<p>Prognostic Role of Prothrombin Time Activity, Prothrombin Time, Albumin/Globulin Ratio, Platelets, Sex, and Fibrinogen in Predicting Recurrence-Free Survival Time of Renal Cancer</p>

Abstract

Background To help with the clinical practice of renal cancer patients, prognostic models are urgently warranted. We hunted and identified prognostic variables associated with recurrence-free survival (RFS) for renal cancer patients. Patients and Methods In this retrospective study, 187 renal cancer patients who had received curative radical/partial nephrectomy between November 2011 and January 2017 were enrolled in the current study. These patients were randomly split into the training (n = 95) and validation sets (n = 92) by the ratio of 1:1. Univariate and multivariable Cox regression analyses were used to establish the nomogram, which was then evaluated by receiver operating characteristic (ROC) and Kaplan-Meier (K-M) analyses. Results Patient characteristics and outcomes were well balanced between the training and validation sets; the median RFS values were 54.1 months and 58.9 months for the training and validation cohorts, respectively. The final nomogram included six independent prognostic variables (prothrombin time (%), prothrombin time (second), albumin/globulin ratio, platelets, sex and fibrinogen). The mean values of RFS for the low- and high-risk groups defined by a prognostic formula were 56.22 ± 18.50 months and 49.54 ± 23.57 months, respectively, in the training cohort and were 59.00 ± 19.50 months and 53.32 ± 19.95 months, respectively, in the validation cohort. The significance and stability of the model were tested by the time-dependent K-M model and ROC curves, respectively. Conclusion Our validated prognostic model incorporates variables routinely collected from renal cancer patients, identifying subsets of patients with different survival outcomes, which provides useful information for patient care and clinical trial design.

Inflammation Markers Have Important Value in Predicting Relapse in Patients with papillary thyroid carcinoma: A Long-Term Follow-Up Retrospective Study

“…Other studies have also reported the strong ability of the NLR and PLR to predict PTC recurrence, 20 in line with our findings in 764 patients with PTC. While the prognostic effect of the AGR on renal and oral cavity cancers has been reported, 21 , 22 its prognostic effect on PTC has not. Therefore, the current study is the first to report the effect of the AGR on PTC prognosis.…”

The prognostic value of sarcopenia combined with preoperative fibrinogen–albumin ratio in patients with intrahepatic cholangiocarcinoma after surgery: A multicenter, prospective study

“… 13 Besides, previous studies showed that fibrinogen has the function of predicting the prognosis of diseases, such as spontaneous cerebral hemorrhage 14 and renal cancer. 15 More and more studies have shown that high fibrinogen and low albumin are correlated with poor prognosis in cancer patients. As a new prognostic immune biomarker, the fibrinogen–albumin ratio (FAR) has more prognostic value than high fibrinogen or low serum albumin.…”

Predictors of muscle necrosis in patients with acute compartment syndrome

“…Similarly, PT represents a widely used method to investigate coagulation in clinical laboratories. Recent studies have reported its new functions in the forecast of other medical fields, such as poor clinical outcomes in COVID-19 patients [ 27 ], bleeding risk in liver cirrhosis [ 28 ], or recurrence-free survival time of renal cancer [ 29 ]. This was the first study to use PT as a potential risk factor for muscle necrosis after ACS.…”