s211337

Cited by 5 publications

(17 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[26][27][28] There is, however, a paucity of information of PERG features in patients with both glaucoma and high myopia, with only 1 other study investigating this in the literature. 29 In our observational study, we aimed to investigate the characteristics of ssPERG in subjects with glaucoma and high myopia. The identification of specific ssPERG features may aid in distinguishing between both conditions.…”

Section: Introductionmentioning

confidence: 99%

Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia

Lim¹,

Nongpiur²,

Najjar³

et al. 2021

OPTH

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia

Lim¹,

Nongpiur²,

Najjar³

et al. 2021

OPTH

View full text Add to dashboard Cite

“…At the same way, it is also known that age-related visual conditions such as age itself, presbyopia and cataract can influence PERG. As for cataract, we showed reduced amplitude with small intrinsic variability of the phase in a RE-PERG pilot study,[ 57 ] but further studies are required also in the other above-mentioned conditions. Our results suggest that RE-PERG is a quick, easy to perform and non-invasive test able to detect RGC dysfunction in AD, but despite its promise its utility must be confirmed in other laboratories and in larger cohorts of patients.…”

Section: Discussionmentioning

confidence: 88%

“…In previous studies we showed that phase variability is higher in glaucoma patients and that it is not influenced by cataract or myopia. [ 57 , 58 ] Since the neurodegeneration of RGCs shows similar features in glaucoma and AD, we examined the ability of RE-PERG to identify early-stage AD and to discriminate AD from VD on the basis of the different mechanisms of neurodegeneration. The results showed a slightly significant reduction in the PERG Amp value in AD patients vs. NC, but no difference between VD patients and NCs.…”

Section: Discussionmentioning

confidence: 99%

“…The criteria for the clinical and instrumental ophthalmic evaluation were the same as used in previous studies. [56][57][58]…”

Section: Ophthalmic Examinationmentioning

confidence: 99%

“…[ 56 ] Moreover, unlike the amplitude, phase variability is not influenced by optical media opacities and myopia. [ 57 , 58 ] Second-level imaging-based tests for the diagnosis of AD and VD are often expensive and not always available, especially in rural hospitals, such that diagnostic tools based on biomarkers able to distinguish among the various types of dementia are needed. RE-PERG uses high temporal frequency stimuli able to evoke a response of the M system.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

RE-PERG in early-onset Alzheimer’s disease: A double-blind, electrophysiological pilot study

et al. 2020

Self Cite

View full text Add to dashboard Cite

Purpose To evaluate the ability of re-test pattern electroretinogram (RE-PERG), a non-invasive and fast steady-state PERG, to detect inner retinal bioelectric function anomalies in patients with early-onset Alzheimer’s disease (AD). Methods The study population consisted of 17 patients with AD-related mild cognitive impairment (MCI), 16 patients with vascular dementia (VD)-related MCI, both assessed using the neuropsychological Mini-Mental State Examination (MMSE) and by structural magnetic resonance imaging, and 19 healthy, age-matched normal controls (NC). All participants were visually asymptomatic, had normal or near-normal general cognitive functioning and no or minimal impairments in daily life activities. Visual field (VF) test, optical coherence tomography (OCT) and RE-PERG, sampled in five consecutive blocks of 130 events, were performed. Results There was no statistically significant difference among the three groups with respect to age, VF parameters (mean and pattern standard deviations) and OCT parameters (ganglion cell complex thickness and retinal nerve fiber layer thickness). The mean amplitude in the RE-PERG was significantly lower, but only weakly in the AD group than in NC (p = 0.1) whereas the intrinsic variability of the 2nd harmonic phase was significantly higher in the AD group than in either the VD or NC group (p<0.001). Conclusions RE-PERG is altered in early-stage AD, showing a reduced amplitude with high intrinsic phase variability. It also allows the discrimination of AD from VD. A high intrinsic variability in the PERG signal, determined using RE-PERG, may thus be a new promising test for neurodegenerative diseases.

show abstract

Handheld chromatic pupillometry can reliably detect functional glaucomatous damage in eyes with high myopia

Finkelstein

Nongpiur

Husain

et al. 2022

Preprint

View full text Add to dashboard Cite

Purpose: To assess pupillary light responses (PLRs) in eyes with high myopia and evaluate the ability of handheld chromatic pupillometry (HCP) to identify glaucomatous functional loss in eyes with high myopia. Design: Cross-sectional study with prospective data collection. Methods: Participants included 28 emmetropes (EM), 24 high myopes without glaucoma (HM), and 17 high myopes with confirmed glaucoma (HMG), recruited at the Singapore National Eye Center. Monocular PLRs were evaluated using a custom-built handheld pupillometer that recorded changes in horizontal pupil radius in response to 9 seconds of exponentially increasing blue (469.1nm) and red (640.1nm) lights. Fifteen pupillometric features were compared between groups. A logistic regression model (LRM) was used to distinguish HMG eyes from non-glaucomatous eyes (EM and HM). Results: All pupillometric features were similar between EM and HM groups. Phasic constriction to blue (P<0.001) and red (P=0.006) lights, and maximum constriction to blue light (P<0.001) were reduced in HMG compared to EM and HM. Pupillometric features of melanopsin function (PIPR AUC 0-12s (P<0.001) and PIPR 6s (P=0.01) to blue light) were reduced in HMG. Using only three pupillometric features, the LRM could classify glaucomatous from non-glaucomatous eyes with an AUC of 0.89 (95%CI: 0.77-1.00), sensitivity 94.1% (82.4%-100.0%) and specificity 78.8% (67.3%-90.4%). Conclusions: PLRs to ramping-up light stimuli are unaltered in highly myopic eyes without other diagnosed ocular conditions. Conversely, HCP can distinguish glaucomatous functional loss in highly myopic eyes and may be a useful tool to detect/confirm the presence of glaucoma in patients with high myopia.

show abstract

<p>RE-PERG, a new paradigm for glaucoma diagnosis, in myopic eyes</p>

Cited by 5 publications

References 27 publications

Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia

Steady-State Pattern Electroretinography in Eyes with Glaucoma and High Myopia

RE-PERG in early-onset Alzheimer’s disease: A double-blind, electrophysiological pilot study

Handheld chromatic pupillometry can reliably detect functional glaucomatous damage in eyes with high myopia

Contact Info

Product

Resources

About