&lt;p&gt;Primary Juvenile Sjögren’s Syndrome in a 3-Year-Old Pediatric Female Patient: Diagnostic Role of Salivary Gland Ultrasonography: Case Report&lt;/p&gt;

Aburiziza, Abdullah J.

doi:10.2147/oarrr.s248977

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…A total of 27 children (37.5%) were prescribed oral steroid treatment for JRA [ 16 , 30 , 32 ], tubulointerstitial nephritis (TIN) [ 14 , 21 , 46 , 47 ], SLE [ 16 ], aseptic meningoencephalitis [ 14 ], severe isolated pulmonary hypertension (PH) [ 39 ], dRTA [ 46 ], mesangial glomerulonephritis [ 27 ], parotitis [ 11 , 28 , 30 , 31 , 48 ] or orbital swelling [ 17 ] ( Tables 2 and 3 ).…”

Section: Resultsmentioning

confidence: 99%

Treatment strategies for Sjögren’s syndrome with childhood onset: a systematic review of the literature

et al. 2021

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Objectives Sjögren's Syndrome (SS) with childhood onset is a rare autoimmune disease characterised by heterogeneous presentation. The lack of validated classification criteria makes it challenging to diagnose. Evidence-based guidelines for treatment of juvenile SS are not available due to the rarity of disease and the paucity of research in this patient population. This systematic review aims to summarise and appraise the current literature focused on pharmacological strategies for management of SS with childhood onset. Methods PubMed and MEDLINE/Scopus databases up to December 2020 have been screened for suitable reports highlighting pharmacological treatment of SS with childhood onset using the PRISMA 2009 reporting checklist. Animal studies have been excluded. Results 43 studies (34 case reports, 8 mini case series and one pilot study) were eligible for analysis. The studies retrieved included girls in 88% (120/137) of cases and had very low confidence level. Hydroxychloroquine (HCQ) was prescribed for parotid swelling, as well as in association with methotrexate (MTX) and non-steroidal anti-inflammatory drugs (NSAIDS) in patients with arthritis and arthralgia. Corticosteroids such as long courses of oral prednisone and IV methylprednisolone were commonly prescribed for children with severe disease presentations. Rituximab was mainly indicated for MALT lymphoma, and renal and nervous system complications. Other conventional DMARDs were prescribed in selected cases with extra-glandular manifestations. Conclusion Various therapies are used for the management of juvenile SS and are prescribed based on expert clinician’s opinion. There are currently no good quality studies that allow clinical recommendations for treatment in SS with childhood onset.

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Section: Resultsmentioning

confidence: 99%

Treatment strategies for Sjögren’s syndrome with childhood onset: a systematic review of the literature

et al. 2021

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“…With every hospitalization, the opportunity to assess the patient for Sjögren's syndrome was missed, likely due to a lower index of suspicion based on age and absence of classical signs and symptoms at the time. Pediatric patients with Sjögren's syndrome have been observed to develop sicca symptoms with increasing age, which may explain why our patient endorsed infrequent intermittent pruritic dry eyes and difficulty chewing crackers during a later hospitalization [12]. Nonetheless, once obtained, autoimmune antibodies for Sjögren's syndrome demonstrated high serum ANA and anti-Ro/SSA-52 and -60, suggesting a higher suspicion for the disease, especially as SSA-52 has a prevalence rate of 63.2% in Sjögren's syndrome [13].…”

Section: Discussionmentioning

confidence: 84%

Distal Renal Tubular Acidosis in Sjögren's Syndrome: A Case Report

Louis-Jean¹,

Ching²,

Wallingford³

2020

Cureus

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“…Depending on the stage of the disease, glands can be enlarged or be of normal or reduced size. US was addressed as the most relevant diagnostic tool in SS, but also in general in sialadenitis caused by or related to the autoimmune-system, in textbooks [63,64] and multiple publications after examination of adults [67,78,[153][154][155][156][157][158][159][160][161] and children [56,61,62,[162][163][164]. In general the parenchyma has a mixed cystic or solid echo-texture with a "leopard-skin"-like or cloudy aspect.…”

Section: Sjoegren's Syndrome/diseasementioning

confidence: 99%

“…Due to its non-invasive character and because it can be applied repeatedly without any irradiation, US has proven to be a useful and effective diagnostic measure, especially in children [43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound in Inflammatory and Obstructive Salivary Gland Diseases: Own Experiences and a Review of the Literature

Koch

Sievert

Iro

et al. 2021

JCM

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Background: Ultrasound is established as a diagnostic tool in salivary glands for obstructive diseases such as sialolithiasis and tumors. Concerning inflammatory diseases and in non-sialolithiasis-caused obstruction, much fewer data are available. In recent years, technical development has allowed a better assessment of the gland parenchyma, and knowledge about intraductal pathologies has increased considerably, which has provided new insights and a new interpretation of ultrasound findings. Objectives: To provide a comprehensive review of the literature that includes our own experiences and to point out the state of the art in ultrasound in the diagnostics of inflammatory and obstructive salivary gland diseases, taking adequate techniques and recent technical developments into consideration. Data sources and study eligibility criteria: A systematic literature search was performed in Pubmed using various specific key words. Results: According to the literature results, including our own experiences, ultrasound is of value in up to >90% of cases presenting with inflammatory and/or obstructive diseases. Technical developments (e.g., elastography) and the application of modified ultrasound techniques (e.g., transoral ultrasound) have contributed to these results. Today, ultrasound is considered a first-line diagnostic tool in these diseases. However, in some inflammatory diseases, the final diagnosis can be made only after inclusion of the anamnesis, clinical symptoms, serologic blood tests, or histopathologic investigation. Conclusions: Ultrasound can be considered as a first-line diagnostic tool in obstructive and inflammatory salivary gland diseases. In obstructive diseases, it may be sufficient for diagnostics in >90% of cases. In inflammatory diseases, ultrasound is at least an excellent screening method and can be used to establish the diagnosis in cases of an early suspicion. In all diseases ultrasound can contribute to better management and can be used for monitoring during follow-up.

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<p>Primary Juvenile Sjögren’s Syndrome in a 3-Year-Old Pediatric Female Patient: Diagnostic Role of Salivary Gland Ultrasonography: Case Report</p>

Cited by 4 publications

References 27 publications

Treatment strategies for Sjögren’s syndrome with childhood onset: a systematic review of the literature

Treatment strategies for Sjögren’s syndrome with childhood onset: a systematic review of the literature

Distal Renal Tubular Acidosis in Sjögren's Syndrome: A Case Report

Ultrasound in Inflammatory and Obstructive Salivary Gland Diseases: Own Experiences and a Review of the Literature

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