&lt;p&gt;PAQR4 promotes cell proliferation and metastasis through the CDK4-pRB-E2F1 pathway in non-small-cell lung cancer&lt;/p&gt;

Wu, Bin; Liu, Rong‐Yu

doi:10.2147/ott.s181432

Cited by 20 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…al. (Wang et al, 2017;Wu and Liu, 2019;Zhang et al, 2018), we find that PAQR4 reduces cancer cell growth. Their studies suggest that PAQR4 controls cellular growth through stabilization of cyclin-dependent kinase 4 (CDK4) and hence cell cycle state.…”

Section: Discussionsupporting

confidence: 54%

Golgi-localized PAQR4 mediates Anti-apoptotic Ceramidase Activity in Breast Cancer

Pedersen

Panahandeh

Siraji

et al. 2019

Preprint

View full text Add to dashboard Cite

SummaryThe metabolic network of sphingolipids plays important roles in cancer biology. Prominent sphingolipids include ceramides and sphingosine-1-phosphate that regulate multiple aspects of growth, apoptosis and cellular signaling. Although many significant enzymatic regulators of the sphingolipid pathway have been described in detail, the list is currently incomplete. Here, we applied a systemic approach to identify and molecularly define progestin and adipoQ receptor family member IV (PAQR4) as a Golgi-localized ceramidase. We find PAQR4 to be ∼5 fold upregulated in breast cancer compared to matched control tissue and that its overexpression correlate with disease-specific survival rates in breast cancer. PAQR4 is a seven transmembrane protein, and depletion of PAQR4 leads to cellular apoptosis through accumulation of ceramides. Our findings establish PAQR4 as Golgi-localized ceramidase required for cellular growth in breast cancer.

show abstract

Section: Discussionsupporting

confidence: 54%

Golgi-localized PAQR4 mediates Anti-apoptotic Ceramidase Activity in Breast Cancer

Pedersen

Panahandeh

Siraji

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Besides, Zhang et al (2018) demonstrated that PAQR4 exert its oncogenic role in breast cancer through inhibiting CDK4 degradation. Moreover, PAQR4 promoted cell growth, metastasis, and chemoresistance in non-small-cell lung cancer ( Wu and Liu, 2019 ; Xu et al, 2020 ). Combing to our KEGG results of RNA-seq in circNOLC1 overexpression, we assumed that circNOLC1 activates PI3K/Akt pathway in PCa via a miR-647/PAQR4 axis.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA CircNOLC1, Upregulated by NF-KappaB, Promotes the Progression of Prostate Cancer via miR-647/PAQR4 Axis

Chen

Cen

Zhou

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

BackgroundCircRNAs recently have shown critical roles in tumor biology. However, their roles in prostate cancer (PCa) remains largely unclear.MethodsCircRNA microarrays were performed in immortal prostate cell line RWPE1 and PCa cell lines as DU145, PC3, LNCaP, C4-2, and 22RV1. Combined with upregulated circRNAs in PCa tissues, circNOLC1 expression was validated in PCa cells and tissues via qRT-PCR and FISH. Sanger sequencing, actinomycin D, gDNA, and cDNA, RNase R assays were used to assess the circular characteristics of circNOLC1. CCK-8, colony formation, transwell migration assays, and mice xenograft models were conducted to evaluate the functions of PCa cells after circNOLC1 knockdown and overexpression. RNA pulldown, luciferase reporter assay, FISH (fluorescence in situ hybridization), and CHIP were utilized to illustrate the further mechanisms of circNOLC1.ResultsOur research indicated that circNOLC1 was overexpressed in PCa cells and tissues, and circNOLC1 was more stable than linear NOLC1 mRNA. CircNOLC1 promoted PCa cells proliferation and migration in vitro and vivo. Additionally, we found that circNOLC1 could upregulate PAQR4 expression by sponging miR-647, leading to the activation of PI3K/Akt pathway. Moreover, NF-kappaB was identified to bind to the NOLC1 promoter sites and upregulated both NOLC1 and circNOLC1 expression.ConclusionCircNOLC1, elevated by transcription factor NF-kappaB, promotes PCa progression via a miR-647/PAQR4 axis, and circNOLC1 is a potential biomarker and target for PCa treatment.

show abstract

“…PAQR4 has a tumorigenic effect on human breast cancers, and such effect is associated with a modulatory activity of PAQR4 on protein degradation of CDK4 [40,41]. PAQR4 promotes cell proliferation and metastasis in both non-small-cell lung cancer [42] and gastric cancer [43]. C21orf58 exerts a momentous effect on breast cancer cell growth [14].…”

Section: Discussionmentioning

confidence: 99%

A novel seven-gene signature as Prognostic Biomarker in Hepatocellular Carcinoma

et al. 2020

View full text Add to dashboard Cite

Purpose: Our study is designed to develop and certify a promising prognostic signature for hepatocellular carcinoma (HCC). Materials and methods: We retrospectively analyzed mRNA expression profiles and clinicopathological data fetched from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. We formulated a prognostic seven-gene signature composed of differentially expressed mRNAs (DEmRNAs) between HCC and nonneoplastic tissues through univariate Cox regression analysis. The receiver operating characteristic (ROC) curve, survival analysis and multivariate Cox regression analysis as well as nomograms were utilized to assess the prognostic performance of the seven-gene signature. Results: The risk score based on a seven-gene signature categorized HCC subjects into a high-and low-risk group. There was significantly discrepant overall survival (OS) between patients in both groups and the corresponding ROC curve revealed a satisfactory predictive performance in HCC survival in both TCGA and GSE76427 cohort. Multivariate Cox regression analysis demonstrated that a seven-gene signature was an independently prognostic factor for HCC. Nomograms combining this prognostic signature with significant clinical characteristics conferred a crucial reference to predict the 1-,3-and 5 years OS. Conclusions: Our study defined a promising seven-gene signature and nomogram model to forecast the OS of HCC patients, which is instrumental in clinical decision and personalized therapy.

show abstract

<p>PAQR4 promotes cell proliferation and metastasis through the CDK4-pRB-E2F1 pathway in non-small-cell lung cancer</p>

Cited by 20 publications

References 23 publications

Golgi-localized PAQR4 mediates Anti-apoptotic Ceramidase Activity in Breast Cancer

Golgi-localized PAQR4 mediates Anti-apoptotic Ceramidase Activity in Breast Cancer

Circular RNA CircNOLC1, Upregulated by NF-KappaB, Promotes the Progression of Prostate Cancer via miR-647/PAQR4 Axis

A novel seven-gene signature as Prognostic Biomarker in Hepatocellular Carcinoma

Contact Info

Product

Resources

About