&lt;p&gt;QbD-Based Investigation of Dermal Semisolid in situ Film-Forming Systems for Local Anaesthesia&lt;/p&gt;

Kovács, Anita; Kis, Nikolett; Budai-Szűcs, Mária; Gácsi, Attila; Csányi, Erzsébet; Csóka, Ildikó; Berkó, Szilvia

doi:10.2147/dddt.s279727

Cited by 8 publications

(4 citation statements)

References 37 publications

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“…Otherwise, bacterial proliferation may result in various associated diseases, such as hyponatremia and hypernatremia, hypokalemia and hyperkalemia, heart disorders, and cystic fibrosis. [54] Since, every cell organelle retains its intracellular pH (pHi) values as summarized in Table 1(b), which are frequently administered due to the continuous inter-conversion of CO 2 and HCO 3 À and can be construed in the following equation (1):…”

Section: Physiological Role and Scope Of Ph Sensingmentioning

confidence: 99%

“…pH values from 4–6, this acidic environment is provided by some amino acids and fatty acids that are helpful in bacterial inhibition. Otherwise, bacterial proliferation may result in various associated diseases, such as hyponatremia and hypernatremia, hypokalemia and hyperkalemia, heart disorders, and cystic fibrosis [54] …”

Section: Physiological Role and Scope Of Ph Sensingmentioning

confidence: 99%

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Advances in pH Sensing: From Traditional Approaches to Next‐Generation Sensors in Biological Contexts

Hassan Akhtar,

Azhar Hayat Nawaz,

Abbas

et al. 2024

The Chemical Record

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AbstractpH has been considered one of the paramount factors in bodily functions because most cellular tasks exclusively rely on precise pH values. In this context, the current techniques for pH sensing provide us with the futuristic insight to further design therapeutic and diagnostic tools. Thus, pH‐sensing (electrochemically and optically) is rapidly evolving toward exciting new applications and expanding researchers’ interests in many chemical contexts, especially in biomedical applications. The adaptation of cutting‐edge technology is subsequently producing the modest form of these biosensors as wearable devices, which are providing us the opportunity to target the real‐time collection of vital parameters, including pH for improved healthcare systems. The motif of this review is to provide insight into trending tech‐based systems employed in real‐time or in‐vivo pH‐responsive monitoring. Herein, we briefly go through the pH regulation in the human body to help the beginners and scientific community with quick background knowledge, recent advances in the field, and pH detection in real‐time biological applications. In the end, we summarize our review by providing an outlook; challenges that need to be addressed, and prospective integration of various pH in vivo platforms with modern electronics that can open new avenues of cutting‐edge techniques for disease diagnostics and prevention.

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Section: Physiological Role and Scope Of Ph Sensingmentioning

confidence: 99%

Section: Physiological Role and Scope Of Ph Sensingmentioning

confidence: 99%

Advances in pH Sensing: From Traditional Approaches to Next‐Generation Sensors in Biological Contexts

Hassan Akhtar,

Azhar Hayat Nawaz,

Abbas

et al. 2024

The Chemical Record

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show abstract

“…For instance, healthy skin retains the pH values between 4-6, this acidic environment is provided by some amino acids and fatty acids that is helpful in bacterial inhibition. Otherwise, bacterial proliferation may result in various associated diseases, such as hyponatremia and hypernatremia, hypokalemia and hyperkalemia, heart disorders and cystic fibrosis [55].…”

Section: Ph Regulation In Human Bodymentioning

confidence: 99%

pH Monitoring in Biological Environment: An Overview of Conventional to Cutting-Edge Sensing Platforms

Akhtar¹,

Nawaz²,

Liu³

et al. 2023

Preprint

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pH is considered one of the paramount factors in bodily functions, because most of the cellular tasks exclusively rely on precise pH values. The regulation of pH is a necessary feature of the intracellular atmosphere and can be established as a strong indicator to judge a physiological abnormality in most of the cases. In this context, the current techniques for pH sensing provide us with the futuristic insight to further design therapeutic and diagnostic tools. Thus, pH-sensing (electrochemically and optically) is rapidly evolving toward exciting new applications and expanding researchers’ interests in many chemical contexts, especially in biomedical applications. The adaptation of cutting-edge technology is subsequently producing the modest form of these biosensors as wearable devices, which are providing us the opportunity to target the real-time collection of vital parameters, including pH for improved healthcare systems. The motif of this review is to provide an insight of trending tech-based systems employed in real time or in-vivo pH responsive monitoring. Herein, we briefly go through the pH regulation in the human body to help the beginners and scientific community with quick background knowledge, recent advances in the field, and pH detection in cancerous environments. In the end, we summarize our review by providing an outlook; challenges that need to be addressed and prospective integration of various pH in vivo platforms with modern electronics that can open new avenues of cutting-edge techniques for disease diagnostics and prevention.

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“…The dynamic nature of FFS implies a need to define a tailored quality target product profile (QTPP), which can only be achieved by smart identification of critical quality attributes (CQAs) so that those product characteristics that have an impact on product quality can be further studied and controlled [ 12 , 13 ]. Apart from standard aspects relating to quality, safety and efficacy of preparations for cutaneous application, the so-called metamorphosis/transformation of FFS deserves careful assessment, considering its prospective influence on a number of properties (e.g., precipitation of the incorporated active pharmaceutical ingredient).…”

Section: Introductionmentioning

confidence: 99%

Coupling AFM, DSC and FT-IR towards Elucidation of Film-Forming Systems Transformation to Dermal Films: A Betamethasone Dipropionate Case Study

Timotijević

Ilić

Marković

et al. 2022

IJMS

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Polymeric film-forming systems have emerged as an esthetically acceptable option for targeted, less frequent and controlled dermal drug delivery. However, their dynamic nature (rapid evaporation of solvents leading to the formation of thin films) presents a true characterization challenge. In this study, we tested a tiered characterization approach, leading to more efficient definition of the quality target product profiles of film-forming systems. After assessing a number of physico-chemico-mechanical properties, thermal, spectroscopic and microscopic techniques were introduced. Final confirmation of betamethasone dipropionate-loaded FFS biopharmaceutical properties was sought via an in vitro skin permeation study. A number of applied characterization methods showed complementarity. The sample based on a combination of hydrophobic Eudragit® RS PO and hydroxypropyl cellulose showed higher viscosity (47.17 ± 3.06 mPa·s) and film thickness, resulting in sustained skin permeation (permeation rate of 0.348 ± 0.157 ng/cm2 h), and even the pH of the sample with Eudragit® NE 30D, along with higher surface roughness and thermal analysis, implied its immediate delivery through the epidermal membrane. Therefore, this study revealed the utility of several methods able to refine the number of needed tests within the final product profile.

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<p>QbD-Based Investigation of Dermal Semisolid in situ Film-Forming Systems for Local Anaesthesia</p>

Cited by 8 publications

References 37 publications

Advances in pH Sensing: From Traditional Approaches to Next‐Generation Sensors in Biological Contexts

Advances in pH Sensing: From Traditional Approaches to Next‐Generation Sensors in Biological Contexts

pH Monitoring in Biological Environment: An Overview of Conventional to Cutting-Edge Sensing Platforms

Coupling AFM, DSC and FT-IR towards Elucidation of Film-Forming Systems Transformation to Dermal Films: A Betamethasone Dipropionate Case Study

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