&lt;p&gt;Prescribing Pattern of Antibiotics Using WHO Prescribing Indicators Among Inpatients in Ethiopia: A Need for Antibiotic Stewardship Program&lt;/p&gt;

Demoz, Gebre Teklemariam; Kasahun, Gebremicheal Gebreslassie; Hagazy, Kalay; Woldu, Minyahil Alebachew; Wahdey, Shishay; Tadesse, Degena Bahrey; Niriayo, Yirga Legesse

doi:10.2147/idr.s262104

Cited by 38 publications

(66 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…83.63% of prescribed drugs were from the essential drugs list. Likewise, Gebre Teklemariam Demoz [11] et al reported that 52.3% of patients had at least one oral and/or injectable antibiotic prescribed. The average number of prescribed antibiotics per patient was 2.01 in their study.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Antibiotic Efficacy and Prescribing Pattern in Skin and Skin Structure Infections at a Tertiary Care Teaching Hospital

Fathima

Thomas

et al. 2021

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: This study was carried out to evaluate the efficacy and prescribing pattern of antibiotics in the skin and skin structure infections (SSTIs) at tertiary care teaching hospital. Methods: In this prospective observational study, an attempt was made to evaluate the efficacy and prescribing pattern of antibiotics. Subjects were selected according to the inclusion and exclusion criteria and patient case sheets were analyzed for patient demographic details, results of physical examination and laboratory parameters, and prescription pattern. Results: Cellulitis was the most common skin and skin structure infection among the subjects, followed by an ulcer. Few patients showed discomforts such as pain, swelling, and purulent discharge. Surgical procedure has been done in 76 patients. Out of 99 patients, 11 patients showed a prolonged length of stay (LOS) (≥16 d), which is an indication of the poor efficacy of antibiotics. Intravenous to oral antibiotic therapy switch was seen in 47 patients, which indicates that the patient’s condition was improved. The mean length of hospital stay was 8.79 d. The majority of patients have been discharged within 15 d. Cephalosporins were the most frequently prescribed class of antibiotics in patients with skin and soft tissue infections. Metronidazole was the most frequently used antibiotic as monotherapy followed by cefuroxime. Piperacillin+Tazobactam was the most frequently used combination antibiotic. This study finds that the antibiotic treatment was efficacious in the majority of the patients. Conclusion: This study finds that the antibiotic treatment was efficacious in the majority of the patients.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The average number of prescribed antibiotics per patient was 2.01 in their study. They have also found that the majority (97.6%) of antibiotics were prescribed by their generic name, and all prescribed antibiotics were from the National Essential Medicine List [11].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Antibiotic Efficacy and Prescribing Pattern in Skin and Skin Structure Infections at a Tertiary Care Teaching Hospital

Fathima

Thomas

et al. 2021

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

show abstract

“…Comparing the classes of various antimicrobials usage, it was observed that in government cephalosporins (40%) was highly used, followed by penicillins (19%), whereas in the case of private hospital cephalosporins (43%), was followed by aminoglycosides (12.3%). According to an Ethiopian study [3], cephalosporins were the widely used antimicrobials in hospitals followed by ampicillin. A similar pattern is followed in this study and also substantially supported by usage of cephalosporins in studies done in Malaysian [13], while some other studies [11] penicillin's were the most frequently prescribed drug followed by macrolides.…”

Section: Prescribing Pattern Of Antimicrobialsmentioning

confidence: 99%

“…Therefore, antimicrobials require more prudent prescribing, dispensing, and administration [2]. Irrational use of antimicrobials will result in various health hazards [3], such as drug resistance, the increased incidence of side effects, reduced effectiveness of the drug therapy, increased cost of therapy, prolonged hospital stays, and increased morbidity and mortality [4]. WHO expertise provides various methodologies and set of indicators to access drug therapy across the world.…”

Section: Introductionmentioning

confidence: 99%

Assessment of antimicrobial use in private and government hospitals, a comparative study in central kerala, using who indicators

Roy¹,

George²,

Issac³

et al. 2021

Int J Indig Herb Drug

View full text Add to dashboard Cite

Background: Irrational use of antimicrobial can cause various unwanted and untoward events. It may diminish the quality of patient care, increase the cost of therapy, and involvement in various side effects. Thus, the appropriateness of antimicrobial use in hospitals plays a pivotal role in patient safety. Objective: To analyze and assess the prescribing pattern of antimicrobials in private and government hospitals as per the WHO indicators. Methodology: A prospective comparative observational study was carried out for 6 months, with the patient diagnosed with an infectious disease admitted to the medical ward of both the hospitals during the study period. The data obtained from the study sites were Compared and analyzed using WHO indicators described in WHO’s “How to Investigate Antimicrobial use in Hospitals: Selected Indicators, Feb 2012”. Results: The study involved 216 patients and the average number of antimicrobials prescribed was found to be 1.73 in a private hospital and 2.07 in the government hospital, average cost of antimicrobials was found to be 86.48 INR in private and 31.04 INR in the government hospital, average duration of antimicrobial treatment was 4.8 in private and 5.2 in the government hospital, and the percentage of antimicrobials prescribed in generic was 33.33% in private and 87.83% in the government hospital. Considering the spectrum of antibiotics, both private (94.7%) and government (88.8%) used broad-spectrum antimicrobials. In both hospitals, cephalosporins were the most frequently prescribed class of antimicrobials. Comparing the dosage of antimicrobials given, injection usage is at the highest in government (59.5%) as well as in the private hospital (68.4%). Conclusion: This study indicates that the average cost of antimicrobials was more in a private hospital than that in a government hospital and other indicators such as the number of antimicrobials per hospitalization, duration of antimicrobial treatment, and the percentage of generic antimicrobials prescribed were all found to be more in a government hospital. In both private and government hospitals broad-spectrum antimicrobials were widely used, with cephalosporin as the most prescribed class.

show abstract

“…Due to its cost-effective and safety profile, ceftriaxone is one of the most widely used antibiotics in sub-Saharan Africa (SSA) 13 , 14 to treat different types of infections including lung infections, central nervous system infections, bone infections, abdominal infections, skin and soft tissue infections, and urinary tract infections. However, a higher rate of inappropriate use was reported in different studies.…”

Section: Introductionmentioning

confidence: 99%

Appropriate Use of Ceftriaxone in Sub-Saharan Africa: A Systematic Review

Bishaw

Tegegne

Berha

2021

IDR

View full text Add to dashboard Cite

Introduction Ceftriaxone is the most frequently used antibiotic for the treatment of various bacterial infections in hospitalized and ambulatory patients. Despite this, inappropriate ceftriaxone use is common. Objective The aim of this review is to assess the appropriate use of ceftriaxone in sub-Saharan African countries. Methods A systematic search was done on PubMed, EMBASE, Cochrane Libraries and Google Scholar for papers published addressing the prescribing pattern and use of ceftriaxone in sub-Saharan Africa. The findings were reported in medians and quartiles. Results A total of 15 articles met the inclusion criteria. Pneumonia and sepsis were the most frequently diagnosed infections in the included studies. The overall median prevalence of appropriate ceftriaxone use is 39.2% (IQR: 29.9–60.9), showing that most of the included studies reported a higher prevalence of inappropriate ceftriaxone use. Although there are a higher number of patients with inappropriate use of ceftriaxone, a relatively higher number of patients got appropriate daily dose (79.8%, IQR: 45.7–89.4) of ceftriaxone than appropriate duration of ceftriaxone (55%, IQR: 52.2–80). Conclusion The review revealed that three in five patients with ceftriaxone got inappropriate ceftriaxone’s dose, frequency or duration. A relatively higher number of patients got appropriate daily dose of ceftriaxone. On the other hand, approximately more than half of the patients got inappropriate duration, too short or too long, of ceftriaxone. Hence, prescribers are recommended to adhere to their country-specific treatment guideline. Moreover, it is highly recommended to either commence or strengthen antimicrobial stewardship program effectively in their healthcare settings.

show abstract

<p>Prescribing Pattern of Antibiotics Using WHO Prescribing Indicators Among Inpatients in Ethiopia: A Need for Antibiotic Stewardship Program</p>

Cited by 38 publications

References 46 publications

Evaluation of Antibiotic Efficacy and Prescribing Pattern in Skin and Skin Structure Infections at a Tertiary Care Teaching Hospital

Evaluation of Antibiotic Efficacy and Prescribing Pattern in Skin and Skin Structure Infections at a Tertiary Care Teaching Hospital

Assessment of antimicrobial use in private and government hospitals, a comparative study in central kerala, using who indicators

Appropriate Use of Ceftriaxone in Sub-Saharan Africa: A Systematic Review

Contact Info

Product

Resources

About