&lt;p&gt;Protective Effect of Benzoquinone Isolated from the Roots of &lt;em&gt;Averrhoa carambola&lt;/em&gt; L. on Streptozotocin-Induced Diabetic Mice by Inhibiting the TLR4/NF-κB Signaling Pathway&lt;/p&gt;

Qin, Luhui; Zhang, Xiaolin; Zhou, Xing; Wu, Xingchun; Huang, Xiang; Wu, Yani; Lu, Sisi; Zhang, Hongliang; Xu, Xiaogang; Wei, Xiaojie; Zhang, Shijun; Huang, Renbin

doi:10.2147/dmso.s241998

Cited by 6 publications

(8 citation statements)

References 26 publications

(22 reference statements)

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“…The hypoglycemic activity of benzoquinone isolated from the roots of A carambola on streptozotocininduced diabetic mice was evalualed. After 21 days of treatment, a dose of 120 mg/kg of benzoquinone showed the same therapeutic effect as metformin (300 mg/kg) reducing the blood glucose levels compared with the model control group (Qin et al, 2020).…”

Section: Averrhoa Carambolamentioning

confidence: 84%

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

Vargas-Arana¹,

Salgado²,

Simirgiotis³

2023

BLACPMA

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Diabetes mellitus is a metabolic disorder characterized by the presence of chronic hyper-glycemia that is accompanied, to a greater or lesser extent, by alterations in the metabolism of carbohydrates, proteins and lipids. It is the leading cause of death in developed countries. Current antidiabetic drug treatments present several adverse effects for which it has started searching for new oral hypoglycemic agents from vegetal species. This review presents the medicinal plants from the Peruvian Amazon used in the treatment of diabetes and a systematic review of their hypoglycemic properties reported in the literature in the last twenty years used in different bibliographic databases. Seventy seven medicinal plants are reported as being used for the treatment of diabetes by Amazonian indigenous people, which 46.75% of species report hypoglycemic activity, evidencing that traditional knowledge is a great source for to searching antidiabetic drugs and also an alternative for future research.

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Section: Averrhoa Carambolamentioning

confidence: 84%

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

Vargas-Arana¹,

Salgado²,

Simirgiotis³

2023

BLACPMA

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“…Interestingly, in contrast to DC group, there were no statistical differences of serum HDL-c levels in NC, MET, SVP-L, and SVP-H groups, which is consistent with a previous study ( 34 ). In short, it was indicated that SVP could prevent T2DM-induced hyperlipidemia, thereby reducing the risk of diabetic complications ( 35 ).…”

Section: Resultsmentioning

confidence: 99%

Sanghuangporus vaninii fruit body polysaccharide alleviates hyperglycemia and hyperlipidemia via modulating intestinal microflora in type 2 diabetic mice

Huang

Chen

et al. 2022

Front. Nutr.

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The disease of type 2 diabetes mellitus (T2DM) is principally induced by insufficient insulin secretion and insulin resistance. In the current study, Sanghuangporus vaninii fruit body polysaccharide (SVP) was prepared and structurally characterized. It was shown that the yield of SVP was 1.91%, and SVP mainly contains small molecular weight polysaccharides. Afterward, the hypoglycemic and hypolipidemic effects and the potential mechanism of SVP in T2DM mice were investigated. The results exhibited oral SVP could reverse the body weight loss, high levels of blood glucose, insulin resistance, hyperlipidemia, and inflammation in T2DM mice. Oral SVP increased fecal short-chain fatty acids (SCFAs) concentrations of T2DM mice. Additionally, 16S rRNA sequencing analysis illustrated that SVP can modulate the structure and function of intestinal microflora in T2DM mice, indicating as decreasing the levels of Firmicutes/Bacteroidetes, Flavonifractor, Odoribacter, and increasing the levels of Weissella, Alloprevotella, and Dubosiella. Additionally, the levels of predicted metabolic functions of Citrate cycle, GABAergic synapse, Insulin signaling pathway were increased, and those of Purine metabolism, Taurine and hypotaurine metabolism, and Starch and sucrose metabolism were decreased in intestinal microflora after SVP treatment. These findings demonstrate that SVP could potentially play hypoglycemic and hypolipidemic effects by regulating gut microflora and be a promising nutraceutical for ameliorating T2DM.

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“…There was a decline in blood glucose, serum creatinine, and blood urea nitrogen levels and an increase in the quantity and density of podocytes (Lu et al., 2019). In another study from 2020, the administration of benzoquinone isolated from the roots of Averrhoa carambola to male Kunming mice with induced diabetes found a reduction in the blood glucose levels when compared with a control group (Qin et al., 2020). Zhang et al showed that the beneficial effects of Averrhoa carambola extracts in mice with induced diabetes were probably due to inhibition of the TLR4/TGF‐β signaling pathway by active compounds like DMDD (Zhang et al., 2020).…”

Section: Results and Discussion Of Trendsmentioning

confidence: 99%

Nutritional and medicinal properties of Star fruit (Averrhoa carambola): A review

Lakmal

Yasawardene

Jayarajah

et al. 2021

Food Science & Nutrition

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Star fruit (Averrhoa carambola), a popular fruit in many parts of the world, is considered to have many beneficial nutritional and medicinal effects. However, harmful nephrotoxic and neurotoxic effects have also been described. In this review, we have discussed the reported beneficial effects of star fruit, explored the potential mechanisms for such beneficial effects, and outline factors that may affect the safe level of consumption. The beneficial effects include the following: antioxidant (mediated via L‐ascorbic acid, epicatechin, and gallic acid), hypoglycemic (mediated via high fiber levels and 2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione), hypotensive (mediated via apigenin), hypocholesterolemic (mediated via micronized fiber), anti‐inflammatory, anti‐infective, antitumor effects, and immune‐boosting effects. The presence of chronic kidney disease, gastroenteropathies, chronic pancreatitis, dehydration, consumption on an empty stomach, and higher concentration of oxalate in fruit/juice consumed predisposes to toxicity. The level of ingestion at which the beneficial effects transition to nephrotoxicity and neurotoxicity is still to be accurately ascertained. Furthermore, the relationship between the amount of star fruit ingested and the severity of toxicity is not certain and warrants further study.

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<p>Protective Effect of Benzoquinone Isolated from the Roots of <em>Averrhoa carambola</em> L. on Streptozotocin-Induced Diabetic Mice by Inhibiting the TLR4/NF-κB Signaling Pathway</p>

Cited by 6 publications

References 26 publications

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

Sanghuangporus vaninii fruit body polysaccharide alleviates hyperglycemia and hyperlipidemia via modulating intestinal microflora in type 2 diabetic mice

Nutritional and medicinal properties of Star fruit (Averrhoa carambola): A review

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