&lt;p&gt;Protective Effects of &lt;em&gt;Spirulina platensis&lt;/em&gt;, Voluntary Exercise and Environmental Interventions Against Adolescent Stress-Induced Anxiety and Depressive-Like Symptoms, Oxidative Stress and Alterations of BDNF and 5HT-3 Receptors of the Prefrontal Cortex in Female Rats&lt;/p&gt;

Kor, Nasroallah Moradi; Dadkhah, Masoomeh; Ghanbari, Ali; Rashidipour, Hadi; Bandegi, Ahmad Reza; Barati, Mehdi; Kokhaei, Parviz; Rashidy-Pour, Ali

doi:10.2147/ndt.s247599

Cited by 17 publications

(13 citation statements)

References 97 publications

(131 reference statements)

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“…The results for the effects of stress on depression are in line with previous studies that showed stress could induce depression and anxiety [8,21,22]. Stress increases depression and anxiety via increased levels of corticosterone [1,18]. Importantly, our findings showed that sake yeast alleviated the effects of stress.…”

Section: Discussionsupporting

confidence: 91%

“…The OFT was conducted to assess anxiety as reported by others [1]. Briefly, behavioral responses in time were investigated in a dark area (72×72×45 cm) for 20 minutes.…”

Section: Open-field Test (Oft)mentioning

confidence: 99%

“…Chronic stress in the pre-pubertal age is known to have adverse effects in progressing neuropsychiatric disorders in adulthood [1]. Adolescence is known as a sensitive age in which the development of psychopathology may occur [2].…”

Section: Introductionmentioning

confidence: 99%

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The effects of oral supplementation of Japanese sake yeast on anxiety, depressive-like symptoms, oxidative stress, and BDNF changes in chronically stressed adolescent rats

Haghipanah¹,

Saadat

Safarbalou³

et al. 2022

Preprint

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Chronic stress during the pre-pubertal period has adverse effects in developing neuropsychiatric disorders such as depression and anxiety. The administration of supplements with antioxidant properties may alleviate depression and anxiety behavior. This study investigated the effects of oral supplementation of Japanese sake yeast on anxiety, depressive-like symptoms, oxidative stress, and changes in brain-derived neurotropic factor (BDNF) in adolescence rats subjected to chronic stress. In order to assess the effects of chronic stress, adolescent rats were grouped into one non-stressed control group (non-stress) and four different experimental groups. The other animals were subjected to stress and orally received normal saline (Control-stress), 15 mg/kg yeast (Stress-15), 30 mg/kg yeast (Stress-30) and 45 mg/kg yeast (Stress-45). Anxiety and depression-like behavior, BDNF levels, and oxidative stress markers were evaluated. The rats exposed to stress exhibited anxiogenic and depression-like behavior as well as lower levels of BDNF and higher levels of oxidative markers compared with non-stressed rats (P<0.05). However, the oral supplementation of sake yeast decreased anxiogenic and depression-like behavior and oxidative indices, and also increased BDNF levels compared to stressed rats treated with saline in a dose-dependent manner (P<0.05). In sum, stress caused anxiety and depression behavior, increased oxidative indices, and reduced BDNF levels while sake yeast alleviated adverse effects of stress on anxiety and depression behaviors, decreased oxidative markers, and increased BDNF levels.

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Section: Discussionsupporting

confidence: 91%

“…The OFT was conducted to assess anxiety as reported by others [1]. Briefly, behavioral responses in time were investigated in a dark area (72×72×45 cm) for 20 minutes.…”

Section: Open-field Test (Oft)mentioning

confidence: 99%

See 1 more Smart Citation

The effects of oral supplementation of Japanese sake yeast on anxiety, depressive-like symptoms, oxidative stress, and BDNF changes in chronically stressed adolescent rats

Haghipanah¹,

Saadat

Safarbalou³

et al. 2022

Preprint

Self Cite

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show abstract

“…[90] It has been reported that neuronal damage due to chronic oxidative stress and inflammation leads to a reduction in prefrontal cortex size and dysfunction in the production of neurotransmitters in depressed patients. [91][92][93] There are many pieces of evidence that brain serotonin dysfunction plays an essential role in developing cardiac abnormalities via vasoconstriction and inflammation. [15,16,94] In the present study, RA (25 and 50 mg/kg) increased serotonin levels relative to the CUS-control group.…”

Section: Discussionmentioning

confidence: 99%

Prophylactic administration of rosmarinic acid ameliorates depression‐associated cardiac abnormalities in Wistar rats: Evidence of serotonergic, oxidative, and inflammatory pathways

Verma

Shivavedi

Tej

et al. 2022

J Biochem & Molecular Tox

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Psychiatric disorders and associated cardiac comorbidities have increased the risk of mortality worldwide. Researchers reported that depression increases the possibility of future cardiac abnormalities by approximately 30%. Therefore, there is an unmet need to develop therapeutic interventions to treat depression and associated cardiac abnormalities. The present study was conducted to evaluate the prophylactic effect of rosmarinic acid (RA) against chronic unpredictable stress (CUS)-induced depression associated cardiac abnormalities in Wistar rats. The CUS paradigm, which comprised several stressors, was employed for 40 days to induce depressive-like behavior and associated cardiac abnormalities in rats. Along with CUS, RA at a dose of 25 and 50 mg/kg was administered orally to two groups of animals for 40 days. Behavioral tests (forced swim test and sucrose consumption test) and molecular biomarkers (corticosterone and serotonin) were performed. Electrocardiography was performed before CUS (Day 0), Day 20, and Day 40 to study electrocardiogram parameters.Furthermore, changes in body weight, organ weight, tissue lipid peroxidation, glutathione, catalase, cTn-I, MMP-2, and proinflammatory cytokines (TNF-α and IL-6) were estimated. Our results showed that RA treatment caused a reduction in immobility period, adrenal hyperplasia, corticosterone level, tissue lipid peroxidation, cTn-I, MMP-2, proinflammatory cytokines, and QRS complex duration, while an increase in sucrose consumption, brain serotonin level, T-wave width, glutathione, and catalase activity as compared with the CUS-control group. The results of our study proved that RA administration ameliorates CUS-induced depression-associated cardiac abnormalities in rats via serotonergic, oxidative, and inflammatory pathways.

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“…Stress in adolescence is associated with enhanced anxiety levels and depression in adulthood, as well as elevated oxidative stress markers. Environmental enrichment, exercise, and treatment with Spirulina platensis tend to reduce oxidative damage induced by stress [ 106 ].…”

Section: Oxidative Stress Biomarkers and Pediatric Depressive Disordermentioning

confidence: 99%

Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review

Lee

Chi

Lee

2021

IJMS

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Depressive disorder in childhood and adolescence is a highly prevalent mood disorder that tends to recur throughout life. Untreated mood disorders can adversely impact a patient’s quality of life and cause socioeconomic loss. Thus, an accurate diagnosis and appropriate treatment is crucial. However, until now, diagnoses and treatments were conducted according to clinical symptoms. Objective and biological validation is lacking. This may result in a poor outcome for patients with depressive disorder. Research has been conducted to identify the biomarkers that are related to depressive disorder. Cumulative evidence has revealed that certain immunologic biomarkers including brain-derived neurotrophic factor (BDNF) and cytokines, gastrointestinal biomarkers, hormones, oxidative stress, and certain hypothalamus-pituitary axis biomarkers are associated with depressive disorder. This article reviews the biomarkers related to the diagnosis and treatment of pediatric depressive disorders. To date, clinical biomarker tests are not yet available for diagnosis or for the prediction of treatment prognosis. However, cytokines such as Interleukin-2, interferon-gamma, tumor necrosis factor-alpha, and BDNF have shown significant results in previous studies of pediatric depressive disorder. These biomarkers have the potential to be used for diagnosis, prognostic assessment, and group screening for those at high risk.

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<p>Protective Effects of <em>Spirulina platensis</em>, Voluntary Exercise and Environmental Interventions Against Adolescent Stress-Induced Anxiety and Depressive-Like Symptoms, Oxidative Stress and Alterations of BDNF and 5HT-3 Receptors of the Prefrontal Cortex in Female Rats</p>

Cited by 17 publications

References 97 publications

The effects of oral supplementation of Japanese sake yeast on anxiety, depressive-like symptoms, oxidative stress, and BDNF changes in chronically stressed adolescent rats

The effects of oral supplementation of Japanese sake yeast on anxiety, depressive-like symptoms, oxidative stress, and BDNF changes in chronically stressed adolescent rats

Prophylactic administration of rosmarinic acid ameliorates depression‐associated cardiac abnormalities in Wistar rats: Evidence of serotonergic, oxidative, and inflammatory pathways

Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review

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