<p>Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization</p>

Abstract

In this study, we fabricated multifunctional, electrically conductive composites by incorporating graphene oxide (GO) into a poly (lactic-co-glycolic acid) (PLGA) copolymer for wound repair. Furthermore, the resultant composites were coupled with electrical stimulation to further improve the therapeutic effect of wound repair. Methods: We evaluated the surface morphology of the composites, as well as their physical properties, cytotoxicity, and antibacterial activity, along with the combined effects of composites and electrical stimulation (ES) in a rat model of wound healing. Results: Application of the PLGA/GO composites to full-thickness wounds confirmed their advantageous biological properties, as evident from the observed improvements in woundspecific mechanical properties, biocompatibility, and antibacterial activity. Additionally, we found that the combination of composites and ES improved composite-mediated cell survival and accelerated wound healing in vivo by promoting neovascularization and the formation of type I collagen. Conclusion: These results demonstrated that combined treatment with the PLGA/GO composite and ES promoted vascularization and epidermal remodeling and accelerated wound healing in rats, thereby suggesting the efficacy of PLGA/GO+ES for broad applications associated with wound repair.

Mussel-Inspired Gold Nanoparticle and PLGA/L-Lysine-g-Graphene Oxide Composite Scaffolds for Bone Defect Repair

“…In our previous study, PLGA material was demonstrated to have no obvious antibacterial activity, thus, PLGA was used as the experimental control group. 49 As shown in Figure 6A , the PDA@PLGA group showed a similar OD value as the PLGA group, indicating that the PDA coating had no obvious effect on the antibacterial properties of the material. After loading AuNPs on the surface of the PLGA scaffolds, the OD value of bacterial solutions decreased to a certain extent, but the decreasing trend was not obvious, and a significant difference was found only when scaffold was co-culture with E coli (P < 0.05).…”

Conductive Materials for Healing Wounds: Their Incorporation in Electroactive Wound Dressings, Characterization, and Perspectives

“…[ 111 ] Under external ES, the scaffold dressing exhibits high bioactivity, supporting myoblast adhesion and strengthening cell responses, further enhancing wound healing ( Table 5 ). [ 110,112–123 ] Another series of conductive hydrogels that are based on dopamine‐grafted hyaluronic acid and polydopamine‐coated reduced graphene oxide (rGO), which are crosslinked by oxidative coupling of catechol groups using an H 2 O 2 /horseradish peroxidase catalytic system, have been prepared as materials for dressing wounds (Figure 6b). [ 115 ] The as‐prepared composite hydrogels have adhesive, hemostatic, and antioxidant properties as well as mechanical properties that are similar to those of human skin.…”

Electrical aspects of skin as a pathway to engineering skin devices

“…There are many more studies on functional wound dressings. Considering in vivo studies after 2019, electrically conductive dressings containing graphene oxide (GO), 244 polypyrrole, 245,246 MXene, 247 and liquid metal integrated with a microneedle patch 248 succeeded in accelerating wound healing with external electrical stimulation. In addition, the application of conductive dressings carrying GO, 249–252 carbon nanotubes, 253,254 polypyrrole, 255 and polyaniline 256 to the skin has been reported to enhance wound healing in vivo in the absence of external stimulation, such as application of heat or antibiotics.…”