&lt;p&gt;Prognostic Value of Ki67 in Patients with Stage 1–2 Endometrial Cancer: Validation of the Cut-off Value of Ki67 as a Predictive Factor&lt;/p&gt;

Jiang, Peng; Jia, Ming; Hu, Jiyi; Huang, Zhen; Deng, Ying; Lai, Li Wen; Ding, Shanshan; Hu, Zhuoying

doi:10.2147/ott.s274420

Cited by 21 publications

(33 citation statements)

References 32 publications

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“…In another study evaluating 473 patients with stage I-III EC by Jia et al [31], a combined ratio obtained from percentages of estrogen, progesterone, Ki-67, and TP53 was reported to be a statistically significant factor for recurrence in multivariate analysis. Recently Jiang et al [32] reported that the Ki-67 index was an independent prognostic factor in stage I and II EC. Because the Ki-67 index was also a significant factor in an univariate analysis in lowrisk disease, they claimed that it could be helpful in the de- cision of performing an adjuvant treatment.…”

Section: Discussionmentioning

confidence: 99%

The Ki-67 index and neutrophile-lymphocyte ratio are prognostic factors in patients with low-risk endometrial cancer

Çubukçu¹,

Şahin²,

Atalay³

et al. 2021

EJGO

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To investigate the prognostic factors comparing clinical, histopathological, and laboratory parameters in low-risk endometrial cancer (EC). Methods: In the present single-center study, multivariate Cox regression analysis was performed on retrospective clinical and laboratory data and histopathological features obtained from the re-evaluation of 253 patients with low-risk EC. Receiver operating characteristic curves (ROC) were plotted for neutrophile-lymphocyte ratio (NLR), platelet-lymphocyte ratio, lymphocyte-monocyte ratio and Ki-67 index for recurrence. Kaplan-Meier analysis was employed for survival rates. Results: The median age was 58.5 years (32.0-75.4). Most of the patients were obese and post-menopausal. In nearly half of the patients, lymphadenectomy was performed in addition to hysterectomy and oophorectomy. The median tumor size was 30 mm (range 2-80), and the median Ki-67 index was 25 (1-90). According to the ROC curve analysis, the cut-off values for the Ki-67 index, NLR, PLR, and LMR were determined as ≥22, ≥1.98, ≥115.3, and ≤4.71, respectively. The log-rank test revealed that the patients with a Ki-67 index lower than 22% and NLR lower than 1.98 had statistically longer recurrence-free survival (RFS) (p = 0.002 for Ki-67 index and p = 0.004 for NLR). The multivariate analysis revealed that the Ki-67 index and NLR were statistically significant factors for RFS (p = 0.012 and p = 0.029, respectively). Conclusion: The present study highlights the prognostic implications of both the Ki-67 index and NLR in lowrisk EC.

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Section: Discussionmentioning

confidence: 99%

The Ki-67 index and neutrophile-lymphocyte ratio are prognostic factors in patients with low-risk endometrial cancer

Çubukçu¹,

Şahin²,

Atalay³

et al. 2021

EJGO

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“…Therefore, immunohistochemical staining is still an economical, convenient, and time-saving method in clinical practice. ER, PR, Ki-67, and p53 are closely related to the prognosis of EC patients, Studies show that [19] the best cutoff value of Ki-67 in predicting endometrial cancer recurrence is 38%. Patients with positive ER and PR had a better prognosis, while those with p53 mutation and high Ki-67 had a poorer prognosis.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Immunohistochemical Characteristics and Recurrence After Complete Remission with Fertility Preservation Treatment in Patients with Endometrial Carcinoma and Endometrial a typical Hyperplasia

Li-wei

Xiao

Wang

et al. 2021

Preprint

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Objective To investigate the relationship between immunohistochemical characteristics and recurrence after complete remission(CR) with fertility preservation treatment in patients with endometrial cancer (EC) and endometrial atypical hyperplasia (AH). Methods The clinical data and immunohistochemical results of 53 patients with EC and 68 patients with AH admitted to Peking University People's Hospital from January 2010 to January 2021 were retrospectively analyzed. Patients were divided into two groups according to whether recurrence after complete remission (CR): Group 1: recurrence after CR; Group 2: no recurrence after CR, for statistical analysis. Results (1)The expression rate of ER in Group 1 was lower than that in Group 2, (P < 0.05). The expression rate of Ki-67 in Group 1 was significantly higher than that in Group 2, (P < 0.01). The expression rates of PR, P16, P53, and PTEN were not significantly different between the two groups (P > 0.05); (2) Combination index ER/ Ki-67 row ROC curve analysis, there was a significant difference (P < 0.01), the best cut-off value was 3.55, sensitivity 0.730, specificity 1.000, Youden index 0.730. The 3-year RFS of high rate patients was 100%, and that of low rate patients was 42.3%, P＜0.01. Conclusions The expression rate of Ki-67 is of great significance in predicting the recurrence of EC after fertility preservation therapy. The best cut-off value of combination index ER/ Ki-67 (3.55) was better than a single immunohistochemical marker in predicting recurrence of EC after fertility preservation treatment.

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“… 12 For example, in breast cancer, the positive percentage of Ki67 immunohistochemistry ≥20% is defined as a high Ki67 state, which was used to evaluate the prognosis of the patient and guide the decision-making of adjuvant treatment options. 13 In endometrial cancer, Ki67 is also closely related to the prognosis of patients, especially in early stages of tumors, Ki67 is a powerful predictor that cannot be ignored, 14 but unfortunately, Ki67 still lacks an acceptable immunohistochemical positive threshold in EC. In summary, this study aimed to explore the prognostic factors associated with LNM in early-stage EC by including “apparent” early-stage EC patients, and to determine the optimal positive threshold of the immunohistochemical parameter Ki67 for predicting LNM in early-stage EC, to provide an auxiliary reference index for treatment and prognosis management of patients.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Factors Related to Lymph Node Metastasis in Early-Stage Type 1 Endometrial Cancer: Verifying the Clinical Value of Positive Threshold of the Immunohistochemical Parameter Ki67

Jiang

Yuan

2021

CMAR

Self Cite

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Objective Lymph node metastasis (LNM) is an important reference indicator for the prognosis of endometrial cancer (EC). Even in patients with early low-risk EC, many people still have LNM. The purpose of this study was to investigate the related factors influencing LNM in early-stage EC and determine the optimal positive threshold of immunohistochemical parameter Ki67 for predicting LNM, providing auxiliary reference indicators for clinical diagnosis and treatment. Methods The clinicopathological data of 651 patients with “apparent” early-stage EC who underwent standard surgical treatment were included. Univariate and multivariate logistics regression were used to analyze the correlation between each clinicopathological factor and LNM. Receiver operating characteristic curve (ROC curve) and Youden index were used to determine the optimal positive threshold of Ki67 for predicting LNM. Finally, correlation between Ki67 and various clinicopathological factors was analyzed, and the predictive value of each prognostic factor was compared. Results Multivariate analysis found that histologic grade (P=0.023), lymphatic vessel space invasion (LVSI) (P < 0.001), serological index Ca125 (P=0.002), immunohistochemical parameter Ki67 (P < 0.001), ER (P < 0.001) and P53 (P=0.001) were independent prognostic factors of LNM. ROC curve and Youden index showed that the optimal positive thresholds of Ki67 to predict LNM were 40%. Based on this, ROC curve showed that the area under the curve (AUC) of Ki67 (AUC=0.714) was larger than other single predictors, and Ki67 combined with other predictors can significantly increase the AUC value (AUC= 0.847 and 0.868, respectively). Conclusion Ki67 was an important predictor for predicting the LNM in early-stage EC and taking a positive percentage of about 40% can be used as the positive threshold of the immunohistochemical parameter Ki67. On this basis, Ki67 combined with other predictive indicators can significantly improve prediction performance and can be used for segmentally predicting LNM of early-stage EC.

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<p>Prognostic Value of Ki67 in Patients with Stage 1–2 Endometrial Cancer: Validation of the Cut-off Value of Ki67 as a Predictive Factor</p>

Cited by 21 publications

References 32 publications

The Ki-67 index and neutrophile-lymphocyte ratio are prognostic factors in patients with low-risk endometrial cancer

The Ki-67 index and neutrophile-lymphocyte ratio are prognostic factors in patients with low-risk endometrial cancer

Analysis of Immunohistochemical Characteristics and Recurrence After Complete Remission with Fertility Preservation Treatment in Patients with Endometrial Carcinoma and Endometrial a typical Hyperplasia

Analysis of Factors Related to Lymph Node Metastasis in Early-Stage Type 1 Endometrial Cancer: Verifying the Clinical Value of Positive Threshold of the Immunohistochemical Parameter Ki67

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