<p>Physical Activity and Thrombophilic Risk in a Short Series</p>

Abstract

The role of influence on protein C anticoagulant system and PC deficiency-related thrombophilic risk due to strenuous physical exercise is still under discussion. To investigate the modification of the protein C anticoagulant pathway after vigorous exercise, we measured ProC ® Global assay, a protein C activity dependent clotting time, in 20 healthy subjects before and immediately after maximal treadmill exercise, and at 5, 15, 30 and 60 min in the recovery phase. The most evident change was a shortening of ProC ® Global clotting time from the average basal value of 123 sec to 84 sec at 30 min in post-exercise. Our study shows that the coagulation unbalance observed after strenuous exercise and with no consequence in healthy individuals with normal PC level, could increase the thrombophilic risk in silent carriers of significant defects of the protein C system and occasionally trigger an episode of deep vein thrombosis.

Multidisciplinary In-Depth Investigation in a Young Athlete Suffering from Syncope Caused by Myocardial Bridge

“…The use of biochemical, haematological and genetic evaluation to assess risk factors in people who play sports is of growing interest at an amateur, competitive and elite level [1,3,6,46,47]. In this case report, we evaluated changes in biochemical, haematological and instrumental cardiovascular parameters and performed in-depth genetic analyses in order to shed light on the cause of repeated syncopes in an athlete who appeared to be in apparent good health but suffered from a few episodes of syncope.…”

“…Laboratory medicine and medical genetics have become disciplines necessary for monitoring athletes' health [1][2][3]. It is known that intense physical activity can cause cardiovascular disorders [4,5], thrombotic events [6,7], muscle damage [4,8,9] and infections [10][11][12][13], mostly in predisposed subjects. Consequently, the observation of the health status of competitive athletes is necessary for evaluating the stress induced by intense physical activity.…”

Exercise, Immune System, Nutrition, Respiratory and Cardiovascular Diseases during COVID-19: A Complex Combination

“…In fact, these patients are in a procoagulant state due to an increased level of tissue factor and fibrinogen influenced by impaired fibrinolysis [74]. For these reasons, athletes are not risk-free for thrombotic complications in COVID-19 infection, having an increased basic thrombophilic risk [79].…”

“…To these specific acquired conditions induced by the exercise per se, we should add that there always known or unknown personal trend to thrombosis in each subject [79]; everyone, in fact, may be an asymptomatic carrier of prothrombotic conditions as inherited or acquired thrombophilia and in addition, may take pharmacological treatments at risk for thrombotic events as oral contraceptive use [87].…”