&lt;p&gt;Parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography&lt;/p&gt;

Onishi, Alex C.; Treister, Alison D.; Nesper, Peter L.; Fawzi, Amani A.; Anchala, Anupama

doi:10.2147/opth.s206288

Cited by 9 publications

(8 citation statements)

References 45 publications

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“…This study results were consistent with Onishi et al (14) who analyzed parafoveal and peripapillary perfusion in healthy, glaucoma suspect, normal-tension glaucoma, and primary open-angle glaucoma subjects.…”

Section: Discussionsupporting

confidence: 92%

“…Onishi et al (14) reported that There were significant decreases in parafoveal superficial vessel density in primary open-angle (40.06±4.54%, P<0.001) and normal-tension glaucoma (42.82±5.16%, P=0.010) but not suspect eyes (45.72±4.37%, P=0.916) compared to healthy eyes (48.10±2.82%). Similarly, decreases were observed in parafoveal inner retinal thickness in primary open-angle (83.19±14.29 μm, P<0.001) and normal-tension glaucoma eyes (94.97±12.44 μm, P=0.035), but not suspect eyes (99.93±9.00 μm, P=0.648), compared to healthy controls (107.00±9.55 μm).…”

Section: Discussionmentioning

confidence: 98%

“…This table shows that IOP was distributed as14.70±1.89 and 15.45±2.16 respectively with no significant difference 2022 between groups (Table 2). This table shows NFL thickness distribution between glaucomatous and normal eyes as (NFL sup 96.05±14.42 in glaucomatous, 123.65±2.20 in normal), (NFL inf 89.95±6.97 in glaucomatous, 120.85±3.55 in normal), (NFL nasal 77.75±9.20 in glaucomatous, 86.55±4.68 in normal) and (NFL temp 75.10±8.35 in glaucomatous, 87.45±4.11 in normal), so this proves that Glaucomatous eyes group was significantly lower regard NFL (…”

mentioning

confidence: 88%

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Macular Area Perfusion in Normal and Glaucomatous Eyes Using Optical Coherence Tomography Angiography

Radwan¹,

Selim²,

Ghonaim³

2023

The Egyptian Journal of Hospital Medicine

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Background: The most common cause of blindness worldwide is glaucoma, a condition that progresses over time and has the potential to permanently impair eyesight. The only glaucoma-related anomaly for which therapy stops the disease from progressing is an increase in intraocular pressure (IOP). Objective: The aim of the current work was to elucidate the differences of perfusion in macular area between normal and glaucomatous eyes, and determine the correlation between the macular area vessel density (VD) and glaucoma severity using optical Coherence tomography angiography (OCTA). Patients and Methods: This Cross sectional prospective analytic study included 20 participants with 20 glaucomatous eyes and 20 normal eyes, attending at

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 88%

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Macular Area Perfusion in Normal and Glaucomatous Eyes Using Optical Coherence Tomography Angiography

Radwan¹,

Selim²,

Ghonaim³

2023

The Egyptian Journal of Hospital Medicine

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“…Compared with our study, previous studies report reduced superficial macula VD in either POAG or NTG eyes. [14][15][16][17] In addition, Shoji et al 18 find that superficial macula VD led to a faster loss in POAG eyes than in healthy eyes. Chao et al 19 and Shin et al 20 report that NTG groups have lower superficial and deep VD when compared with healthy eyes.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Visual Field With Peripapillary Vessel Density Through Optical Coherence Tomography Angiography in Normal-Tension Glaucoma

Lin

Huang

Yeung

et al. 2020

Trans. Vis. Sci. Tech.

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Purpose To investigate the retinal vessel density (VD) in healthy and normal-tension glaucoma (NTG) eyes through optical coherence tomography angiography (OCTA) and to determine the correlation between VD and the retinal nerve fiber layer (RNFL) thickness and functional visual field (VF) defects for different locations. Methods A total of 74 NTG eyes and 24 healthy eyes were included. OCTA VD at 4.5 × 4.5 mm peripapillary region and 3.0 × 3.0 mm macula area, RNFL thickness, and VF pattern deviation results were individually analyzed on the basis of the Garway-Heath sectorization. Correlations between VD and VF/RNFL and VF were compared. Results In the NTG group, peripapillary VD, superficial macula VD, RNFL thickness, and ganglion cell complex thickness were significantly lower. In the whole peripapillary area and inferotemporal sector, anatomic correlations between VD and VF pattern deviation values were significantly higher than those between the RNFL thickness and VF values. In the subgroup analysis, VD was anatomically correlated with VF in early-, moderate-, and severe-stage NTG eyes, whereas the RNFL thickness was correlated with VF in moderate- and severe-stage NTG eyes. Conclusions We observed VD reduction in the peripapillary retina and superficial macula area in NTG eyes. The microvascular dropout of VD in the peripapillary retina, especially in the inferotemporal sector, provided a more accurate anatomic correlation with functional VF defects than that of the RNFL thickness, especially in early-stage NTG eyes. Translational Relevance In patients who cannot comply VF exam, VD is a good tool for disease detection.

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“…Previous studies have shown repeatable and reproducible vessel density (VD) measurements by OCTA [10, 11]. Studies using OCTA in glaucomatous eyes showed decreased VD in the macular area [12]. Moreover, a significant relationship was observed between VD and the severity of glaucomatous VF damage in multiple studies [13-15].…”

Section: Introductionmentioning

confidence: 99%

Faster Macular Vessel Density Loss in More Advanced Primary Open Angle Glaucoma Eyes

et al. 2022

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Purpose: To characterize and compare the longitudinal change of macular vessel density (VD) in primary open angle glaucoma (POAG) eyes across different disease stages. Methods: This is a sub-analysis of a prospective cohort study. A total of 103 eyes (53 eyes in the mild stage, 50 eyes in the moderate-to-advanced stage) of 75 POAG patients followed for more than 1 year with at least 2 qualified optical coherence tomography (OCT) angiography (OCTA) images were included. The rates of macular VD change were determined by linear regression and compared using the generalized linear mixed models between groups. Mixed effect models were used to evaluate the demographic and ocular parameters associated with the VD loss rate. Results: With a mean follow-up time of 2.36 years, the rates of macular VD change were significantly different from zero in both groups. The rates of macular VD loss were significantly faster in moderate-to-advanced stage group than in mild stage group in whole image (-2.46%/yr vs -1.47%/yr, p=0.002), superior hemifield (-2.42%/yr vs -1.30%/yr, p=0.001), para fovea (-2.35%/yr vs -1.26, p=0.001), superior (-2.20%/yr vs -1.01%/yr, p=0.002), nasal (-2.41%/yr vs -1.04%/yr p=0.001), inferior (-2.46%/yr vs -1.43%/yr, p=0.018) and temporal sectors (-2.32%/yr vs -1.58%/yr, p=0.012). Baseline mean deviation (MD) and OCT parameters were associated with the rates of macular VD loss. Conclusions: OCTA measurements could detect vascular deterioration over time in POAG eyes at different stages. The rates of macular VD loss were significantly faster in more advanced POAG eyes.

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<p>Parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography</p>

Cited by 9 publications

References 45 publications

Macular Area Perfusion in Normal and Glaucomatous Eyes Using Optical Coherence Tomography Angiography

Macular Area Perfusion in Normal and Glaucomatous Eyes Using Optical Coherence Tomography Angiography

Correlation of Visual Field With Peripapillary Vessel Density Through Optical Coherence Tomography Angiography in Normal-Tension Glaucoma

Faster Macular Vessel Density Loss in More Advanced Primary Open Angle Glaucoma Eyes

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