&lt;p&gt;pH-Responsive Artesunate Polymer Prodrugs with Enhanced Ablation Effect on Rodent Xenograft Colon Cancer [Corrigendum]&lt;/p&gt;

Hao, Dan-Li; Xie, Ran; De, Gejing; Hong, Yi; Zang, Chen; Yang, Miyi; Liu, Li; Hai, Ma; Cai, Wei; Zhao, Qinghe; Sui, Feng; Chen, Yan-Jun

doi:10.2147/ijn.s260275

Cited by 2 publications

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“…The ligation reaction was stopped by adding water (10 mL), and the crude products were filtered and dried in a rotary steamer and purified via silica gel flash column chromatography (EA/PE = 2:1) to yield the desired compound. PSSP was synthesized based on our previous work [ 21 , 29 , 30 ]. Detailed synthetic routes are described in the supporting information section (Additional file 1 : Schemes S1, S2).…”

Section: Methodsmentioning

confidence: 99%

“…Artesunate (ART) is a naturally occurring sesquiterpene lactone extracted from the traditional Chinese medicine artemisia annua [ 7 – 9 ], which has been demonstrated to be effective against malaria [ 10 – 12 ]. Recent studies have found that ART also exhibits extensive antitumor effects in liver cancer [ 13 – 15 ], oral tongue squamous cell carcinoma [ 16 ], bladder cancer [ 17 , 18 ], and breast cancer [ 19 – 21 ]. However, challenges, such as poor solubility, high toxicity, and off-target accumulation, have limited its clinical use as a free ART in monotherapy [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have found that ART also exhibits extensive antitumor effects in liver cancer [ 13 – 15 ], oral tongue squamous cell carcinoma [ 16 ], bladder cancer [ 17 , 18 ], and breast cancer [ 19 – 21 ]. However, challenges, such as poor solubility, high toxicity, and off-target accumulation, have limited its clinical use as a free ART in monotherapy [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…Isosorbide 5-mononitrate (ISMN) is an NO donor mainly used in the treatment of angina pectoris [ 24 – 26 ], which has attracted the attention of many researchers due to its potential application in the field of cancer therapy [ 27 , 28 ]. The NO released by ISMN can react with reactive oxygen species (ROS) to produce a highly toxic RNS, which has been considered a far-sighted strategy for cancer treatment [ 21 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Synergetic delivery of artesunate and isosorbide 5-mononitrate with reduction-sensitive polymer nanoparticles for ovarian cancer chemotherapy

Ling

et al. 2022

J Nanobiotechnol

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Ovarian cancer is a highly fatal gynecologic malignancy worldwide. Chemotherapy remains the primary modality both for primary and maintenance treatments of ovarian cancer. However, the progress in developing chemotherapeutic agents for ovarian cancer has been slow in the past 20 years. Thus, new and effective chemotherapeutic drugs are urgently needed for ovarian cancer treatment. A reduction-responsive synergetic delivery strategy (PSSP@ART-ISMN) with co-delivery of artesunate and isosorbide 5-mononitrate was investigated in this research study. PSSP@ART-ISMN had various effects on tumor cells, such as (i) inducing the production of reactive oxygen species (ROS), which contributes to mitochondrial damage; (ii) providing nitric oxide and ROS for the tumor cells, which further react to generate highly toxic reactive nitrogen species (RNS) and cause DNA damage; and (iii) arresting cell cycle at the G0/G1 phase and inducing apoptosis. PSSP@ART-ISMN also demonstrated excellent antitumor activity with good biocompatibility in vivo. Taken together, the results of this work provide a potential delivery strategy for chemotherapy in ovarian cancer. Graphical Abstract

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synergetic delivery of artesunate and isosorbide 5-mononitrate with reduction-sensitive polymer nanoparticles for ovarian cancer chemotherapy

Ling

et al. 2022

J Nanobiotechnol

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“…Anticancer drugs from natural sources have attracted a great deal of attention worldwide (Wang & Yuan, 2013 ; Li & Leung, 2014 ; Xia et al., 2017 ; Liu et al., 2019 ; Wang et al., 2019 ; Hao et al., 2020 ; Luo et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Arenobufagin-loaded PEG-PLA nanoparticles for reducing toxicity and enhancing cancer therapy

et al. 2023

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Arenobufagin (ArBu) is a natural anticancer drug with good anti-tumor effects, but its clinical applications and drug development potential are limited due to its toxicity. The purpose of this study is to reduce the toxic side effects of ArBu and improve the efficacy of tumor treatment by incorporating it into poly(ethylene glycol)-b-poly (lactide) co-polymer (PEG-PLA). ArBu@PEG-PLA micelles were prepared by a thin film hydration method. The optimized micelles were characterized by size, stability, drug loading, encapsulation rate, and drug release. The tumor-inhibition efficacy of the micelles was evaluated on A549 cells and tumor-bearing mice. The ArBu@PEG-PLA micelles have good drug-loading capacity, release performance, and stability. They can accumulate at the tumor site through the EPR effect. The micelles induce apoptosis through a mitochondrial apoptosis pathway. Compared with the free ArBu, the ArBu@PEG-PLA micelles had lower toxicity and higher safety in the acute toxicity evaluation experiment. The in vivo anti-tumor experiment with tumor-bearing mice showed that the tumor-inhibition rate of ArBu@PEG-PLA micelles was 72.9%, which was 1.28-fold higher than that of free ArBu (57.1%), thus showing a good tumor treatment effect. This study indicates that ArBu@PEG-PLA polymeric micelles can significantly improve the toxicity and therapeutic efficacy of ArBu. These can lead to a new therapeutic strategy to reduce the toxicity of ArBu and enhance tumor treatment.

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<p>pH-Responsive Artesunate Polymer Prodrugs with Enhanced Ablation Effect on Rodent Xenograft Colon Cancer [Corrigendum]</p>

Cited by 2 publications

References 0 publications

Synergetic delivery of artesunate and isosorbide 5-mononitrate with reduction-sensitive polymer nanoparticles for ovarian cancer chemotherapy

Synergetic delivery of artesunate and isosorbide 5-mononitrate with reduction-sensitive polymer nanoparticles for ovarian cancer chemotherapy

Arenobufagin-loaded PEG-PLA nanoparticles for reducing toxicity and enhancing cancer therapy

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