&lt;p&gt;Polydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone Tumors&lt;/p&gt;

Zhang, Meng Meng; Zhang, Fuqiang; Liu, Te; Shao, Pu; Duan, Lian; Yan, Jun; Mu, Xiaoqian; Jiang, Jinlan

doi:10.2147/ijn.s282931

Cited by 46 publications

(25 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, a promising strategy to construct biomimetic systems which utilize a unique top-down, naturally derived biomembrane coating method to functionalize nanoparticles has attracted increasing attention. [29][30][31] Natural red blood cells (RBCs) have shown good biocompatibility and low immunogenicity, resulting in long circulation time in blood stream, which make them as potential drug delivery systems for cancer and other diseases treatment. [32][33][34][35][36] This has inspired RBCs mem-brane-camouflaged nanomaterials to be utilized as promising method for the construction of biomimetic nano-drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Red‐Blood‐Cell‐Membrane‐Coated Metal‐Drug Nanoparticles for Enhanced Chemotherapy

Liang

Wang

2021

ChemBioChem

View full text Add to dashboard Cite

To overcome high toxicity, low bioavailability and poor water solubility of chemotherapeutics, a variety of drug carriers have been designed. However, most carriers are severely limited by low drug loading capacity and adverse side effects. Here, a new type of metal-drug nanoparticles (MDNs) was designed and synthesized. The MDNs self-assembled with Fe(III) ions and drug molecules through coordination, resulting in nanoparticles with high drug loading. To assist systemic delivery and prolong circulation time, the obtained MDNs were camouflaged with red blood cell (RBCs) membranes

show abstract

Section: Introductionmentioning

confidence: 99%

Red‐Blood‐Cell‐Membrane‐Coated Metal‐Drug Nanoparticles for Enhanced Chemotherapy

Liang

Wang

2021

ChemBioChem

View full text Add to dashboard Cite

show abstract

“…In addition, the hydrogel could also promote adhesion, proliferation, and ostegenic differentiation of MSCs in vitro, and enhance bone regeneration in vivo [ 332 ]. MSCs can be used as a Drug Delivery system to target on tumor cells because of the hypo-immunogenicity and migration capacity; however, MSCs may promote the progression and metastasis of tumor cells [ 333 , 334 ]. Therefore, stem cell membrane which also has bone-targeting ability and is safer than MSC, was chosen to be the delivery system for PDA nanoparticles to treat bone cancer.…”

Section: Application Of Ptt In Bone Cancermentioning

confidence: 99%

“…Stem cell membrane-camouflaged PDA nanoparticles loading with SN38 exhibited lower nonspecific macrophage uptake, longer retention in blood, and more effective accumulation in tumors than that shown by nanoparticles without stem cell membrane. These obtained nanoparticles showed synergistic anti-tumor effects of PTT and chemotherapy on MG63 cells [ 334 ]. Recently, Yao et al prepared 3D-printed scaffolds based on hydroxyapatite, PDA, and carboxymethyl CS for bone cancer therapy.…”

Section: Application Of Ptt In Bone Cancermentioning

confidence: 99%

Progress of Phototherapy Applications in the Treatment of Bone Cancer

Sun

Xing

Braun

et al. 2021

IJMS

View full text Add to dashboard Cite

Bone cancer including primary bone cancer and metastatic bone cancer, remains a challenge claiming millions of lives and affecting the life quality of survivors. Conventional treatments of bone cancer include wide surgical resection, radiotherapy, and chemotherapy. However, some bone cancer cells may remain or recur in the local area after resection, some are highly resistant to chemotherapy, and some are insensitive to radiotherapy. Phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT), is a clinically approved, minimally invasive, and highly selective treatment, and has been widely reported for cancer therapy. Under the irradiation of light of a specific wavelength, the photosensitizer (PS) in PDT can cause the increase of intracellular ROS and the photothermal agent (PTA) in PTT can induce photothermal conversion, leading to the tumoricidal effects. In this review, the progress of PT applications in the treatment of bone cancer has been outlined and summarized, and some envisioned challenges and future perspectives have been mentioned. This review provides the current state of the art regarding PDT and PTT in bone cancer and inspiration for future studies on PT.

show abstract

“…Firstly, targeting accumulation was established to enhance PTA after rational design. Typically, Zhang et al constructed PDA nanoparticles bearing the hydrophobic anticancer drug 7‐ethyl‐10‐hydroxycamptothecin (SN38) with stem cell membranes (SCM) camouflaged on their surface (M. Zhang, Zhang, et al, 2020). This specific design realized on‐demand SN38 release in response to NIR radiation and acidic stimulation, SCM‐mediated targeting accumulation, SCM as autologous antigens for activating immune responses.…”

Section: Nanobiotechnology‐assisted Thermal Ablationmentioning

confidence: 99%

Nanobiotechnology‐enabled energy utilization elevation for augmenting minimally‐invasive and noninvasive oncology thermal ablation

Zhang

Guo

Kong

et al. 2021

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Depending on the local or targeted treatment, independence on tumor type and minimally‐invasive and noninvasive feature, various thermal ablation technologies have been established, but they still suffer from the intractable paradox between safety and efficacy. It has been extensively accepted that improving energy utilization efficiency is the primary means of decreasing thermal ablation power and shortening ablation time, which is beneficial for concurrently improving both treatment safety and treatment efficiency. Recent efforts have been made to receive a significant advance in various thermal methods including non‐invasive high‐intensity focused ultrasound, minimally‐invasive radiofrequency and microwave, and non‐invasive and minimally‐invasive photothermal ablation, and so on. Especially, various nanobiotechnologies and design methodologies were employed to elevate the energy utilization efficiency for acquiring unexpected ablation outcomes accompanied with tremendously reduced power and time. More significantly, some combined technologies, for example, chemotherapy, photodynamic therapy (PDT), gaseous therapy, sonodynamic therapy (SDT), immunotherapy, chemodynamic therapy (CDT), or catalytic nanomedicine, were used to assist these ablation means to repress or completely remove tumors. We discussed and summarized the ablation principles and energy transformation pathways of the four ablation means, and reviewed and commented the progress in this field including newly developed technology or new material types with a highlight on nanobiotechnology‐inspired design principles, and provided the deep insights into the existing problems and development direction. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies

show abstract

<p>Polydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone Tumors</p>

Cited by 46 publications

References 50 publications

Red‐Blood‐Cell‐Membrane‐Coated Metal‐Drug Nanoparticles for Enhanced Chemotherapy

Red‐Blood‐Cell‐Membrane‐Coated Metal‐Drug Nanoparticles for Enhanced Chemotherapy

Progress of Phototherapy Applications in the Treatment of Bone Cancer

Nanobiotechnology‐enabled energy utilization elevation for augmenting minimally‐invasive and noninvasive oncology thermal ablation

Contact Info

Product

Resources

About